{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:38:19Z","timestamp":1792028299000,"version":"4.4.0"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"03","funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["SFB1315"],"award-info":[{"award-number":["SFB1315"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["FOR3004"],"award-info":[{"award-number":["FOR3004"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Einstein Stiftung Fellowship through the G\u00fcnter Endres Fond and the Sonnenfeld-Stiftung"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003Family burden (FB) in pediatric patients with drug-resistant epilepsy (DRE) is significantly higher than that in children with non-DRE. Epilepsy surgery is an established approach to treat DRE, and this study examines the impact of pediatric epilepsy surgery on FB.<\/jats:p><jats:p>\n          Methods\u2003We retrospectively analyzed data of families and pediatric patients with focal structural DRE treated with epilepsy surgery at our epilepsy center from April 2018 to November 2021. We examined the relationship between cognitive, behavioral, and epilepsy-specific data and the FB measured with the German version of the Impact on Family Scale before and after epilepsy surgery.<\/jats:p><jats:p>\n          Results\u2003The study cohort included 31 children with DRE at a mean age of 9 years at surgery (range\u2009=\u20090\u201316) and a mean epilepsy duration of 3 years (range\u2009=\u20090\u201314). Cognitive impairment correlated with FB in children with DRE prior to surgery. At the last assessment, 14.5 months (mean, range\u2009=\u20096\u201324) after epilepsy surgery, 87.2% of patients were seizure-free, FB values had decreased by 75.0%, and behavioral problems had decreased by 85,7%. Cognitive functions remained stable following epilepsy surgery.<\/jats:p><jats:p>\n          Conclusion\u2003In children with DRE, epilepsy surgery reduces FB. Given the considerable impact of families on the development and wellbeing of their children, the impact of epilepsy surgery should be communicated to affected families.<\/jats:p>","DOI":"10.1055\/s-0043-1764215","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T23:38:26Z","timestamp":1678923506000},"page":"182-187","source":"Crossref","is-referenced-by-count":3,"title":["Family Burden and Epilepsy Surgery in Children with Drug-Resistant Epilepsy"],"prefix":"10.1055","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8617-2924","authenticated-orcid":false,"given":"Sebastian","family":"Hoyer","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Center for Chronically Sick Children, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin L.","family":"Makridis","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Center for Chronically Sick Children, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Institute of Cell Biology and Neurobiology, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz A.","family":"Atalay","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Center for Chronically Sick Children, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich-W","family":"Thomale","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurosurgery, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Prager","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Center for Chronically Sick Children, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian E.","family":"Elger","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Center for Chronically Sick Children, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Beta Neurologie - Kompetenzzentrum f\u00fcr Epilepsie, Beta Klinik GmbH, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Kaindl","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Center for Chronically Sick Children, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Berlin, Germany"},{"name":"Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Institute of Cell Biology and Neurobiology, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,3,15]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1055\/s-0037-1609034","article-title":"Cognitive development in pediatric epilepsy surgery","volume":"49","author":"G Ramantani","year":"2018","journal-title":"Neuropediatrics"},{"issue":"08","key":"ref2","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1111\/epi.16602","article-title":"Family resources moderate the relationship between seizure control and health-related quality of life in children with drug-resistant epilepsy","volume":"61","author":"N L Phillips","year":"2020","journal-title":"Epilepsia"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"107538","DOI":"10.1016\/j.yebeh.2020.107538","article-title":"The impact of severe pediatric epilepsy on experienced stress and psychopathology in parents","volume":"113","author":"A V Jakobsen","year":"2020","journal-title":"Epilepsy Behav"},{"issue":"07","key":"ref4","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s10072-019-03822-6","article-title":"Stress and perceived stigma among parents of children with epilepsy","volume":"40","author":"A Rani","year":"2019","journal-title":"Neurol Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"100917","DOI":"10.1016\/j.spen.2021.100917","article-title":"The missed value of underutilizing pediatric epilepsy surgery: a systematic review","volume":"39","author":"C W Beatty","year":"2021","journal-title":"Semin Pediatr Neurol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.yebeh.2017.07.042","article-title":"Health-related quality of life and emotional wellbeing improve in parents after their children have undergone epilepsy surgery\u2014a prospective population-based study","volume":"75","author":"C Reilly","year":"2017","journal-title":"Epilepsy Behav"},{"key":"ref7","first-page":"384","article-title":"Der familien-belastungs-fragebogen (FaBel-fragebogen)","volume":"51","author":"U Ravens-Sieberer","year":"2001","journal-title":"Psychother Psychosom Med Psychol"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1016\/j.ridd.2011.05.021","article-title":"Family impact in intellectual disability, severe mental health disorders and mental health disorders in ID. 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