{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T01:08:45Z","timestamp":1784077725883,"version":"3.55.0"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","issue":"07","license":[{"start":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T00:00:00Z","timestamp":1690329600000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Huntington's disease (HD) is an inherited disease that leads to an inexorable progression of motor, cognitive and psychiatric disturbances. In the initial stages, the symptoms are not clearly disabling, and the patient may present a lack of awareness about the symptoms themselves, which we call anosognosia. However, anosognosia might not justify all passivity of the HD patient in face of the diagnosis. Patients may also experience the denial of illness, as a stage of grief, expected to happen in the face of the diagnosis of any neurodegenerative disorder. In addition, people with HD tend to be more apathetic, and more silent, in regular consultations. In the present article, the authors express a point of view, discussing the behavior of the HD patient, in which there is a multifactorial passivity, in the face of the diagnosis and of the disease itself. Having the proper knowledge of this situation may prepare the neurologist to better understand the patient and the evolution of the disease.<\/jats:p>","DOI":"10.1055\/s-0043-1768158","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T22:49:28Z","timestamp":1690411768000},"page":"696-699","source":"Crossref","is-referenced-by-count":3,"title":["\u201cI don't have Huntington's disease\u201d: the boundaries between acceptance and understanding"],"prefix":"10.1055","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0207-3671","authenticated-orcid":false,"given":"Gustavo Leite","family":"Franklin","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1, Departamento de Medicina Interna, Curitiba PR, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2305-1073","authenticated-orcid":false,"given":"H\u00e9lio A. Ghizoni","family":"Teive","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Departamento de Medicina Interna, Servi\u00e7o de Neurologia, Unidade de Dist\u00farbios do Movimento, Curitiba PR, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0808-0116","authenticated-orcid":false,"given":"Francisco Eduardo","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Departamento de Medicina Interna, Servi\u00e7o de Neurologia, Belo Horizonte MG, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,7,26]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/nrneurol.2014.24","article-title":"Huntington's disease: natural history, biomarkers and prospects for therapeutics","volume":"10","author":"C A Ross","year":"2014","journal-title":"Nat Rev Neurol"},{"issue":"01","key":"ref2","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1034\/j.1399-0004.2000.580108.x","article-title":"Atypical movement disorders in the early stages of Huntington's disease: clinical and genetic analysis","volume":"58","author":"F Squitieri","year":"2000","journal-title":"Clin Genet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1590\/s0004-282X2007000300007","article-title":"Non-choreic movement disorders as initial manifestations of Huntington's disease","volume":"65","author":"N Becker","year":"2007","journal-title":"Arq Neuropsiquiatr"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"571843","DOI":"10.3389\/fneur.2020.571843","article-title":"Is Ataxia an Underestimated Symptom of Huntington's Disease?","volume":"11","author":"G L Franklin","year":"2020","journal-title":"Front Neurol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.parkreldis.2022.08.023","article-title":"The burden of Huntington's disease: A prospective longitudinal study of patient\/caregiver pairs","volume":"103","author":"K Youssov","year":"2022","journal-title":"Parkinsonism Relat Disord"},{"issue":"03","key":"ref6","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1002\/mdc3.13174","article-title":"It Is Time to Define Huntington's Disease Onset more Clearly","volume":"8","author":"G L Franklin","year":"2021","journal-title":"Mov Disord Clin Pract (Hoboken)"},{"key":"ref7","first-page":"845","article-title":"Contribution \u00e0 l'\u00e9tude des troubles, mentaux dans l'h\u00e9mipl\u00e9gie organique c\u00e9rebrale (Anosognosie)","volume":"27","author":"J Babinski","year":"1914","journal-title":"Rev Neurol (Paris)"},{"issue":"02","key":"ref8","first-page":"121","article-title":"A variation of Capgras syndrome with anosognosia in Huntington's disease: a case report","volume":"11","author":"F R Frankenburg","year":"1989","journal-title":"Hillside J Clin Psychiatry"},{"issue":"03","key":"ref9","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3233\/JHD-200410","article-title":"The Impact of Anosognosia on Clinical and Patient-Reported Assessments of Psychiatric Symptoms in Huntington's Disease","volume":"9","author":"D Isaacs","year":"2020","journal-title":"J Huntingtons Dis"},{"issue":"13","key":"ref10","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1212\/WNL.0b013e3182a55f05","article-title":"Unawareness of motor phenoconversion in Huntington disease","volume":"81","author":"E A McCusker","year":"2013","journal-title":"Neurology"},{"issue":"12","key":"ref11","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1002\/mds.22601","article-title":"Motor abnormalities in premanifest persons with Huntington's disease: the PREDICT-HD study","volume":"24","author":"K M Biglan","year":"2009","journal-title":"Mov Disord"},{"issue":"02","key":"ref12","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1176\/jnp.2010.22.2.196","article-title":"\u201cFrontal\u201d behaviors before the diagnosis of Huntington's disease and their relationship to markers of disease progression: evidence of early lack of awareness","volume":"22","author":"K Duff","year":"2010","journal-title":"J Neuropsychiatry Clin Neurosci"},{"issue":"01","key":"ref13","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1177\/0891988719856697","article-title":"Anosognosia Is Associated With Greater Caregiver Burden and Poorer Executive Function in Huntington Disease","volume":"33","author":"P Wibawa","year":"2020","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"257","DOI":"10.7916\/D8FJ2FD3","article-title":"The many facets of unawareness in huntington disease","volume":"4","author":"E McCusker","year":"2014","journal-title":"Tremor Other Hyperkinet Mov (N Y)"},{"issue":"02","key":"ref15","doi-asserted-by":"publisher","first-page":"125","DOI":"10.3233\/JHD-140109","article-title":"Unawareness of deficits in Huntington's disease","volume":"3","author":"E J Sitek","year":"2014","journal-title":"J Huntingtons Dis"},{"issue":"01","key":"ref16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/gps.5415","article-title":"Altered awareness of cognitive and neuropsychiatric symptoms in Parkinson's disease and Dementia with Lewy Bodies: A systematic review","volume":"36","author":"C Pennington","year":"2021","journal-title":"Int J Geriatr Psychiatry"},{"issue":"06","key":"ref17","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1590\/0004-282X20160060","article-title":"Presence or absence of cognitive complaints in Parkinson's disease: mood disorder or anosognosia?","volume":"74","author":"P C Castro","year":"2016","journal-title":"Arq Neuropsiquiatr"},{"issue":"05","key":"ref18","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1017\/S1355617711000725","article-title":"Self-awareness of motor dysfunction in patients with Huntington's disease in comparison to Parkinson's disease and cervical dystonia","volume":"17","author":"E J Sitek","year":"2011","journal-title":"J Int Neuropsychol Soc"},{"key":"ref19","volume-title":"On Death and Dying","author":"E Klubler-Ross","year":"1969"},{"issue":"04","key":"ref20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/arclin\/11.4.295","article-title":"Evidence of a neurologically based \u201cdenial of illness\u201d in patients with Huntington's disease","volume":"11","author":"A W Deckel","year":"1996","journal-title":"Arch Clin Neuropsychol"},{"issue":"03","key":"ref21","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1176\/jnp.17.3.378","article-title":"A comparison of self-report and caregiver assessment of depression, apathy, and irritability in Huntington's disease","volume":"17","author":"A Chatterjee","year":"2005","journal-title":"J Neuropsychiatry Clin Neurosci"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1768158.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T22:52:16Z","timestamp":1690411936000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1768158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":21,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2023,7,26]]},"published-print":{"date-parts":[[2023,7]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1768158","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0004-282X","1678-4227"],"issn-type":[{"value":"0004-282X","type":"print"},{"value":"1678-4227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]}}}