{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T16:01:57Z","timestamp":1765382517607,"version":"3.37.3"},"reference-count":51,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003The etiology of oral candidiasis (OC) was Candida albicans, C. krusei, C. dubliniensis, C. tropicalis that are frequently found in human immunodeficiency virus\/ acquired immunodeficiency syndrome (HIV\/AIDS) patients. Marine ascomycetes (MA) have been widely reported as an important producer of various antibiotic compounds. However, there is limited study of antifungal compounds from MA against Candida species. The aim of this study was to investigate the antifungal susceptibility of MA against Candida spp. isolates from OC HIV\/AIDS patient.<\/jats:p><jats:p>\n          Materials and Methods\u2003Trichoderma sp. is a sponge-associated fungus collected from Karimunjawa National Park, Central Java, Indonesia. The validation of C. albicans, C. krusei, C. dubliniensis, C. tropicalis. was done by ChromAgar. This study was true experimental with post-test only control group design; the sample was four replications for each group. Nystatin administration (K +), the golden standard antifungal drug, was used. The minimum fungicidal concentration (MFC), minimum inhibitory concentration (MIC), and diffusion zone methods were done. Analysis of variance difference test, and post-hoc Tukey's honest significant different were done to analyze the significant different between groups (p \u2264 0.05).<\/jats:p><jats:p>\n          Results\u2003The MFC and MIC of MA against C. albicans, C. krusei, C. dubliniensis, and C. tropicalis were found at 12.5%. In addition, the greatest diffusion zone of MA against C. albicans, C. krusei, C. dubliniensis, and C. tropicalis was found at 12.5%. There is no appreciable difference in antifungal activity between K + and 12.5% of MA extract (p \u2265 0.05).<\/jats:p><jats:p>\n          Conclusion\u2003Concentration of 12.5% MA extract has antifungal susceptibility against Candida spp. isolates from OC HIV\/AIDS patient.<\/jats:p>","DOI":"10.1055\/s-0043-1768466","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:10:32Z","timestamp":1708647032000},"page":"624-631","source":"Crossref","is-referenced-by-count":1,"title":["Marine Ascomycetes Extract Antifungal Susceptibility against Candida spp. Isolates from Oral Candidiasis HIV\/AIDS Patient: An In Vitro Study"],"prefix":"10.1055","volume":"18","author":[{"given":"Alexander Patera","family":"Nugraha","sequence":"additional","affiliation":[{"name":"Department of Orthodontic, Faculty of Dental Medicine - Universitas Airlangga, Surabaya, Indonesia"},{"name":"Immunology Study Programme, Postgraduate School, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mada Triandala","family":"Sibero","sequence":"additional","affiliation":[{"name":"Department of Marine Science, Fac. of Fisheries and Marine Science, Diponegoro University, Semarang, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kindi","family":"Farabi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6052-2287","authenticated-orcid":false,"given":"Meircurius Dwi Condro","family":"Surboyo","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Faculty of Dental Medicine - Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diah Savitri","family":"Ernawati","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Faculty of Dental Medicine - Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tengku Natasha Eleena binti Tengku","family":"Ahmad Noor","sequence":"additional","affiliation":[{"name":"Membership of Faculty of Dental Surgery, Royal Collage of Surgeon, Edinburgh University, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"issue":"01","key":"ref1","first-page":"81","article-title":"Prevalence of Candida species in oral candidiasis and correlation with CD4+ count in HIV\/AIDS patients at Surabaya, Indonesia","volume":"11","author":"A P Nugraha","year":"2018","journal-title":"J Int Dent Med Res"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"272","DOI":"10.5114\/hivar.2018.80259","article-title":"Oral 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