{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:37:16Z","timestamp":1780105036834,"version":"3.54.0"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003In pediatric Crohn's disease ileocecal resection is performed reluctantly as postoperative recurrence is frequent. Anti-tumor necrosis factor (TNF) therapy reduces postoperative recurrence rates but increases the risk for infections.<\/jats:p><jats:p>\n          Materials and Methods\u2003We retrospectively reviewed pediatric Crohn's disease patients who underwent ileocecal resection in our center. We compared disease activity and z-scores for height, weight, and body mass index of patients, who continuously received perioperative anti-TNF therapy (TNF\u2009+\u2009), with those who did not (TNF\u2013).<\/jats:p><jats:p>\n          Results\u2003Of 29 patients (48% females), 13 and 16 were grouped to TNF+ and TNF\u2013, respectively. Patients' characteristics did not differ between groups, except a longer follow-up time in TNF\u2013. We saw significant postoperative improvement but no normalization in z-scores for weight (1.78 vs. 0.77, p\u2009&lt;\u20090.001), body mass index (1.08 vs. 0.22, p\u2009&lt;\u20090.001), and height (0.88 vs. 0.66, p\u2009&lt;\u20090.001). Disease activity improved significantly more in patients receiving anti-TNF therapy (moderate improvement in 83% vs. 31%, p\u2009=\u20090.02). Endoscopic recurrence was more frequent in patients without anti-TNF therapy (80% vs. 20%; p\u2009=\u20090.023), but endoscopic follow-up was incomplete. There was no increase of infections under perioperative anti-TNF therapy (1 patient each; p\u2009=\u20091.000).<\/jats:p><jats:p>\n          Conclusion\u2003In patients with localized Crohn's disease an ileocecal resection leads to short-term postoperative improvement of disease activity, body mass index, weight, and growth. For relevant catch-up growth an earlier intervention is necessary. Continuous perioperative anti-TNF therapy had no increased risk of perioperative infections.<\/jats:p>","DOI":"10.1055\/s-0043-1764320","type":"journal-article","created":{"date-parts":[[2023,3,17]],"date-time":"2023-03-17T00:01:17Z","timestamp":1679011277000},"page":"236-244","source":"Crossref","is-referenced-by-count":5,"title":["Children with Localized Crohn's Disease Benefit from Early Ileocecal Resection and Perioperative Anti-Tumor Necrosis Factor Therapy"],"prefix":"10.1055","volume":"34","author":[{"given":"Elena","family":"Weigl","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Schwerd","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Dr. von Hauner Children's Hospital, University Hospital Munich, LMU Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhard","family":"Lurz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Dr. von Hauner Children's Hospital, University Hospital Munich, LMU Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beate","family":"H\u00e4berle","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibylle","family":"Koletzko","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, Dr. von Hauner Children's Hospital, University Hospital Munich, LMU Munich, Bayern, Germany"},{"name":"Department of Pediatrics, Gastroenterology and Nutrition, School of Medicine Collegium Medicum University of Warmia and Mazury, Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Hubertus","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/MPG.0000000000002162","article-title":"Pediatric chronic inflammatory bowel disease in a German Statutory Health INSURANCE-incidence rates from 2009 to 2012","volume":"68","author":"R Wittig","year":"2019","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/MCG.0b013e318247c32f","article-title":"Natural history of pediatric-onset inflammatory bowel disease: a systematic review","volume":"46","author":"B P 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