{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:54:20Z","timestamp":1776894860103,"version":"3.51.2"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"vor","delay-in-days":44,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003It is estimated that headache attributed to ischemic stroke occurs in 7.4% to 34% of the cases. Despite its frequency, this headache has been little studied in terms of its risk factors and characteristics.<\/jats:p><jats:p>\n          Objective\u2003To assess the frequency and clinical characteristics of headache attributed to ischemic stroke and the factors associated with its occurrence.<\/jats:p><jats:p>\n          Methods\u2003The present was a cross-sectional study which included patients consecutively admitted within 72\u2009hours of the onset of ischemic stroke. A semi-structured questionnaire was used. The patients underwent magnetic resonance imaging.<\/jats:p><jats:p>\n          Results\u2003A total of 221 patients were included, 68.2% of whom were male, and the mean age was of 68.2\u2009\u00b1\u2009\u200913.8 years. The frequency of headache attributed to ischemic stroke was of 24.9% (95% confidence interval [95%CI]: 19.6\u201331.1%). The headache had a median duration of 21\u2009hours and most frequently began at the same time as the focal deficit (45.3%), with a gradual onset (83%). It was of moderate intensity, pulsatile (45.3%), bilateral (54.6%), and presented a similar pattern to that of tension-type headache (53.6%). Headache attributed to stroke was significantly associated with previous tension-type headache, and previous migraine with and without aura (logistic regression).<\/jats:p><jats:p>\n          Conclusion\u2003Headache attributed to stroke is common, with a pattern similar to that of tension-type headache, and it is associated with a history of tension-type and migraine headaches.<\/jats:p>","DOI":"10.1055\/s-0043-1763487","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T23:57:07Z","timestamp":1681516627000},"page":"225-232","source":"Crossref","is-referenced-by-count":10,"title":["Acute headache attributed to ischemic stroke: assessment of its characteristics and associated factors"],"prefix":"10.1055","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9583-3165","authenticated-orcid":false,"given":"Felipe Ara\u00fajo Andrade de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco, \u00c1rea Acad\u00eamica de Neuropsiquiatria do Centro de Ci\u00eancias M\u00e9dicas, Recife PE, Brazil."},{"name":"Real Hospital Portugu\u00eas de Benefic\u00eancia de Pernambuco, Divis\u00e3o de Neurologia, Recife PE, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0595-8798","authenticated-orcid":false,"given":"M\u00e1rio Genu\u00edno","family":"Dourado-Filho","sequence":"additional","affiliation":[{"name":"Real Hospital Portugu\u00eas de Benefic\u00eancia de Pernambuco, Divis\u00e3o de Neurologia, Recife PE, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5725-2637","authenticated-orcid":false,"given":"Pedro Augusto Sampaio","family":"Rocha-Filho","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco, \u00c1rea Acad\u00eamica de Neuropsiquiatria do Centro de Ci\u00eancias M\u00e9dicas, Recife PE, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,4,14]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1111\/j.1526-4610.2009.01440.x","article-title":"Headache at onset of acute cerebral ischemia","volume":"49","author":"R W Evans","year":"2009","journal-title":"Headache"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/head.13478","article-title":"Headaches Attributed to Ischemic Stroke and Transient Ischemic Attack","volume":"59","author":"F AA Oliveira","year":"2019","journal-title":"Headache"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0333102417738202","article-title":"Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition","volume":"38","year":"2018","journal-title":"Cephalalgia"},{"issue":"06","key":"ref4","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1161\/01.STR.22.6.754","article-title":"Headache in transient or permanent cerebral ischemia","volume":"22","author":"P J Koudstaal","year":"1991","journal-title":"Stroke"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1161\/01.STR.15.6.1009","article-title":"Headache in cerebrovascular disease","volume":"15","author":"R K Portenoy","year":"1984","journal-title":"Stroke"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1177\/0333102414523340","article-title":"Prevalence and prognostic value of headache on early mortality in acute stroke: the Dijon Stroke Registry","volume":"34","author":"V Abadie","year":"2014","journal-title":"Cephalalgia"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1046\/j.1468-2982.2002.00357.x","article-title":"Headache as a surrogate marker of the molecular mechanisms implicated in progressing stroke","volume":"22","author":"R Leira","year":"2002","journal-title":"Cephalalgia"},{"issue":"03","key":"ref8","first-page":"156","article-title":"Prevalence of headache at the initial stage of stroke and its relation with site of vascular involvement: A clinical study","volume":"6","author":"A Ahmadi Aghangar","year":"2015","journal-title":"Caspian J Intern Med"},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1007\/s00702-013-1014-0","article-title":"Stroke in Young Fabry Patients (sifap) Investigators. 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Results from the \u201cStroke in Young Fabry Patients (SIFAP1) study\u201d","volume":"120","author":"P Kropp","year":"2013","journal-title":"J Neural Transm (Vienna)"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/ane.12621","article-title":"Headache in stroke according to National Acute Stroke Israeli Survey","volume":"135","author":"L Pollak","year":"2017","journal-title":"Acta Neurol Scand"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1046\/j.1468-2982.1994.1401037.x","article-title":"Headache in acute cerebrovascular disease: a prospective clinical study in 240 patients","volume":"14","author":"A Arboix","year":"1994","journal-title":"Cephalalgia"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1111\/j.1526-4610.2005.00267.x","article-title":"Stroke-related headache: a clinical study in lacunar infarction","volume":"45","author":"A Arboix","year":"2005","journal-title":"Headache"},{"issue":"02","key":"ref13","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/j.1468-2982.2005.01012.x","article-title":"Factors determining headache at onset of acute ischemic stroke","volume":"26","author":"P D Mitsias","year":"2006","journal-title":"Cephalalgia"},{"issue":"06","key":"ref14","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1526-4610.1995.hed3506315.x","article-title":"A multivariate study of headache associated with ischemic stroke","volume":"35","author":"J M Ferro","year":"1995","journal-title":"Headache"},{"issue":"02","key":"ref15","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1161\/01.STR.0000151360.03567.2b","article-title":"Headache at stroke onset in 2196 patients with ischemic stroke or transient ischemic attack","volume":"36","author":"S Tentschert","year":"2005","journal-title":"Stroke"},{"issue":"07","key":"ref16","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1161\/STROKEAHA.113.677070","article-title":"Onset headache predicts good outcome in patients with first-ever ischemic stroke","volume":"44","author":"P K Chen","year":"2013","journal-title":"Stroke"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1161\/01.STR.0000035286.87503.31","article-title":"Characterization of incident stroke signs and symptoms: findings from the atherosclerosis risk in communities study","volume":"33","author":"S S Rathore","year":"2002","journal-title":"Stroke"},{"issue":"04","key":"ref18","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1136\/jnnp.58.4.490","article-title":"Headache at stroke onset: the Lausanne Stroke Registry","volume":"58","author":"E Kumral","year":"1995","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"11","key":"ref19","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1161\/01.STR.24.11.1621","article-title":"Headache in stroke","volume":"24","author":"K Vestergaard","year":"1993","journal-title":"Stroke"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/brain\/awv333","article-title":"Headache in acute ischaemic stroke: a lesion mapping study","volume":"139","author":"C L Seifert","year":"2016","journal-title":"Brain"},{"issue":"04","key":"ref21","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1468-2982.2007.01514.x","article-title":"Headache in acute stroke. 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Trial of Org 10172 in Acute Stroke Treatment","volume":"24","author":"H P Adams Jr","year":"1993","journal-title":"Stroke"},{"issue":"05","key":"ref25","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/head.12563","article-title":"Post-craniotomy headache: a clinical view with a focus on the persistent form","volume":"55","author":"P AS Rocha-Filho","year":"2015","journal-title":"Headache"},{"issue":"07","key":"ref26","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1526-4610.2006.00507.x","article-title":"Clinical implications of headache in lacunar stroke: relevance of site of infarct","volume":"46","author":"A Arboix","year":"2006","journal-title":"Headache"},{"issue":"06","key":"ref27","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/ana.21390","article-title":"Co-Operative Study of Brain Injury Depolarisations (COSBID). Spreading depolarizations occur in human ischemic stroke with high incidence","volume":"63","author":"C Dohmen","year":"2008","journal-title":"Ann Neurol"},{"issue":"06","key":"ref28","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/head.14319","article-title":"Headache associated with COVID-19: Epidemiology, characteristics, pathophysiology, and management","volume":"62","author":"P A Sampaio Rocha-Filho","year":"2022","journal-title":"Headache"},{"issue":"02","key":"ref29","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/CIRCULATIONAHA.111.045096","article-title":"Migraine mutations increase stroke vulnerability by facilitating ischemic depolarizations","volume":"125","author":"K Eikermann-Haerter","year":"2012","journal-title":"Circulation"},{"issue":"04","key":"ref30","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1111\/j.1526-4610.2010.01647.x","article-title":"Cortical spreading depression triggers migraine attack: pro","volume":"50","author":"C Ayata","year":"2010","journal-title":"Headache"},{"issue":"04","key":"ref31","first-page":"823","article-title":"Tension-type headache","volume":"18","author":"R G Kaniecki","year":"2012","journal-title":"Continuum (Minneap Minn)"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1763487.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T23:57:42Z","timestamp":1681516662000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1763487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":31,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2023,4,14]]},"published-print":{"date-parts":[[2023,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1763487","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0004-282X","1678-4227"],"issn-type":[{"value":"0004-282X","type":"print"},{"value":"1678-4227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]}}}