{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:49:30Z","timestamp":1793785770320,"version":"4.6.1"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"07","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Thromb Hemost"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sex-specific factors are implicated in pulmonary embolism (PE) presentation in young patients, as indicated by increased risk in pregnancy. Whether sex differences exist in PE presentation, comorbidities, and symptomatology in older adults, the age group in which most PEs occur, remains unknown. We identified older adults (aged \u226565 years) with PE in a large international PE registry replete with information about relevant clinical characteristics (RIETE registry, 2001\u20132021). To provide national data from the United States, we assessed sex differences in clinical characteristics and risk factors of Medicare beneficiaries with PE (2001\u20132019). The majority of older adults with PE in RIETE (19,294\/33,462, 57.7%) and in the Medicare database (551,492\/948,823, 58.7%) were women. Compared with men, women with PE less frequently had atherosclerotic diseases, lung disease, cancer, or unprovoked PE, but more frequently had varicose veins, depression, prolonged immobility, or history of hormonal therapy (p\u2009&lt;\u20090.001 for all). Women less often presented with chest pain (37.3 vs. 40.6%) or hemoptysis (2.4 vs. 5.6%) but more often with dyspnea (84.6 vs. 80.9%) (p\u2009&lt;\u20090.001 for all). Measures of clot burden, PE risk stratification, and use of imaging modalities were comparable between women and men. PE is more common in elderly women than in men. Cancer and cardiovascular disease are more common in men, whereas transient provoking factors including trauma, immobility, or hormone therapy are more common in elderly women with PE. Whether such differences correlate with disparities in treatment or differences in short- or long-term clinical outcomes warrants further investigation.<\/jats:p>","DOI":"10.1055\/s-0043-1764231","type":"journal-article","created":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T19:13:45Z","timestamp":1677870825000},"page":"725-735","source":"Crossref","is-referenced-by-count":25,"title":["Sex-Related Differences in Patient Characteristics, Risk Factors, and Symptomatology in Older Adults with Pulmonary Embolism: Findings from the SERIOUS-PE Study"],"prefix":"10.1055","volume":"49","author":[{"given":"Behnood","family":"Bikdeli","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"},{"name":"Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"},{"name":"YNHH\/Yale Center for Outcomes Research and Evaluation (CORE), New Haven, Connecticut"},{"name":"Cardiovascular Research Foundation (CRF), New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Muriel","sequence":"additional","affiliation":[{"name":"Department of Respiratory, Hospital Ram\u00f3n y Cajal, Universidad de Alcal\u00e1 (Instituto de Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria), Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Respiratorias, Madrid, Spain"},{"name":"Clinical Biostatistics Unit, Hospital Universitario Ram\u00f3n y Cajal, IRYCIS, CIBERESP: Universidad de Alcal\u00e1, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"YNHH\/Yale Center for Outcomes Research and Evaluation (CORE), New Haven, Connecticut"},{"name":"Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Piazza","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"},{"name":"Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candrika D.","family":"Khairani","sequence":"additional","affiliation":[{"name":"Thrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel P.","family":"Rosovsky","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghazaleh","family":"Mehdipoor","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation (CRF), New York, New York"},{"name":"Division of Nuclear Medicine, Department of Radiology, Montefiore Medical Center, Bronx, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle L.","family":"O'Donoghue","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts"},{"name":"TIMI Study Group, Brigham and Women's Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Madridano","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Infanta Sof\u00eda, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Bosco","family":"Lopez-Saez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario de Puerto Real, C\u00e1diz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meritxell","family":"Mellado","sequence":"additional","affiliation":[{"name":"Department of Angiology and Vascular Surgery, Hospital del Mar, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria Diaz","family":"Brasero","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario de Guadalajara, Guadalajara, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Grandone","sequence":"additional","affiliation":[{"name":"Thrombosis and Haemostasis Unit, Fondazione I.R.C.C.S. \u201cCasa Sollievo della Sofferenza,\u201d Foggia, S. Giovanni Rotondo, Italy"},{"name":"Department of Medical and Surgical Sciences, Institute of Obstetrics and Gynecology, University of Foggia, Foggia, Italy"},{"name":"Department of Obstetrics Gynaecology and Perinatal Medicine, I.M. Sechenov First Moscow State Medical University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Primavera A.","family":"Spagnolo","sequence":"additional","affiliation":[{"name":"Mary Horrigan Connors Center for Women's Health & Gender Biology, Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Lu","sequence":"additional","affiliation":[{"name":"YNHH\/Yale Center for Outcomes Research and Evaluation (CORE), New Haven, Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Bertoletti","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Brigham and Women Hospital, Service de M\u00e9decine Vasculaire et Th\u00e9rapeutique, CHU de St-Etienne, Saint-Etienne, France"},{"name":"INSERM, UMR1059, Equipe Dysfonction Vasculaire et H\u00e9mostase, Universit\u00e9 Jean-Monnet, Saint-Etienne, France"},{"name":"INSERM, CIC-1408, CHU Saint-Etienne, Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"L\u00f3pez-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Provincial Reina Sof\u00eda, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel Jes\u00fas","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Complejo Hospitalario de Pontevedra, Pontevedra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngeles","family":"Blanco-Molina","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Reina Sof\u00eda, C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Gerhard-Herman","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard 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