{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T16:55:04Z","timestamp":1740156904304,"version":"3.37.3"},"reference-count":22,"publisher":"Scientific Scholar","issue":"04","license":[{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003Pemphigus, a group of autoimmune bullous diseases, can be fatal, resulting from overwhelming opportunistic infection of lesions secondary to cutaneous bacterial infections. This study aimed to look into the cutaneous bacterial infection profile of pemphigus patients as timely identification and appropriate treatment can play a major role in reducing mortality.<\/jats:p><jats:p>\n          Materials and Methods\u2003Pus samples\/swabs received from patients with pemphigus over a 2-year period from July 2018 to June 2020 were subjected to standard microbiological culture techniques and susceptibility testing. The frequency of isolation and susceptibility profile of the different bacterial pathogens toward various antimicrobial agents were interpreted and analyzed as per the Clinical and Laboratory Standards Institute's guidelines.<\/jats:p><jats:p>\n          Results\u2003Samples from 315 patients were received during the study period comprising of 203 (64.4%) males and 112 (35.5%) females. Of 211 samples which were culture-positive, a total of 245 bacterial isolates were obtained, comprising of 158 Gram-positive cocci and 87 Gram-negative bacilli. Staphylococcus aureus (138, 56.3%) was the most common isolate followed by Pseudomonas aeruginosa (41, 16.7%) and Escherichia coli (16, 6.5%). Methicillin resistance was observed in 24.6% Staphylococcus aureus isolates and carbapenem resistance in 9.5 to 14.6% Gram-negative bacilli.<\/jats:p><jats:p>\n          Conclusions\u2003Study findings emphasize the need for continuous monitoring of cutaneous pemphigus lesions for appropriate choice of antimicrobial therapy.<\/jats:p>","DOI":"10.1055\/s-0043-1768635","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T23:14:50Z","timestamp":1683328490000},"page":"616-620","source":"Crossref","is-referenced-by-count":0,"title":["Profile of Cutaneous Bacterial Flora in Pemphigus Patients"],"prefix":"10.25259","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6706-0660","authenticated-orcid":false,"given":"Srujana","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Microbiology, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swarnatrisha","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Microbiology, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shehnaz","family":"Firdaus","sequence":"additional","affiliation":[{"name":"Department of Microbiology, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandra Sekhar","family":"Sirka","sequence":"additional","affiliation":[{"name":"Department of Dermatology, All India Institute of Medical Sciences Bhubaneswar, Bhubaneswar, Odisha, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"10894","published-online":{"date-parts":[[2023,5,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S0190-9622(88)70128-0","article-title":"Pemphigus","volume":"18","author":"N Korman","year":"1988","journal-title":"J Am Acad Dermatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.3389\/fimmu.2019.01418","article-title":"Pemphigus: current and future therapeutic strategies","volume":"10","author":"D Didona","year":"2019","journal-title":"Front Immunol"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"439","DOI":"10.4103\/0378-6323.82396","article-title":"Pemphigus in India","volume":"77","author":"A J Kanwar","year":"2011","journal-title":"Indian J Dermatol Venereol Leprol"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12941-020-00388-6","article-title":"Features and associated factors of bacterial skin infections in hospitalized patients with pemphigus: a single-center retrospective study","volume":"19","author":"F Li","year":"2020","journal-title":"Ann Clin Microbiol Antimicrob"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"774","DOI":"10.4103\/0378-6323.102392","article-title":"Etiology of pyrexia in pemphigus patients: a dermatologist's enigma","volume":"78","author":"H H Qadim","year":"2012","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"ref6","first-page":"131","volume-title":"Tests for the identification of bacteria","author":"J G Collee","year":"1996","edition":"14th ed."},{"key":"ref7","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing","author":"CLSI","year":"2020","edition":"30th ed."},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1111\/jdv.14961","article-title":"Association of serious infections with pemphigus and pemphigoid: analysis of the Nationwide Inpatient Sample","volume":"32","author":"Z Ren","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref10","first-page":"1563","article-title":"Predisposition to infection in patients with pemphigus. Retrospective study of 141 cases [in French]","volume":"36","author":"F Z Belgnaoui","year":"2007","journal-title":"Presse Med"},{"key":"ref11","first-page":"834295","article-title":"Pemphigus vulgaris and infections: a retrospective study on 155 patients","volume":"2013","author":"N Esmaili","year":"2013","journal-title":"Autoimmune Dis"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4103\/ijd.IJD_152_17","article-title":"Cutaneous bacteriological profile in patients with pemphigus","volume":"63","author":"K C Kiran","year":"2018","journal-title":"Indian J Dermatol"},{"issue":"02","key":"ref13","first-page":"89","article-title":"Bacterial culture and sensitivity in pemphigus","volume":"63","author":"R B Solanki","year":"1997","journal-title":"Indian J Dermatol Venereol Leprol"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0190-9622(82)70111-2","article-title":"Death in 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