{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:35:14Z","timestamp":1791956114113,"version":"4.3.4"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Asian J Neurosurg"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003The choice of intraoperative fluid in neurosurgical patients is important as we need to maintain adequate cerebral perfusion and oxygenation and also avoid cerebral edema. Normal saline (NS) is commonly used in neurosurgeries, but it leads to hyperchloremic metabolic acidosis, which may result in coagulopathy. Balanced crystalloid with physiochemical composition akin to that of plasma has favorable effects on metabolic profile and may avoid the problems associated with NS. Against this background, the present study aimed to compare the effects of NS versus PlasmaLyte (PL) on coagulation profile in patients undergoing neurosurgical procedures.<\/jats:p><jats:p>\n          Methods\u2003This prospective, randomized, double-blinded study was conducted in 100 adult patients scheduled to undergo various neurosurgical procedures. Patients were randomly allocated in two groups of 50 each to receive either NS or PL intraoperatively and postoperatively till 4\u2009hours after the surgery. Hemoglobin, hematocrit, coagulation profile (PT, PTT, and INR), serum chloride, pH, blood urea, and serum creatinine were measured prior to induction (baseline) and 4\u2009hours after completion of surgery.<\/jats:p><jats:p>\n          Results\u2003Demographic characteristics were statistically similar between the two groups. Coagulation profile parameters were comparable between the two groups at baseline as well as 4\u2009hours after surgery. pH was significantly lower in the NS group as compared to the PL group at 4\u2009hours after surgery. Postoperatively blood urea, serum creatinine, and serum chloride levels were significantly raised in the NS group as compared to the PL group. Hemoglobin and hematocrit values were similar between the two groups.<\/jats:p><jats:p>\n          Conclusion\u2003Coagulation profile parameters were normal and statistically similar with intraoperative infusion of NS versus PL in patients undergoing neurosurgical procedures. However, use of PL was associated with a better acid\u2013base and renal profile in these patients.<\/jats:p>","DOI":"10.1055\/s-0043-1768598","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T23:27:20Z","timestamp":1686180440000},"page":"301-305","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Normal Saline versus PlasmaLyte on Coagulation and Metabolic Status in Patients Undergoing Neurosurgical Procedures"],"prefix":"10.1055","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8179-8442","authenticated-orcid":false,"given":"Vandna","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akanksha","family":"Khatri","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Bala","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibhuti","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Jindal","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/SLA.0b013e318295feba","article-title":"Saline versus Plasma-Lyte A in initial resuscitation of trauma patients: a randomized trial","volume":"259","author":"J BL Young","year":"2014","journal-title":"Ann Surg"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.23736\/S0390-5616.16.03221-5","article-title":"Normal saline versus balanced-salt solution as intravenous fluid therapy during neurosurgery: effects on acid-base balance and electrolytes","volume":"61","author":"M Hafizah","year":"2017","journal-title":"J Neurosurg Sci"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.4103\/0028-3886.241347","article-title":"Comparison of normal saline and balanced crystalloid (plasmalyte) in patients undergoing elective craniotomy for supratentorial brain tumors: a randomized controlled trial","volume":"66","author":"A Dey","year":"2018","journal-title":"Neurol India"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ijsu.2015.06.065","article-title":"The effect of 0.9% saline versus plasmalyte on coagulation in patients undergoing lumbar spinal surgery; a randomized controlled trial","volume":"20","author":"J W Song","year":"2015","journal-title":"Int J Surg"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1097\/00000542-200312000-00028","article-title":"Current transfusion practices of members of the American Society of Anesthesiologists: a survey","volume":"99","author":"G A Nuttall","year":"2003","journal-title":"Anesthesiology"},{"issue":"04","key":"ref6","first-page":"303","article-title":"Adverse effects of crystalloid and colloid fluids","volume":"49","author":"R G Hahn","year":"2017","journal-title":"Anaesthesiol Intensive Ther"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"364","DOI":"10.4097\/kjae.2015.68.4.364","article-title":"Changes in blood coagulation after colloid administration in patients undergoing total hip arthroplasty: comparison between pentastarch and tetrastarches, a randomized trial","volume":"68","author":"H J Shin","year":"2015","journal-title":"Korean J Anesthesiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1007\/BF03022250","article-title":"The effects of colloid solutions on hemostasis","volume":"53","author":"P Van der Linden","year":"2006","journal-title":"Can J Anaesth"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1053\/jcan.2002.125146","article-title":"A prospective, randomized comparison of thromboelastographic coagulation profile in patients receiving lactated Ringer's solution, 6% hetastarch in a balanced-saline vehicle, or 6% hetastarch in saline during major surgery","volume":"16","author":"G Martin","year":"2002","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/bja\/aen148","article-title":"Physiological effects of hyperchloraemia and acidosis","volume":"101","author":"J M Handy","year":"2008","journal-title":"Br J Anaesth"}],"container-title":["Asian Journal of Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1768598.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T23:29:10Z","timestamp":1688081350000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1768598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":10,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2023,6,29]]},"published-print":{"date-parts":[[2023,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1768598","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1793-5482","2248-9614"],"issn-type":[{"value":"1793-5482","type":"print"},{"value":"2248-9614","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]}}}