{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:22:52Z","timestamp":1777414972824,"version":"3.51.4"},"reference-count":47,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T00:00:00Z","timestamp":1681430400000},"content-version":"vor","delay-in-days":44,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Deep Brain Stimulation (DBS) is an established treatment option for refractory dystonia, but the improvement among the patients is variable.<\/jats:p><jats:p>\n          Objective\u2003To describe the outcomes of DBS of the subthalamic region (STN) in dystonic patients and to determine whether the volume of tissue activated (VTA) inside the STN or the structural connectivity between the area stimulated and different regions of the brain are associated with dystonia improvement.<\/jats:p><jats:p>\n          Methods\u2003The response to DBS was measured by the Burke-Fahn-Marsden Dystonia Rating Scale (BFM) before and 7 months after surgery in patients with generalized isolated dystonia of inherited\/idiopathic etiology. The sum of the two overlapping STN volumes from both hemispheres was correlated with the change in BFM scores to assess whether the area stimulated inside the STN affects the clinical outcome. Structural connectivity estimates between the VTA (of each patient) and different brain regions were computed using a normative connectome taken from healthy subjects.<\/jats:p><jats:p>\n          Results\u2003Five patients were included. The baseline BFM motor and disability subscores were 78.30\u2009\u00b1\u200913.55 (62.00\u201398.00) and 20.60\u2009\u00b1\u20097.80 (13.00\u201332.00), respectively. Patients improved dystonic symptoms, though differently. No relationships were found between the VTA inside the STN and the BFM improvement after surgery (p\u2009=\u20090.463). However, the connectivity between the VTA and the cerebellum structurally correlated with dystonia improvement (p\u2009=\u20090.003).<\/jats:p><jats:p>\n          Conclusions\u2003These data suggest that the volume of the stimulated STN does not explain the variance in outcomes in dystonia. Still, the connectivity pattern between the region stimulated and the cerebellum is linked to outcomes of patients.<\/jats:p>","DOI":"10.1055\/s-0043-1764416","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T23:57:07Z","timestamp":1681516627000},"page":"263-270","source":"Crossref","is-referenced-by-count":3,"title":["Exploring clinical outcomes in patients with idiopathic\/inherited isolated generalized dystonia and stimulation of the subthalamic region"],"prefix":"10.1055","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7660-3970","authenticated-orcid":false,"given":"Clarice","family":"Listik","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Center for Movement Disorders, Faculty of Medicine, Department of Neurology, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7417-6995","authenticated-orcid":false,"given":"Jorge Dornellys","family":"Lapa","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculty of Medicine, Neurosurgery Division, Departament of de Neurology, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7735-0701","authenticated-orcid":false,"given":"Sara Carvalho Barbosa","family":"Casagrande","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Center for Movement Disorders, Faculty of Medicine, Department of Neurology, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6996-9130","authenticated-orcid":false,"given":"Egberto Reis","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Center for Movement Disorders, Faculty of Medicine, Department of Neurology, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2265-4382","authenticated-orcid":false,"given":"Ricardo","family":"Iglesio","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculty of Medicine, Neurosurgery Division, Departament of de Neurology, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7100-4303","authenticated-orcid":false,"given":"Fabio","family":"Godinho","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculty of Medicine, Neurosurgery Division, Departament of de Neurology, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3310-5346","authenticated-orcid":false,"given":"Kleber Paiva","family":"Duarte","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculty of Medicine, Neurosurgery Division, Departament of de Neurology, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7974-6045","authenticated-orcid":false,"given":"Manoel Jacobsen","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Faculty of Medicine, Neurosurgery Division, Departament of de Neurology, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2113-2187","authenticated-orcid":false,"given":"Rubens Gisbert","family":"Cury","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Center for Movement Disorders, Faculty of Medicine, Department of Neurology, S\u00e3o Paulo SP, 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