{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:10:56Z","timestamp":1772806256416,"version":"3.50.1"},"reference-count":7,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T00:00:00Z","timestamp":1680480000000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Neurosurg"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Herein, we present a rare patient with hereditary spastic paraparesis (HSP) in whom significant parkinsonism was involved in the clinic. Besides, the dopamine transport single-photon emission computed tomography scan also showed decreased tracer uptake in the bilateral striatum. Via the presentation of this patient, we discuss the parkinsonian findings in patients with HSP. We think that the observations of dopaminergic neuron vulnerability in HSP patients raise the possibility that degeneration of central dopaminergic neurons may contribute to the phenotype of HSP. The documentation of these rare variants will aid to understand the unknown pathophysiology of the disease course.<\/jats:p>","DOI":"10.1055\/s-0043-1764117","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T23:26:55Z","timestamp":1680564415000},"page":"216-218","source":"Crossref","is-referenced-by-count":2,"title":["A Rare Patient with Hereditary Spastic Paraparesis with Parkinsonism"],"prefix":"10.1055","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1823-2278","authenticated-orcid":false,"given":"Halil","family":"Onder","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selcuk","family":"Comoglu","sequence":"additional","affiliation":[{"name":"Neurology Clinic, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/S1474-4422(19)30235-2","article-title":"Hereditary spastic paraplegia: from diagnosis to emerging therapeutic approaches","volume":"18","author":"S Shribman","year":"2019","journal-title":"Lancet Neurol"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.aanat.2008.11.003","article-title":"Widespread thalamic and cerebellar degeneration in a patient with a complicated hereditary spastic paraplegia (HSP)","volume":"191","author":"K Seidel","year":"2009","journal-title":"Ann Anat"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1002\/mds.27812","article-title":"Parkinsonism and spastic paraplegia type 7: expanding the spectrum of mitochondrial Parkinsonism","volume":"34","author":"B De la Casa-Fages","year":"2019","journal-title":"Mov Disord"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.parkreldis.2017.02.025","article-title":"Parkinsonian-pyramidal syndromes: a systematic review","volume":"39","author":"C Tranchant","year":"2017","journal-title":"Parkinsonism Relat Disord"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.3346\/jkms.2013.28.11.1661","article-title":"Striatal dopaminergic functioning in patients with sporadic and hereditary spastic paraplegias with parkinsonism","volume":"28","author":"J S Kim","year":"2013","journal-title":"J Korean Med Sci"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neurobiolaging.2006.09.004","article-title":"Loss of spastic paraplegia gene atlastin induces age-dependent death of dopaminergic neurons in Drosophila","volume":"29","author":"Y Lee","year":"2008","journal-title":"Neurobiol Aging"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"105650","DOI":"10.1016\/j.nbd.2022.105650","article-title":"Striatal synaptic dysfunction in dystonia and levodopa-induced dyskinesia","volume":"166","author":"M Scarduzio","year":"2022","journal-title":"Neurobiol Dis"}],"container-title":["Asian Journal of Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1764117.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:50:00Z","timestamp":1681260600000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1764117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":7,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2023,4,11]]},"published-print":{"date-parts":[[2023,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1764117","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1793-5482","2248-9614"],"issn-type":[{"value":"1793-5482","type":"print"},{"value":"2248-9614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]}}}