{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:40:10Z","timestamp":1780486810808,"version":"3.54.1"},"reference-count":41,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"name":"NIH Grant","award":["R01 NR014245"],"award-info":[{"award-number":["R01 NR014245"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>\n            Objective\u2003The purpose of our study was to evaluate the body mass index (BMI)-specific association between early gestational weight gain (GWG) in dichorionic twin pregnancies and the risk of preeclampsia.<\/jats:p><jats:p>\n            Study Design\u2003We conducted a retrospective cohort study of all dichorionic twin pregnancies from 1998 to 2013. Data were obtained from a perinatal database and chart abstraction. Prepregnancy BMI was categorized as normal (18.5\u201324.9\u2009kg\/m2), overweight (25\u201329.9\u2009kg\/m2), and obese (\u226530\u2009kg\/m2). Early GWG was defined as the last measured weight from 160\/7 to 196\/7weeks' gestation minus prepregnancy weight. GWG was standardized for gestational duration using BMI-specific z-score charts for dichorionic pregnancies. Preeclampsia was diagnosed using American College of Obstetricians and Gynecologists criteria and identified with International Classification of Diseases-9 coding. Early GWG z-score was modeled as a three-level categorical variable (\u2264\u2009\u2212\u20091 standard deviation [SD], 0, 3 +1 SD), where \u22121 to +1 was the referent group. We estimated risk differences and 95% confidence intervals (CIs) via marginal standardization.<\/jats:p><jats:p>\n            Results\u2003We included 1,693 dichorionic twin pregnancies in the cohort. In adjusted analysis, the incidence of preeclampsia increased with increasing early GWG among women with normal BMI. Women with normal BMI and a GWG z-score\u2009&lt;\u2009\u2212\u20091 (equivalent to 2.6\u2009kg by 20 weeks) had 2.5 fewer cases of preeclampsia per 100 births (95% CI: \u22124.7 to\u2009\u2212\u20090.3) compared with the referent; those with GWG z-score\u2009&gt;\u2009+1 (equivalent to gaining 9.8\u2009kg by 20 weeks) had 2.8 more cases of preeclampsia per 100 (95 % CI: 0.1\u20135.5) compared with the referent. In adjusted analyses, early GWG had minimal impact on the risk of preeclampsia in women with overweight or obesity.<\/jats:p><jats:p>\n            Conclusion\u2003GWG of 2.6\u2009kg or less by 20 weeks was associated with a decreased risk of preeclampsia among women pregnant with dichorionic twins and normal prepregnancy BMI. Current GWG guidelines focus on optimizing fetal weight and gestational length. Our findings demonstrate the importance of considering other outcomes when making GWG recommendations for twin pregnancy.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0043-1764345","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T00:12:45Z","timestamp":1678839165000},"page":"1040-1046","source":"Crossref","is-referenced-by-count":1,"title":["Early Gestational Weight Gain and the Risk of Preeclampsia in Dichorionic Twin Pregnancies"],"prefix":"10.1055","volume":"40","author":[{"given":"Tiffany E.","family":"Deihl","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Bodnar","sequence":"additional","affiliation":[{"name":"Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara M.","family":"Parisi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine P.","family":"Himes","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"},{"name":"Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"ref1","volume-title":"Three Decades of Twin Births in the United States, 1980\u20132009","author":"J A Martin","year":"2012"},{"key":"ref2","volume-title":"Is Twin Childbearing on the Decline? 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