{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T05:19:42Z","timestamp":1788067182493,"version":"build-2784847793"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"S 01","funder":[{"name":"Chongqing Medical Research Projects of China","award":["2021MSXM280"],"award-info":[{"award-number":["2021MSXM280"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to explore the efficiency of ultrasound (US) in prenatal diagnosis and prognosis of Pierre Robin sequence (PRS) of 18 cases.<\/jats:p><jats:p>\n            Study Design\u2003A total of 79,305 women admitted for prenatal US examinations were recruited from January 2017 to December 2020. Eighteen cases of PRS fetuses were selected form the cohort and 40 cases of isolated micrognathia were recruited randomly as control group. All the clinical and imaging results were retrospectively reviewed. General condition, US measurements, and prognosis of fetuses were compared between groups.<\/jats:p><jats:p>\n            Results\u2003Cleft palate, glossoptosis, and micrognathia were found in all 18 fetuses with PRS by prenatal US. Compared with the isolated micrognathia group, there were no significant differences in the PRS group in examination of maternal age, gestational weeks at assessment, and gender of fetuses, but significant lower measures in inferior facial angle, jaw index, and frontal nasal\u2013mental angle (each p\u2009&lt;\u20090.05). Twelve fetuses were defined to have other associated malformations. Ear malformations were the most common associated malformations with a prevalence of 44.4% (8\/18). All of the18 cases were confirmed with PRS after delivery or autopsy. Two delivered infants were found bucking easily, one baby was spitting up frequently but growth showed normal.<\/jats:p><jats:p>\n            Conclusion\u2003Prenatal detection of PRS with US examination is highly efficient. Even with the triad of malformations, isolated PRS had good outcomes following initial stabilization and management in the neonatal period. Prenatal detection of Pierre Robin syndrome with targeted US examination is efficient in discerning characteristics of this rare syndrome. Even with the triad of malformations, isolated PRS had good outcomes following initial stabilization and management in the neonatal period.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0043-1768233","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T22:52:51Z","timestamp":1681771971000},"page":"e1639-e1646","source":"Crossref","is-referenced-by-count":6,"special_numbering":"S","title":["Prenatal Diagnosis of Pierre Robin Sequence and Its Prognosis: A Retrospective Cohort Study"],"prefix":"10.1055","volume":"41","author":[{"given":"ChunYan","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Chongqing Health Center for Women and Children, Chongqing, People's Republic of China"},{"name":"Department of Ultrasound, Women and Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaopeng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Chongqing Traditional Chinese Medicine Hospital, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Chongqing Health Center for Women and Children, Chongqing, People's Republic of China"},{"name":"Department of Ultrasound, Women and Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Chongqing Health Center for Women and Children, Chongqing, People's Republic of China"},{"name":"Department of Ultrasound, Women and Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Chongqing Health Center for Women and Children, Chongqing, People's Republic of China"},{"name":"Department of Ultrasound, Women and Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SuZhen","family":"Ran","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Chongqing Health Center for Women and Children, Chongqing, People's Republic of China"},{"name":"Department of Ultrasound, Women and Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"ref1","first-page":"234","volume-title":"Robin sequence","author":"K L Jones","year":"1997"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1597\/02-055","article-title":"Pierre Robin sequence in Denmark: a retrospective population-based epidemiological study","volume":"41","author":"A Printzlau","year":"2004","journal-title":"Cleft Palate Craniofac J"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1750-1172-9-9","article-title":"Birth prevalence and initial treatment of Robin sequence in Germany: a prospective epidemiologic study","volume":"9","author":"S Vatlach","year":"2014","journal-title":"Orphanet J Rare Dis"},{"issue":"02","key":"ref4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cps.2018.11.010","article-title":"Pierre Robin sequence","volume":"46","author":"S T Hsieh","year":"2019","journal-title":"Clin Plast 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prenatal diagnostic predictor of Pierre Robin sequence","volume":"60","author":"M K Bruce","year":"2023","journal-title":"Cleft Palate Craniofac J"},{"issue":"02","key":"ref15","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.joms.2017.07.163","article-title":"Micrognathia and oropharyngeal space in patients with Robin sequence: prenatal MRI measurements","volume":"76","author":"T D Kooiman","year":"2018","journal-title":"J Oral Maxillofac Surg"},{"issue":"04","key":"ref16","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.joms.2019.10.015","article-title":"Can Robin sequence be predicted from prenatal ultrasonography?","volume":"78","author":"J QN Nguyen","year":"2020","journal-title":"J Oral Maxillofac Surg"},{"issue":"04","key":"ref17","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1067\/mpd.2001.117784","article-title":"Pierre Robin sequence: a series of 117 consecutive cases","volume":"139","author":"M Holder-Espinasse","year":"2001","journal-title":"J Pediatr"},{"issue":"02","key":"ref18","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/ajmg.a.35773","article-title":"Developmental outcome in Pierre Robin sequence: a longitudinal and prospective study of a consecutive series of severe phenotypes","volume":"161A","author":"B Thouvenin","year":"2013","journal-title":"Am J Med Genet A"},{"issue":"12","key":"ref19","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1111\/j.1460-9592.2006.01991.x","article-title":"Airway management in two of newborns with Pierre Robin sequence: the use of disposable vs multiple use LMA for fiberoptic intubation","volume":"16","author":"J M Cain","year":"2006","journal-title":"Paediatr Anaesth"}],"container-title":["American Journal of 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