{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T03:42:09Z","timestamp":1768794129526,"version":"3.49.0"},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":49,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sleep Sci"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Blepharospasm is a focal dystonia that affects the orbicularis oculi muscles. The interest in nonmotor symptoms is due to their impact on quality of life.<\/jats:p><jats:p>\n          Objective\u2003We evaluated the frequency of sleep disorders and circadian rhythm in a sample of Brazilian blepharospasm patients.<\/jats:p><jats:p>\n          Methods\u2003A total of 51 patients, who met the clinical criteria for blepharospasm, evaluated by 2 specialists in movement disorders, were recruited from the outpatient clinic for movement disorders of two reference centers in the city of S\u00e3o Paulo: Universidade Federal de S\u00e3o Paulo and Hospital do Servidor P\u00fablico do Estado de S\u00e3o Paulo. The selected 13 patients were evaluated from 13 days before to 13 days after using botulinum toxin. They were interviewed, underwent physical examination and actigraphy, and completed sleep diaries.<\/jats:p><jats:p>\n          Results\u2003After using botulinum toxin, the group that reported sleep improvement exhibited a 50% decrease in sleep latency. There was no change in restless leg syndrome or circadian rhythm. Patients who reported no sleep improvement after using botulinum toxin presented poorer synchronization of the light-dark cycle.<\/jats:p><jats:p>\n          Conclusion\u2003Blepharospasm patients have poor sleep quality. About 50% of the patients had sleep improvement after using botulinum toxin. The synchronization of the light-dark cycle should be influenced by this finding.<\/jats:p>","DOI":"10.1055\/s-0043-1767753","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T22:34:18Z","timestamp":1681943658000},"page":"038-043","source":"Crossref","is-referenced-by-count":2,"title":["Blepharospasm Patients after Botulinum Toxin \u2013 Sleep Approach"],"prefix":"10.1055","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7511-1686","authenticated-orcid":false,"given":"Silvia","family":"Lestingi","sequence":"additional","affiliation":[{"name":"UNIFESP, Neurologia e Neurocirurgia, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6828-5132","authenticated-orcid":false,"given":"Lenise","family":"Kim","sequence":"additional","affiliation":[{"name":"UNIFESP, Psicobiologia, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5797-7005","authenticated-orcid":false,"given":"Bruno da Silva Brand\u00e3o","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Escola of Artes, Ci\u00eancias e Humanidades, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9937-2175","authenticated-orcid":false,"given":"Sonia Maria Azevedo","family":"Silva","sequence":"additional","affiliation":[{"name":"UNIFESP, Neurologia e Neurocirurgia, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"Hospital do Servidor P\u00fablico Estadual de S\u00e3o Paulo, Departamento de Neurologia, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3821-1407","authenticated-orcid":false,"given":"Henrique","family":"Ferraz","sequence":"additional","affiliation":[{"name":"UNIFESP, Neurologia e Neurocirurgia, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8482-3754","authenticated-orcid":false,"given":"Fernando Morgadinho","family":"Coelho","sequence":"additional","affiliation":[{"name":"UNIFESP, Neurologia e Neurocirurgia, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"},{"name":"UNIFESP, Psicobiologia, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8723-2757","authenticated-orcid":false,"given":"Vanderci","family":"Borges","sequence":"additional","affiliation":[{"name":"UNIFESP, Neurologia e Neurocirurgia, S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,4,19]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/mds.26934","article-title":"Blepharospasm 40 years later","volume":"32","author":"G Defazio","year":"2017","journal-title":"Mov Disord"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"e0209558.","DOI":"10.1371\/journal.pone.0209558","article-title":"Epidemiology of benign essential blepharospasm: A nationwide population-based retrospective study in Taiwan","volume":"13","author":"Y Sun","year":"2018","journal-title":"PLoS One"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/IIO.0000000000000207","article-title":"Benign Essential Blepharospasm: What We Know and What We Don't","volume":"58","author":"C J Hwang","year":"2018","journal-title":"Int Ophthalmol Clin"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/j.1468-1331.2009.02884.x","article-title":"Quality of sleep in primary focal dystonia: a case-control study","volume":"17","author":"L Avanzino","year":"2010","journal-title":"Eur J Neurol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.smrv.2015.04.004","article-title":"Sleep in patients with primary dystonia: A systematic review on the state of research and perspectives","volume":"26","author":"E Hertenstein","year":"2016","journal-title":"Sleep Med Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.smrv.2014.06.002","article-title":"A fresh look at the use of nonparametric analysis in actimetry","volume":"20","author":"B S Gon\u00e7alves","year":"2015","journal-title":"Sleep Med Rev"},{"issue":"07","key":"ref7","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/mds.25475","article-title":"Phenomenology and classification of dystonia: a consensus update","volume":"28","author":"A Albanese","year":"2013","journal-title":"Mov Disord"},{"issue":"16","key":"ref8","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1212\/01.wnl.0000327601.46315.85","article-title":"Update on blepharospasm: report from the BEBRF International Workshop","volume":"71","author":"M Hallett","year":"2008","journal-title":"Neurology"},{"issue":"03","key":"ref9","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1468-1331.2010.03161.x","article-title":"Clinical features of patients with blepharospasm: a report of 240 patients","volume":"18","author":"E L Peckham","year":"2011","journal-title":"Eur J Neurol"},{"issue":"05","key":"ref10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3341\/kjo.2018.0038","article-title":"Clinical Features of Benign Essential Blepharospasm in Korean Patients","volume":"32","author":"J M Lee","year":"2018","journal-title":"Korean J Ophthalmol"},{"issue":"08","key":"ref11","doi-asserted-by":"crossref","first-page":"e0160867.","DOI":"10.1371\/journal.pone.0160867","article-title":"Screening for Cognitive Impairments in Primary Blepharospasm","volume":"11","author":"J Yang","year":"2016","journal-title":"PLoS One"},{"issue":"08","key":"ref12","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.sdentj.2021.07.001","article-title":"Botulinum toxin and occlusal splints for the management of sleep bruxism in individuals with implant overdentures: A randomized controlled trial","volume":"33","author":"S M Ali","year":"2021","journal-title":"Saudi Dent J"},{"issue":"25","key":"ref13","doi-asserted-by":"crossref","first-page":"e26356.","DOI":"10.1097\/MD.0000000000026356","article-title":"Cortical somatosensory processing after botulinum toxin therapy in post-stroke spasticity","volume":"100","author":"T Veverka","year":"2021","journal-title":"Medicine (Baltimore)"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.clineuro.2018.06.040","article-title":"Health-related quality of life outcomes from botulinumtoxin treatment in blepharospasm","volume":"172","author":"D Weiss","year":"2018","journal-title":"Clin Neurol Neurosurg"}],"container-title":["Sleep Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1767753.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T17:54:21Z","timestamp":1690394061000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1767753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":14,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2023,4,19]]},"published-print":{"date-parts":[[2023,3]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1767753","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1984-0659","1984-0063"],"issn-type":[{"value":"1984-0659","type":"print"},{"value":"1984-0063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]}}}