{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:54:51Z","timestamp":1790196891479,"version":"4.1.0"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":49,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sleep Sci"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objetive\u2003The aim of this systematic review is to analyze the recent scientific evidence of the clinical effects of altitude on breathing during sleep in healthy persons and sleep disordered patients.<\/jats:p>\n                  <jats:p>Material and Methods\u2003A search was carried out in PubMed and Scopus looking for articles published between January 1, 2010 and December 31, 2021, in English and Spanish, with the following search terms: \u201csleep disorders breathing and altitude\u201d. Investigations in adults and carried out at an altitude of 2000 meters above mean sea level (MAMSL) or higher were included. The correlation between altitude, apnea hypopnea index (AHI) and mean SpO2 during sleep was calculated.<\/jats:p>\n                  <jats:p>Results\u200318 articles of the 112 identified were included. A good correlation was found between altitude and AHI (Rs\u2009=\u20090.66 P\u2009=\u20090.001), at the expense of an increase in the central apnea index. Altitude is inversely proportional to oxygenation during sleep (Rs\u2009=\u2009\u22120.93 P\u2009=\u20090.001), and an increase in the desaturation index was observed (3% and 4%). On the treatment of respiratory disorders of sleeping at altitude, oxygen is better than servoventilation to correct oxygenation during sleep in healthy subjects and acetazolamide controlled respiratory events and oxygenation during sleep in patients with obstructive sleep apnea under treatment with CPAP.<\/jats:p>\n                  <jats:p>Conclusions\u2003Altitude increases AHI and decreases oxygenation during sleep; oxygen and acetazolamide could be an effective treatment for sleep-disordered breathing at altitude above 2000 MAMSL.<\/jats:p>","DOI":"10.1055\/s-0043-1767745","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T18:34:18Z","timestamp":1681929258000},"page":"117-126","source":"Crossref","is-referenced-by-count":13,"title":["Altitude and Breathing during Sleep in Healthy Persons and Sleep Disordered Patients: A Systematic Review"],"prefix":"10.1055","volume":"16","author":[{"given":"Stephanie","family":"Rojas-C\u00f3rdova","sequence":"additional","affiliation":[{"name":"La Portada Municipal Hospital, Pulmonology Service, La Paz, La Paz, Bolivia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha Guadalupe","family":"Torres-Fraga","sequence":"additional","affiliation":[{"name":"National Institute of Respiratory Diseases, Sleep Medicine Unit, Mexico City, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadira Guadalupe","family":"Rodr\u00edguez-Reyes","sequence":"additional","affiliation":[{"name":"National Institute of Respiratory Diseases, Sleep Medicine Unit, Mexico City, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selene","family":"Guerrero-Z\u00fa\u00f1iga","sequence":"additional","affiliation":[{"name":"National Institute of Respiratory Diseases, Sleep Medicine Unit, Mexico City, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"V\u00e1zquez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"National Institute of Respiratory Diseases, Sleep Medicine Unit, Mexico City, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Carrillo-Alduenda","sequence":"additional","affiliation":[{"name":"National Institute of Respiratory Diseases, Sleep Medicine Unit, Mexico City, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,4,19]]},"reference":[{"issue":"S 27","key":"ref1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/(SICI)1096-8644(1998)107:27+<25::AID-AJPA3>3.0.CO;2-L","article-title":"Human adaptation to high altitude: regional and life-cycle perspectives","volume":"27","author":"L G Moore","year":"1998","journal-title":"Am J Phys 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