{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:58:19Z","timestamp":1781179099239,"version":"3.54.1"},"reference-count":33,"publisher":"Scientific Scholar","issue":"04","license":[{"start":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T00:00:00Z","timestamp":1681084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["South Asian J Cancer"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>Background\u2003Oral cavity cancers require definitive surgical resection as the primary treatment, but with advanced T stage, complete resection with pathologically negative margins might be difficult to achieve. Induction chemotherapy helps achieve the balance between resection and morbidity in locally advanced technically unresectable tumors. The aim of this study was to analyze the impact of surgery in locally advanced, technically unresectable oral cavity cancers after neoadjuvant chemotherapy (NACT).<\/jats:p>\n                  <jats:p>Materials and Methods\u2003A retrospective analysis of patients with borderline resectable, locally advanced oral cavity cancers who were given NACT between February 2017 and December 2021 was conducted. Data regarding clinical and pathological characteristics, NACT, surgery, adjuvant therapy, and recurrences was analyzed.<\/jats:p>\n                  <jats:p>Results\u2003Of the 69 patients in the study, 69.6% had tongue cancer, rest were gingivobuccal complex cancers. All tumors were resected based on the post-NACT tumor volume and clear margins were achieved in 42% of cases. About 85.4% of the tongue cancers required a lesser resection than anticipated, thereby following the concept of organ and functional preservation post-NACT as proposed by Licitra et al. About 30.4% had ypT0 and 17.4% had ypN0. Recurrence and survival rates noted in our study were comparable to those reported in literature. Lymph node density of more than or equal to 0.07 was found in all recurrent cases.<\/jats:p>\n                  <jats:p>Conclusions\u2003Induction chemotherapy offers a chance of achieving adequate surgical resection while reducing morbidity and improving functional outcomes for patients with technically unresectable oral cavity cancers. Nodal disease may not respond to chemotherapy as well as the primary tumor. There is a need for comprehensive evaluation of prognostic factors, which could help identify the patients who will most benefit with NACT.<\/jats:p>","DOI":"10.1055\/s-0043-1768038","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T18:47:45Z","timestamp":1681152465000},"page":"341-348","source":"Crossref","is-referenced-by-count":8,"title":["Definitive Surgery after Neoadjuvant Chemotherapy for Locally Advanced Oral Cavity Cancers: Experience from a Tertiary Care Center"],"prefix":"10.25259","volume":"12","author":[{"given":"Mansi","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Unit-2, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0062-4713","authenticated-orcid":false,"given":"Vidya","family":"Konduru","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Unit-2, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeyashanth","family":"Riju","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Unit-2, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjana","family":"Joel","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reka","family":"Karuppusami","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit Jiwan","family":"Tirkey","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Unit-2, Christian Medical College, Vellore, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2023,4,10]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0030-4220(90)90294-3","article-title":"Oral cancer in India: an epidemiologic and clinical review","volume":"69","author":"R Sankaranarayanan","year":"1990","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1016\/S0140-6736(05)66658-5","article-title":"Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial","volume":"365","author":"R Sankaranarayanan","year":"2005","journal-title":"Lancet"},{"issue":"09","key":"ref3","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.oraloncology.2013.05.010","article-title":"Consensus recommendations for management of head and neck cancer in Asian countries: a review of international guidelines","volume":"49","author":"A D'cruz","year":"2013","journal-title":"Oral Oncol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.oraloncology.2009.01.004","article-title":"Oral squamous cell carcinoma overview","volume":"45","author":"C Scully","year":"2009","journal-title":"Oral Oncol"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","article-title":"Global cancer statistics, 2002","volume":"55","author":"D M Parkin","year":"2005","journal-title":"CA Cancer J Clin"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"701932","DOI":"10.1155\/2012\/701932","article-title":"Challenges of the oral cancer burden in India","volume":"2012","author":"K R Coelho","year":"2012","journal-title":"J Cancer Epidemiol"},{"issue":"01","key":"ref7","first-page":"108","article-title":"Trends of head and neck cancers in urban and rural India","volume":"7","author":"J K Elango","year":"2006","journal-title":"Asian Pac J Cancer Prev"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.oraloncology.2012.03.027","article-title":"Primary chemoradiotherapy for oral cavity squamous cell carcinoma","volume":"48","author":"A K Crombie","year":"2012","journal-title":"Oral Oncol"},{"issue":"05","key":"ref9","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/ssu.2980050506","article-title":"Radiotherapy of carcinoma of the buccal mucosa","volume":"5","author":"A J Chaudhary","year":"1989","journal-title":"Semin Surg Oncol"},{"issue":"05","key":"ref10","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.oraloncology.2005.10.005","article-title":"Carcinoma of the buccal mucosa: analysis of clinical presentation, outcome and prognostic factors","volume":"42","author":"S Ghoshal","year":"2006","journal-title":"Oral Oncol"},{"issue":"08","key":"ref11","doi-asserted-by":"crossref","first-page":"4133","DOI":"10.7314\/APJCP.2012.13.8.4133","article-title":"Survival following non surgical treatments for oral cancer: a single institutional result","volume":"13","author":"M H Larizadeh","year":"2012","journal-title":"Asian Pac J Cancer Prev"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/hed.20279","article-title":"Defining risk levels in locally advanced head and neck cancers: a comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (#22931) and RTOG (# 9501)","volume":"27","author":"J Bernier","year":"2005","journal-title":"Head Neck"},{"issue":"19","key":"ref13","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1056\/NEJMoa032641","article-title":"Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer","volume":"350","author":"J Bernier","year":"2004","journal-title":"N Engl J Med"},{"issue":"05","key":"ref14","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/jso.23724","article-title":"Current treatment of head and neck squamous cell cancer","volume":"110","author":"R Belcher","year":"2014","journal-title":"J Surg Oncol"},{"issue":"17","key":"ref15","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa071028","article-title":"Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer","volume":"357","author":"J B Vermorken","year":"2007","journal-title":"N Engl J Med"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.radonc.2008.06.007","article-title":"Hypofractionated, palliative radiotherapy for advanced head and neck cancer","volume":"89","author":"J P Agarwal","year":"2008","journal-title":"Radiother Oncol"},{"issue":"03","key":"ref17","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.radonc.2004.03.009","article-title":"Short course palliative radiotherapy of 20 Gy in 5 fractions for advanced and incurable head and neck cancer: AIIMS study","volume":"71","author":"B K Mohanti","year":"2004","journal-title":"Radiother Oncol"},{"issue":"02","key":"ref18","doi-asserted-by":"crossref","first-page":"e233","DOI":"10.4317\/medoral.18772","article-title":"Oral cancer: current role of radiotherapy and chemotherapy","volume":"18","author":"S H Huang","year":"2013","journal-title":"Med Oral Patol Oral Cir Bucal"},{"issue":"02","key":"ref19","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/cncr.21984","article-title":"Surgical outcome of T4a and resected T4b oral cavity cancer","volume":"107","author":"C T Liao","year":"2006","journal-title":"Cancer"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1758-3284-2-9","article-title":"Clinicopathological parameters, recurrence, locoregional and distant metastasis in 115 T1-T2 oral squamous cell carcinoma patients","volume":"2","author":"W Jerjes","year":"2010","journal-title":"Head Neck Oncol"},{"issue":"01","key":"ref21","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4103\/0973-1482.95178","article-title":"Cut margins and disease control in oral cancers","volume":"8","author":"S R Priya","year":"2012","journal-title":"J Cancer Res Ther"},{"issue":"01","key":"ref22","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1054\/ijom.2002.0313","article-title":"The prognostic implications of the surgical margin in oral squamous cell carcinoma","volume":"32","author":"D N Sutton","year":"2003","journal-title":"Int J Oral Maxillofac Surg"},{"issue":"04","key":"ref24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/jnci\/86.4.265","article-title":"Phase III trial of initial chemotherapy in stage III or IV head and neck cancers: a study by the Gruppo di Studio sui Tumori della Testa e del Collo","volume":"86","author":"A Paccagnella","year":"1994","journal-title":"J Natl Cancer Inst"},{"issue":"02","key":"ref25","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1200\/JCO.2003.06.146","article-title":"Primary chemotherapy in resectable oral cavity squamous cell cancer: a randomized controlled trial","volume":"21","author":"L Licitra","year":"2003","journal-title":"J Clin Oncol"},{"issue":"06","key":"ref26","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1200\/JCO.2012.43.8820","article-title":"Randomized phase III trial of induction chemotherapy with docetaxel, cisplatin, and fluorouracil followed by surgery versus up-front surgery in locally advanced resectable oral squamous cell carcinoma","volume":"31","author":"L P Zhong","year":"2013","journal-title":"J Clin Oncol"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.oraloncology.2014.07.015","article-title":"Neoadjuvant chemotherapy followed by surgery in very locally advanced technically unresectable oral cavity cancers","volume":"50","author":"V M Patil","year":"2014","journal-title":"Oral Oncol"},{"issue":"05","key":"ref28","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1002\/ssu.2980050505","article-title":"Surgery for cancer of the buccal mucosa","volume":"5","author":"S A Pradhan","year":"1989","journal-title":"Semin Surg Oncol"},{"issue":"17","key":"ref29","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1056\/NEJMoa070956","article-title":"Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer","volume":"357","author":"M R Posner","year":"2007","journal-title":"N Engl J Med"},{"issue":"10","key":"ref30","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1093\/annonc\/mdn364","article-title":"Induction chemotherapy and concurrent chemoradiotherapy for locoregionally advanced head and neck cancer: a multi-institutional phase II trial investigating three radiotherapy dose levels","volume":"19","author":"J K Salama","year":"2008","journal-title":"Ann Oncol"},{"issue":"03","key":"ref31","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S1470-2045(13)70011-1","article-title":"Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial","volume":"14","author":"R Haddad","year":"2013","journal-title":"Lancet Oncol"},{"issue":"08","key":"ref32","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/bjc.2013.570","article-title":"Lymph node density in oral cavity cancer: results of the International Consortium for Outcomes Research","volume":"109","author":"S G Patel","year":"2013","journal-title":"Br J Cancer"},{"key":"ref33","first-page":"259154","article-title":"Is there a limitation of RECIST criteria in prediction of pathological response, in head and neck cancers, to postinduction chemotherapy?","volume":"2013","author":"V Patil","year":"2013","journal-title":"ISRN Oncol"},{"issue":"01","key":"ref34","first-page":"90","article-title":"Using the Common Terminology Criteria for Adverse Events (CTCAE - Version 5.0) to evaluate the severity of adverse events of anticancer therapies","volume":"112","author":"A Freites-Martinez","year":"2021","journal-title":"Actas Dermosifiliogr (Engl Ed)"}],"container-title":["South Asian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1768038.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:12:49Z","timestamp":1781176369000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.sajc.org\/definitive-surgery-after-neoadjuvant-chemotherapy-for-locally-advanced-oral-cavity-cancers-experience-from-a-tertiary-care-center\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,10]]},"references-count":33,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2023,12,20]]},"published-print":{"date-parts":[[2023,10]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1768038","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2278-330X","2278-4306"],"issn-type":[{"value":"2278-330X","type":"print"},{"value":"2278-4306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,10]]}}}