{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:48:37Z","timestamp":1790984917519,"version":"4.1.0"},"reference-count":95,"publisher":"Georg Thieme Verlag KG","issue":"07","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The human gut microbiota is a complex ecosystem made of trillions of microorganisms. The composition can be affected by diet, metabolism, age, geography, stress, seasons, temperature, sleep, and medications. The increasing evidence about the existence of a close and bi-directional correlation between the gut microbiota and the brain indicates that intestinal imbalance may play a vital role in the development, function, and disorders of the central nervous system. The mechanisms of interaction between the gut-microbiota on neuronal activity are widely discussed. Several potential pathways are involved with the brain-gut-microbiota axis, including the vagus nerve, endocrine, immune, and biochemical pathways. Gut dysbiosis has been linked to neurological disorders in different ways that involve activation of the hypothalamic-pituitary-adrenal axis, imbalance in neurotransmitter release, systemic inflammation, and increase in the permeability of the intestinal and the blood-brain barrier. Mental and neurological diseases have become more prevalent during the coronavirus disease 2019pandemic and are an essential issue in public health globally. Understanding the importance of diagnosing, preventing, and treating dysbiosis is critical because gut microbial imbalance is a significant risk factor for these disorders. This review summarizes evidence demonstrating the influence of gut dysbiosis on mental and neurological disorders.<\/jats:p>","DOI":"10.1055\/s-0043-1767818","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T18:56:30Z","timestamp":1688496990000},"page":"670-684","source":"Crossref","is-referenced-by-count":51,"title":["The brain-gut-microbiota axis in the treatment of neurologic and psychiatric disorders"],"prefix":"10.1055","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8773-811X","authenticated-orcid":false,"given":"Maria Fernanda","family":"Naufel","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Departamento de Fisiologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2051-8259","authenticated-orcid":false,"given":"Giselle de Martin","family":"Truzzi","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Departamento de Psicobiologia, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3484-2081","authenticated-orcid":false,"given":"Caroline Marcantonio","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Departamento de Ci\u00eancias Farmac\u00eauticas, S\u00e3o Paulo SP, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8482-3754","authenticated-orcid":false,"given":"Fernando Morgadinho Santos","family":"Coelho","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Departamento de Psicobiologia, S\u00e3o Paulo SP, Brazil."},{"name":"Universidade Federal de S\u00e3o Paulo, Departamento de Neurologia e Neurocirurgia, S\u00e3o Paulo SP, 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Parkinsons Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.1038\/ncomms4611","article-title":"The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism","volume":"5","author":"G Frost","year":"2014","journal-title":"Nat Commun"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"151","DOI":"10.3389\/fcimb.2020.00151","article-title":"Current Sampling Methods for Gut Microbiota: A Call for More Precise Devices","volume":"10","author":"Q Tang","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"issue":"11","key":"ref9","first-page":"87","article-title":"Determining Gut Microbial Dysbiosis: a Review of Applied Indexes for Assessment of Intestinal Microbiota Imbalances","volume":"87","author":"S Wei","year":"2021","journal-title":"Appl Environ Microbiol"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/1751-7915.13479","article-title":"Problems with the concept of gut 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Chen","year":"2021","journal-title":"Nutrients"},{"issue":"04","key":"ref14","first-page":"398","article-title":"Aducanumab: Appropriate Use Recommendations","volume":"8","author":"J Cummings","year":"2021","journal-title":"J Prev Alzheimers Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"879491","DOI":"10.3389\/fpsyt.2022.879491","article-title":"A Systematic Review on the Effects of Different Types of Probiotics in Animal Alzheimer's Disease Studies","volume":"13","author":"T J de Rijke","year":"2022","journal-title":"Front Psychiatry"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3233\/JPD-202237","article-title":"The Gut Mycobiome in Parkinson's Disease","volume":"11","author":"M S Cirstea","year":"2021","journal-title":"J Parkinsons Dis"},{"issue":"06","key":"ref17","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2016.11.018","article-title":"Gut Microbiota Regulate Motor Deficits and 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Reynolds","year":"2017","journal-title":"Sleep Med Rev"},{"issue":"11","key":"ref33","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1038\/s41380-021-01113-1","article-title":"Gut microbiota modulates the inflammatory response and cognitive impairment induced by sleep deprivation","volume":"26","author":"Z Wang","year":"2021","journal-title":"Mol Psychiatry"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.3389\/fmicb.2018.02013","article-title":"Effects of Psychological, Environmental and Physical Stressors on the Gut Microbiota","volume":"9","author":"J P Karl","year":"2018","journal-title":"Front Microbiol"},{"issue":"10","key":"ref35","doi-asserted-by":"crossref","first-page":"e0222394","DOI":"10.1371\/journal.pone.0222394","article-title":"Gut microbiome diversity is associated with sleep physiology in humans","volume":"14","author":"R P Smith","year":"2019","journal-title":"PLoS 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Are Altered in Sleep Disorder of Children With Autism Spectrum Disorders","volume":"11","author":"X Hua","year":"2020","journal-title":"Front Psychiatry"},{"issue":"06","key":"ref43","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1212\/NXI.0000000000000896","article-title":"Gut microbiota composition is associated with narcolepsy type 1","volume":"7","author":"A Lecomte","year":"2020","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"08","key":"ref44","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/nu12082198","article-title":"Sleep and Microbiome in Psychiatric Diseases","volume":"12","author":"J Wagner-Skacel","year":"2020","journal-title":"Nutrients"},{"key":"ref45","volume-title":"Depression and Other Common Mental Disorders Global Health Estimates","author":"W H Organization","year":"2017"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"565688","DOI":"10.3389\/fpsyg.2020.565688","article-title":"A Longitudinal Study on the Emotional Impact Cause by the COVID-19 Pandemic Quarantine on General Population","volume":"11","author":"L Canet-Juric","year":"2020","journal-title":"Front Psychol"},{"issue":"11","key":"ref47","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.euroneuro.2013.05.001","article-title":"Side effects of antidepressants during long-term use in a naturalistic setting","volume":"23","author":"P M Bet","year":"2013","journal-title":"Eur Neuropsychopharmacol"},{"issue":"07","key":"ref48","doi-asserted-by":"crossref","first-page":"e027837","DOI":"10.1136\/bmjopen-2018-027837","article-title":"Helping people discontinue long-term antidepressants: views of health professionals in UK primary care","volume":"9","author":"H M Bowers","year":"2019","journal-title":"BMJ Open"},{"issue":"08","key":"ref49","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1097\/PSY.0000000000000519","article-title":"Brain-Gut-Microbiota Axis and Mental Health","volume":"79","author":"T G Dinan","year":"2017","journal-title":"Psychosom Med"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"721126","DOI":"10.3389\/fneur.2021.721126","article-title":"The Relationship Between the Gut Microbiome-Immune System-Brain Axis and Major Depressive Disorder","volume":"12","author":"J A Foster","year":"2021","journal-title":"Front Neurol"},{"issue":"20","key":"ref51","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/ijms21207551","article-title":"Gut-Brain Axis: Role of Gut Microbiota on Neurological Disorders and How Probiotics\/Prebiotics Beneficially Modulate Microbial and Immune Pathways to Improve Brain Functions","volume":"21","author":"K Suganya","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"109951","DOI":"10.1016\/j.pnpbp.2020.109951","article-title":"The HPA axis dysregulation in severe mental illness: Can we shift the blame to gut microbiota?","volume":"102","author":"B Misiak","year":"2020","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"03","key":"ref53","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/ph11030063","article-title":"Role of Microbiota and Tryptophan Metabolites in the Remote Effect of Intestinal Inflammation on Brain and Depression","volume":"11","author":"B Waclawikov\u00e1","year":"2018","journal-title":"Pharmaceuticals (Basel)"},{"issue":"10","key":"ref54","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1111\/j.1572-0241.2000.03177.x","article-title":"Serotonin: a mediator of the brain-gut connection","volume":"95","author":"D Y Kim","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.brainres.2018.03.015","article-title":"Neurotransmitter modulation by the gut microbiota","volume":"1693","author":"P Strandwitz","year":"2018","journal-title":"Brain Res"},{"issue":"04","key":"ref56","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1053\/gast.2002.32392","article-title":"Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?","volume":"122","author":"W E Whitehead","year":"2002","journal-title":"Gastroenterology"},{"issue":"01","key":"ref57","doi-asserted-by":"crossref","first-page":"13","DOI":"10.5498\/wjp.v2.i1.13","article-title":"Childhood stressful events, HPA axis and anxiety disorders","volume":"2","author":"C Faravelli","year":"2012","journal-title":"World J Psychiatry"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3389\/fcimb.2017.00489","article-title":"Microbiota Modulate Anxiety-Like Behavior and Endocrine Abnormalities in Hypothalamic-Pituitary-Adrenal Axis","volume":"7","author":"R Huo","year":"2017","journal-title":"Front Cell Infect Microbiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2014.07.027","article-title":"Serotonin, tryptophan metabolism and the brain-gut-microbiome axis","volume":"277","author":"S M O'Mahony","year":"2015","journal-title":"Behav Brain Res"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"649103","DOI":"10.3389\/fcell.2021.649103","article-title":"Brain Neurotransmitter Modulation by Gut Microbiota in Anxiety and Depression","volume":"9","author":"F Huang","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"11","key":"ref61","doi-asserted-by":"crossref","first-page":"6459","DOI":"10.1128\/AEM.70.11.6459-6465.2004","article-title":"Real-time PCR quantitation of clostridia in feces of autistic children","volume":"70","author":"Y Song","year":"2004","journal-title":"Appl Environ Microbiol"},{"issue":"03","key":"ref62","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/nu12030792","article-title":"Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis","volume":"12","author":"L Iglesias-V\u00e1zquez","year":"2020","journal-title":"Nutrients"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"105840","DOI":"10.1016\/j.phrs.2021.105840","article-title":"The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders","volume":"172","author":"K Soca\u0142a","year":"2021","journal-title":"Pharmacol Res"},{"issue":"03","key":"ref64","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/schbul\/sbt006","article-title":"Psychiatric disorders in toxoplasma seropositive patients\u2013the CD8 connection","volume":"39","author":"R Bhadra","year":"2013","journal-title":"Schizophr Bull"},{"issue":"05","key":"ref65","doi-asserted-by":"crossref","first-page":"559","DOI":"10.2174\/1570159X15666170915141036","article-title":"The Microbiota-Gut-Brain Axis in Neuropsychiatric Disorders: Pathophysiological Mechanisms and Novel Treatments","volume":"16","author":"Y K Kim","year":"2018","journal-title":"Curr Neuropharmacol"},{"issue":"01","key":"ref66","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/bdi.12682","article-title":"A step ahead: Exploring the gut microbiota in inpatients with bipolar disorder during a depressive episode","volume":"21","author":"A Painold","year":"2019","journal-title":"Bipolar Disord"},{"issue":"05","key":"ref67","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/bdi.12416","article-title":"Individuals hospitalized with acute mania have increased exposure to antimicrobial medications","volume":"18","author":"R Yolken","year":"2016","journal-title":"Bipolar Disord"},{"issue":"10","key":"ref68","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/microorganisms9102066","article-title":"Risk Factors for Gut Dysbiosis in Early Life","volume":"9","author":"K Parkin","year":"2021","journal-title":"Microorganisms"},{"issue":"03","key":"ref69","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s13668-020-00313-5","article-title":"Probiotics and the Microbiota-Gut-Brain Axis: Focus on Psychiatry","volume":"9","author":"S M\u00f6rkl","year":"2020","journal-title":"Curr Nutr Rep"},{"issue":"04","key":"ref70","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.arr.2011.03.001","article-title":"Impact of \u03c9-3 fatty acids in Parkinson's disease","volume":"10","author":"M Bousquet","year":"2011","journal-title":"Ageing Res Rev"},{"issue":"10","key":"ref71","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1172\/JCI72333","article-title":"Antibiotics and the gut microbiota","volume":"124","author":"S R Modi","year":"2014","journal-title":"J Clin Invest"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"212553","DOI":"10.7573\/dic.212553","article-title":"The therapeutic role of minocycline in Parkinson's disease","volume":"8","author":"S Cankaya","year":"2019","journal-title":"Drugs Context"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejim.2020.12.023","article-title":"The Brain-Gut-Microbiotal Axis: A framework for understanding functional GI illness and their therapeutic interventions","volume":"84","author":"C Tait","year":"2021","journal-title":"Eur J Intern Med"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1146\/annurev-pharmtox-010919-023628","article-title":"Microbiota-Gut-Brain Axis: New Therapeutic Opportunities","volume":"60","author":"C Long-Smith","year":"2020","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"03","key":"ref75","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.clnu.2018.05.018","article-title":"Clinical and metabolic response to probiotic administration in people with Parkinson's disease: A randomized, double-blind, placebo-controlled 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