{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:21:56Z","timestamp":1790767316446,"version":"4.1.0"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to evaluate the prevalence of adverse outcomes, specifically pulmonary hypertension (PH) and suspected or confirmed necrotizing enterocolitis (NEC), and their associated risk factors, in neonates treated with diazoxide.<\/jats:p><jats:p>\n            Study Design\u2003A retrospective study in infants born \u2265 316\/7 weeks and admitted between January 2014 and June 2020. Combined adverse outcomes possibly associated to diazoxide were PH (systolic pulmonary pressure of \u226540\u2009mm Hg or an eccentricity index \u22651.3) and suspected or confirmed NEC (suspected: stop feeds and antibiotics and confirmed: modified Bell stage \u22652). Echocardiography data extractors were masked to infants' characteristics.<\/jats:p><jats:p>\n            Results\u2003A total of 63 infants were included; 7 (11%) with suspected and 1 (2%) with confirmed NEC. Of the 36 infants with an available echocardiography after initiation of diazoxide treatment, 12 (33%) had PH. All infants with suspected or confirmed NEC were males (p\u2009=\u20090.01), whereas PH occurred mostly in females (75%, p\u2009=\u20090.02). The combined adverse outcome occurred in 14\/26 (54%) infants exposed to &gt;10\u2009mg\/kg\/day, compared to 6\/37 (16%) exposed to \u226410\u2009mg\/kg\/day (p\u2009=\u20090.006). This association remained significant after adjustment for sex, small for gestational age status, and gestational age at birth (odds ratio: 6.1, 95% confidence interval: 1.7\u201321.7, p\u2009=\u20090.005). Left ventricular dysfunction was found in 19 infants (30%) but was not discriminative for the combined outcome.<\/jats:p><jats:p>\n            Conclusion\u2003PH and suspected or confirmed NEC were identified frequently in neonates treated with diazoxide. A total dose &gt;10\u2009mg\/kg\/day was associated with an increased occurrence of these complications.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0043-1764385","type":"journal-article","created":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T23:57:00Z","timestamp":1678233420000},"page":"e1435-e1444","source":"Crossref","is-referenced-by-count":8,"special_numbering":"S","title":["Pulmonary Hypertension and Necrotizing Enterocolitis in Neonates Treated with Diazoxide"],"prefix":"10.1055","volume":"41","author":[{"given":"Mounya","family":"Duggal","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiran S.","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Simoneau","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Girard","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ir\u00e8ne B.","family":"Gernet","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Montreal Children's Hospital, McGill University Health Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia E. 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