{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T16:04:01Z","timestamp":1791734641102,"version":"4.3.4"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Pediatr Surg"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objectives\u2003Nutritional support during the neonatal and postoperative period in congenital diaphragmatic hernia (CDH) is challenging and controversial. We aimed to report on early enteral nutritional support in symptomatic CDH patients during the pre- and postoperative period, including feasibility, associated factors with established full enteral nutrition, and weight at birth, discharge, and 18 months.<\/jats:p>\n                  <jats:p>Methods\u2003We retrospectively collected data on nutrition: type and volume of enteral nutrition and parental support. Enteral feeding was introduced preoperatively from day 1 after birth, increased step-wised (breastmilk preferred), and resumed after CDH repair on the first postoperative day. Baseline data were available from our CDH database.<\/jats:p>\n                  <jats:p>Results\u2003From 2011 to 2020, we identified 45 CDH infants. Twenty-two were girls (51.1%), 35 left sided (77.8%), and 40 underwent CDH repair (88.9%). Median (interquartile range) length of stay in the pediatric intensive care unit was 14.6 days (6.0\u201326.5), and 1-year mortality was 17.8%.<\/jats:p>\n                  <jats:p>Postoperatively, 120 and 160\u2009mL\/kg\/d of enteral nutrition was achieved after a median of 6.5 (3.6\u201312.6) and 10.6 (7.6\u201321.7) days, respectively. In total, 31 (68.9%) needed supplemental parenteral nutrition in a median period of 8 days (5\u201318), and of those 11 had parenteral nutrition initiated before CDH repair. No complications to enteral feeding were reported.<\/jats:p>\n                  <jats:p>Conclusion\u2003Early enteral nutrition in CDH infants is feasible and may have the potential to reduce the need for parental nutrition and reduce time to full enteral nutrition in the postoperative period.<\/jats:p>","DOI":"10.1055\/s-0043-1767829","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T20:01:17Z","timestamp":1678996877000},"page":"469-476","source":"Crossref","is-referenced-by-count":6,"title":["Early Pre- and Postoperative Enteral Nutrition and Growth in Infants with Symptomatic Congenital Diaphragmatic Hernia"],"prefix":"10.1055","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6986-2907","authenticated-orcid":false,"given":"Ulla Lei","family":"Larsen","sequence":"additional","affiliation":[{"name":"Research Unit for the Department of Anaesthesiology & Intensive Care, Odense University Hospital, University of Southern Denmark, Odense, Denmark"},{"name":"Odense Patient Data Explorative Network (OPEN), Odense University Hospital and Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitte","family":"Zachariassen","sequence":"additional","affiliation":[{"name":"Odense Patient Data Explorative Network (OPEN), Odense University Hospital and Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"H.C. Andersen Children's Hospital, Odense University Hospital; Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6ren","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"Odense Patient Data Explorative Network (OPEN), Odense University Hospital and Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelmine Ursin","family":"F\u00f8rre","sequence":"additional","affiliation":[{"name":"Research Unit for the Department of Anaesthesiology & Intensive Care, Odense University Hospital, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingvild","family":"Gr\u00f8sle","sequence":"additional","affiliation":[{"name":"Research Unit for the Department of Anaesthesiology & Intensive Care, Odense University Hospital, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Halken","sequence":"additional","affiliation":[{"name":"H.C. Andersen Children's Hospital, Odense University Hospital; Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Maria","family":"Herskind","sequence":"additional","affiliation":[{"name":"H.C. Andersen Children's Hospital, Odense University Hospital; Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Str\u00f8m","sequence":"additional","affiliation":[{"name":"Research Unit for the Department of Anaesthesiology & Intensive Care, Odense University Hospital, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Anaesthesiology and Intensive Care, Hospital S\u00f8nderjylland, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palle","family":"Toft","sequence":"additional","affiliation":[{"name":"Research Unit for the Department of Anaesthesiology & Intensive Care, Odense University Hospital, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Elleb\u00e6k","sequence":"additional","affiliation":[{"name":"Research Unit for Surgery, Odense University Hospital, University of Southern Denmark, Odense, Denmark"},{"name":"Research Unit for Surgery, and Centre of Excellence in Gastrointestinal Diseases and Malformations in Infancy and Childhood (GAIN), Odense University Hospital, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Qvist","sequence":"additional","affiliation":[{"name":"Odense Patient Data Explorative Network (OPEN), Odense University Hospital and Institute of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"Research Unit for Surgery, Odense University Hospital, University of Southern Denmark, Odense, Denmark"},{"name":"Research Unit for Surgery, and Centre of Excellence in Gastrointestinal Diseases and Malformations in Infancy and Childhood (GAIN), Odense University Hospital, University of Southern Denmark, Odense, 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Moon","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1159\/000320622","article-title":"Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: the CDH EURO Consortium consensus","volume":"98","author":"I Reiss","year":"2010","journal-title":"Neonatology"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1159\/000444210","article-title":"Standardized postnatal management of infants with congenital diaphragmatic hernia in Europe: the CDH EURO Consortium Consensus\u20142015 Update","volume":"110","author":"K G Snoek","year":"2016","journal-title":"Neonatology"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s12262-015-1286-8","article-title":"Current concepts in the management of congenital diaphragmatic hernia in infants","volume":"77","author":"V H 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