{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:16Z","timestamp":1740126856112,"version":"3.37.3"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Several studies have reported high rates of prosthesis\u2013patient mismatch (PPM) after aortic valve replacement (AVR) with the Mosaic prosthesis. This work assesses the incidence of PPM after AVR with a modified version of the Mosaic prosthesis, the Mosaic Ultra.<\/jats:p><jats:p>\n          Methods\u2003We performed a retrospective analysis of the data of 532 patients who underwent AVR with implantation of the Mosaic Ultra prosthesis in the period 2007\u20132016 in our institution. Patients were classified according to their indexed effective orifice area (EOAi) to severe (EOAi\u2009&lt;\u20090.65\u2009cm2\/m2), moderate (EOAi 0.65\u20130.85\u2009cm2\/m2), and absent\/mild PPM (EOAi\u2009&gt;\u20090.85\u2009cm2\/m2). In-hospital postoperative outcomes and the impact of PPM on mean transvalvular pressure gradient after stratification by prosthesis size were assessed.<\/jats:p><jats:p>\n          Results\u2003Overall, 3 (0.6%) patients had severe, 92 (17.3%) moderate, and 437 (82.1%) absent\/mild PPM. There was a significant difference in PPM proportions (moderate\/severe vs absent\/mild PPM) across different prosthesis sizes overall (p\u2009&lt;\u20090.0001), observing gradually increasing rates of PPM with decreasing prosthesis sizes. Patients with moderate\/severe PPM had higher mean transvalvular pressure gradients (19 [13\u201325] vs 13 [10\u201317] mm Hg, p\u2009&lt;\u20090.0001) than patients with absent\/mild PPM. There was a significant difference in mean transvalvular pressure gradient between the different aortic valve prosthesis sizes overall (p\u2009&lt;\u20090.0001), observing gradually increasing gradients with decreasing prosthesis sizes.<\/jats:p><jats:p>\n          Conclusion\u2003Patients undergoing AVR with the smaller sized (19, 21, and 23\u2009mm) Mosaic Ultra aortic valve prostheses exhibit a higher risk for moderate\/severe PPM and higher mean aortic transvalvular pressure gradients than patients receiving the larger sized (25, 27, and 29\u2009mm) prostheses.<\/jats:p>","DOI":"10.1055\/s-0043-1768033","type":"journal-article","created":{"date-parts":[[2023,4,9]],"date-time":"2023-04-09T22:30:33Z","timestamp":1681079433000},"page":"197-204","source":"Crossref","is-referenced-by-count":0,"title":["Prosthesis\u2013Patient Mismatch after Aortic Valve Replacement with the Mosaic Ultra Bioprosthesis"],"prefix":"10.1055","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7910-5152","authenticated-orcid":false,"given":"Omer","family":"Dzemali","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, City Hospital of Zurich, Triemli, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"Haeussler","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, City Hospital of Zurich, Triemli, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8573-1018","authenticated-orcid":false,"given":"Vasileios","family":"Ntinopoulos","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, City Hospital of Zurich, Triemli, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector Rodriguez Cetina","family":"Biefer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, City Hospital of Zurich, Triemli, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stak","family":"Dushaj","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, City Hospital of Zurich, Triemli, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Rings","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, City Hospital of Zurich, Triemli, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philine","family":"Fleckenstein","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, City Hospital of Zurich, Triemli, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,4,9]]},"reference":[{"issue":"02","key":"ref1","first-page":"211","article-title":"Impact of prosthesis-patient mismatch on hemodynamic and 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