{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:49Z","timestamp":1782950449892,"version":"3.54.5"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Chronic low back pain (CLBP) is a global health problem, and gabapentin and pregabalin are often used in the treatment of patients without associated radiculopathy or neuropathy. Therefore, determining their efficacy and safety is of enormous value.<\/jats:p><jats:p>\n          Objective To examine the efficacy and safety of using gabapentin and pregabalin for CLBP without radiculopathy or neuropathy.<\/jats:p><jats:p>\n          Methods\u2003We performed a search on the CENTRAL, MEDLINE, EMBASE, LILACS, and Web of Science data bases for clinical trials, cohorts, and case-control studies that evaluated patients with CLBP without radiculopathy or neuropathy for at least eight weeks. The data were extracted and inserted into a previously-prepared Microsoft Excel spreadsheet; the outcomes were evaluated using the Cochrane RoB 2 tool, and the quality of evidence, using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system.<\/jats:p><jats:p>\n          Results\u2003Of the 2,230 articles identified, only 5 were included, totaling 242 participants. In them, pregabalin was slightly less efficacious than amitriptyline, the combination of tramadol\/acetaminophen, and celecoxib, and pregabalin added to celecoxib showed no benefit when compared to celecoxib alone (very low evidence for all). On the other hand, although one study with gabapentin did not support its use in a general sample of patients with low back pain, another found a reduction in the pain scale and improved mobility (moderate evidence). No serious adverse events were observed in any of the studies.<\/jats:p><jats:p>\n          Conclusion\u2003Quality information to support the use of pregabalin or gabapentin in the treatment of CLBP without radiculopathy or neuropathy is lacking, although results may suggest gabapentin as a viable option. More data is needed to fill this current gap in knowledge.<\/jats:p>","DOI":"10.1055\/s-0043-1764414","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T22:52:42Z","timestamp":1687992762000},"page":"564-576","source":"Crossref","is-referenced-by-count":10,"title":["Pregabalin and gabapentin for chronic low back pain without radiculopathy: a systematic review"],"prefix":"10.1055","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4373-1888","authenticated-orcid":false,"given":"Rafael Trindade","family":"Tatit","sequence":"additional","affiliation":[{"name":"Faculdade Israelita de Ci\u00eancias da Sa\u00fade Albert Einstein, Departamento de Medicina, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3262-9378","authenticated-orcid":false,"given":"Arthur Werner","family":"Poetscher","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, Programa Locomotor, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9764-0669","authenticated-orcid":false,"given":"Carlos Augusto Cardim de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Faculdade Israelita de Ci\u00eancias da Sa\u00fade Albert Einstein, Departamento de Medicina, S\u00e3o Paulo SP, Brazil."},{"name":"Universidade da Regi\u00e3o de Joinville, Departamento de Medicina, Joinville SC, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1136\/bmj.332.7555.1430","article-title":"Diagnosis and treatment of low back pain","volume":"332","author":"B W Koes","year":"2006","journal-title":"BMJ"},{"issue":"21","key":"ref2","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1097\/BRS.0000000000001061","article-title":"2015 Updated Method Guideline for Systematic Reviews in the Cochrane Back and Neck Group","volume":"40","author":"A D Furlan","year":"2015","journal-title":"Spine"},{"issue":"06","key":"ref3","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1002\/art.34347","article-title":"A systematic review of the global prevalence of low back pain","volume":"64","author":"D Hoy","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1590\/bjpt-rbf.2014.0149","article-title":"Musculoskeletal pain in children and adolescents","volume":"20","author":"S J Kamper","year":"2016","journal-title":"Braz J Phys Ther"},{"issue":"05","key":"ref5","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s00586-003-0542-y","article-title":"Back pain remains a common symptom in old age. a population-based study of 4486 Danish twins aged 70-102","volume":"12","author":"J Hartvigsen","year":"2003","journal-title":"Eur Spine J"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0140-6736(16)31460-X","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"N J Kassebaum","year":"2016","journal-title":"Lancet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(16)31678-6","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"T Vos","year":"2016","journal-title":"Lancet"},{"issue":"17","key":"ref8","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1097\/00007632-199809010-00012","article-title":"The Saskatchewan health and back pain survey. The prevalence of low back pain and related disability in Saskatchewan adults","volume":"23","author":"J D Cassidy","year":"1998","journal-title":"Spine"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1097\/00007632-198704000-00013","article-title":"Descriptive epidemiology of low-back pain and its related medical care in the United States","volume":"12","author":"R A Deyo","year":"1987","journal-title":"Spine"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1136\/bmj.327.7410.323","article-title":"Acute low back pain: systematic review of its prognosis","volume":"327","author":"L HM Pengel","year":"2003","journal-title":"BMJ"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1136\/bmj.316.7141.1356","article-title":"Outcome of low back pain in general practice: a prospective study","volume":"316","author":"P R Croft","year":"1998","journal-title":"BMJ"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0140-6736(21)00733-9","article-title":"Low back pain","volume":"398","author":"N N Knezevic","year":"2021","journal-title":"Lancet"},{"issue":"06","key":"ref13","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1177\/147323001003800629","article-title":"Prevalence of neuropathic pain among patients with chronic low-back pain in the Arabian Gulf Region assessed using the leeds assessment of neuropathic symptoms and signs pain scale","volume":"38","author":"W El Sissi","year":"2010","journal-title":"J Int Med Res"},{"issue":"07","key":"ref14","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.pain.2011.02.033","article-title":"Identifying neuropathic back and leg pain: a cross-sectional study","volume":"152","author":"I D Beith","year":"2011","journal-title":"Pain"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/pme.12229","article-title":"What is the evidence that neuropathic pain is present in chronic low back pain and soft tissue syndromes? 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