{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T16:28:12Z","timestamp":1772728092345,"version":"3.50.1"},"reference-count":28,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"03","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":57,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective:\u2003To assess the maternal blood levels of fatty acids (FAs) in pregnancies with fetal growth restriction (FGR).<\/jats:p><jats:p>\n          Methods:\u2003This prospective cross-sectional study included pregnant women with gestational age between 26 and 37\u2009+\u20096 weeks with FGR and appropriate for gestational age (AGA) fetuses. The levels of saturated, trans, monounsaturated, and polyunsaturated FAs were measured using centrifugation and liquid chromatography. The Student's t-test, Mann\u2013Whitney test, and general linear model, with gestational age and maternal weight as covariants, were used to compare FA levels and the FGR and AGA groups. The Chi-square was used to evaluate the association between groups and studied variables.<\/jats:p><jats:p>\n          Results:\u2003Maternal blood sample was collected from 64 pregnant women, being 24 FGR and 40 AGA. A weak positive correlation was found between the palmitoleic acid level and maternal weight (r\u2009=\u20090.285, p\u2009=\u20090.036). A weak negative correlation was found between the gamma-linoleic acid level and gestational age (r\u2009=\u2009\u2212\u20090.277, p\u2009=\u20090.026). The median of the elaidic acid level (2.3 vs. 4.7\u2009ng\/ml, p\u2009=\u20090.045) and gamma-linoleic acid (6.3 vs. 6.6\u2009ng\/ml, p\u2009=\u20090.024) was significantly lower in the FGR than the AGA group. The palmitoleic acid level was significantly higher in the FGR than AGA group (50.5 vs. 47.6\u2009ng\/ml, p\u2009=\u20090.033).<\/jats:p><jats:p>\n          Conclusion:\u2003Pregnant women with FGR had lower elaidic acid and gamma-linoleic acid levels and higher palmitoleic acid levels than AGA fetuses.<\/jats:p>","DOI":"10.1055\/s-0043-1768455","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T22:50:18Z","timestamp":1682635818000},"page":"127-133","source":"Crossref","is-referenced-by-count":3,"title":["Maternal Blood Fatty Acid Levels in Fetal Growth Restriction"],"prefix":"10.61622","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9704-2263","authenticated-orcid":false,"given":"Raquel Margiotte","family":"Grohmann","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine\u2013Federal University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7734-523X","authenticated-orcid":false,"given":"Vivian Macedo Gomes","family":"Mar\u00e7al","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine\u2013Federal University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"},{"name":"Department of Obstetrics and Gynecology, Medical Science College of Santos, Santos, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4951-8946","authenticated-orcid":false,"given":"Isabela C\u00e9sar","family":"Corazza","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine\u2013Federal University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1655-3609","authenticated-orcid":false,"given":"Alberto Borges","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Federal University of Tri\u00e2ngulo Mineiro, Uberaba, MG, Brazil"},{"name":"Gynecology and Obstetrics Service, M\u00e1rio Palm\u00e9rio University Hospital, University of Uberaba, Uberaba, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-2532","authenticated-orcid":false,"given":"Edward Araujo","family":"J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine\u2013Federal University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6196-7712","authenticated-orcid":false,"given":"Luciano Marcondes Machado","family":"Nardozza","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine\u2013Federal University of S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"issue":"24","key":"ref1","doi-asserted-by":"publisher","first-page":"3977","DOI":"10.3109\/14767058.2016.1152249","article-title":"Intrauterine growth restriction - part 1","volume":"29","author":"D Sharma","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"05","key":"ref2","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1007\/s00404-017-4341-9","article-title":"Fetal growth restriction: current knowledge","volume":"295","author":"L M Nardozza","year":"2017","journal-title":"Arch Gynecol Obstet"},{"issue":"05","key":"ref3","doi-asserted-by":"publisher","first-page":"R143","DOI":"10.1530\/REP-13-0376","article-title":"Maternal dietary omega-3 fatty acids and placental function","volume":"147","author":"M L 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