{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:58:17Z","timestamp":1781179097890,"version":"3.54.1"},"reference-count":10,"publisher":"Scientific Scholar","issue":"02","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["South Asian J Cancer"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:p>Ewing sarcoma arises in both bones (most common) and soft tissues and it commonly affects young adults. The tumor is composed of small round cells showing positivity for CD99 and FLI1 on immunohistochemistry (IHC). We describe ganglion cell differentiation post-chemotherapy in Ewing sarcoma which is a rare phenomenon.<\/jats:p>\n                  <jats:p>A 13-year-old girl presented with a chest wall mass. On biopsy correlating with IHC, the diagnosis was rendered as Ewing sarcoma. She underwent neoadjuvant chemotherapy followed by resection of the tumor. On microscopic evaluation, the tumor showed prominent ganglionic differentiation with expression of neuronal markers.<\/jats:p>\n                  <jats:p>Although maturation post-chemotherapy is an established finding with better prognosis in other primitive pediatric tumors, such neural differentiation is rare with only a few case reports in Ewing sarcoma both post- and pre-chemotherapy. Clinical significance and prognosis of such differentiation which appear to be better are not yet established and needs to be elucidated.<\/jats:p>","DOI":"10.1055\/s-0043-1764148","type":"journal-article","created":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T19:15:00Z","timestamp":1677698100000},"page":"213-216","source":"Crossref","is-referenced-by-count":0,"title":["Ewing Sarcoma with Ganglion Cells Post-Chemotherapy: A Case Report with Review of Literature"],"prefix":"10.25259","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6985-8636","authenticated-orcid":false,"given":"Karthik","family":"Dhandapani","sequence":"additional","affiliation":[{"name":"Department of Onco-pathology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3557-3389","authenticated-orcid":false,"given":"Jahnavi","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Onco-pathology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7717-295X","authenticated-orcid":false,"given":"Amisha","family":"Gami","sequence":"additional","affiliation":[{"name":"Department of Onco-pathology, Gujarat Cancer and Research Institute, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2023,3,1]]},"reference":[{"key":"ref1","first-page":"274","volume-title":"Ossifying fibromyxoid tumor","author":"M Endo","year":"2020"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-40618-3","volume-title":"Eds. AJCC Cancer Staging Manual 8th edition","author":"M B Amin","year":"2017"},{"key":"ref3","volume-title":"WHO Classification of Tumours of Endocrine Organs","author":"R Lloyd","year":"2017"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1309\/AJCPFHFX07JFCRGU","article-title":"Ewing sarcoma with extensive neural differentiation: a clinicopathologic, immunohistochemical, and molecular analysis of three cases","volume":"143","author":"A Weissferdt","year":"2015","journal-title":"Am J Clin Pathol"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1440-1827.1998.tb03936.x","article-title":"Ganglion cells in Ewing's sarcoma following chemotherapy: a case report","volume":"48","author":"G Maeda","year":"1998","journal-title":"Pathol Int"},{"issue":"02","key":"ref6","first-page":"139","article-title":"Therapy-induced neural differentiation in Ewing's sarcoma: a case report and review of the literature","volume":"35","author":"K E Erdo\u011fan","year":"2019","journal-title":"Turk Patoloji Derg"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13000-016-0516-0","article-title":"Maturation toward neuronal tissue in an Ewing sarcoma of bone after chemotherapy","volume":"11","author":"M CW Salet","year":"2016","journal-title":"Diagn Pathol"},{"issue":"08","key":"ref8","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1097\/00000478-200308000-00016","article-title":"Evidence of neural differentiation in a case of post-therapy primitive neuroectodermal tumor\/Ewing sarcoma of bone","volume":"27","author":"P Collini","year":"2003","journal-title":"Am J Surg Pathol"},{"issue":"07","key":"ref9","first-page":"483","article-title":"Primitive neuroectodermal tumors of bone and soft tissue. With reference to histologic differentiation in primary or metastatic foci","volume":"42","author":"S Ushigome","year":"1992","journal-title":"Acta Pathol Jpn"},{"issue":"04","key":"ref10","doi-asserted-by":"crossref","first-page":"e19305","DOI":"10.1371\/journal.pone.0019305","article-title":"Modeling initiation of Ewing sarcoma in human neural crest cells","volume":"6","author":"C von Levetzow","year":"2011","journal-title":"PLoS One"}],"container-title":["South Asian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1764148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:12:43Z","timestamp":1781176363000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.sajc.org\/ewing-sarcoma-with-ganglion-cells-post-chemotherapy-a-case-report-with-review-of-literature\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,1]]},"references-count":10,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2023,11,9]]},"published-print":{"date-parts":[[2023,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1764148","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2278-330X","2278-4306"],"issn-type":[{"value":"2278-330X","type":"print"},{"value":"2278-4306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,1]]}}}