{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T13:05:47Z","timestamp":1762088747744,"version":"build-2065373602"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"06","license":[{"start":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T00:00:00Z","timestamp":1687910400000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Sleep disorders have a negative impact on health, being associated with neurocognitive problems, cardiovascular diseases and obesity, influencing children's development and learning.<\/jats:p><jats:p>\n          Objective\u2003To assess the sleep pattern of people with Down syndrome (DS) and correlate changes with functionality and behavior.<\/jats:p><jats:p>\n          Methods\u2003A cross-sectional study was conducted to evaluate the sleep pattern in adults with DS\u2009&gt;\u200918 years old. Twenty-two participants were assessed using the Pittsburgh Sleep Quality Index, the Functional Independence Measure and the Strengths and Difficulties Questionnaire, and the 11 who presented indications of disorders by the screening questionnaires were referred to polysomnography. Statistical tests were performed using a significance level of 5%, including sample normality tests and correlation tests (sleep and functionality).<\/jats:p><jats:p>\n          Results\u2003Impairment in sleep architecture was found due to an increase in the rate of awakenings in 100% of the participants, a decrease in the number of slow waves, and a high prevalence of sleep disordered breathing (SDB), with higher averages in the Apnea and Hypopnea Index (AHI) in the group. There was a negative correlation between sleep quality and global functionality (p\u2009=\u20090.011) and the motor (p\u2009=\u20090.074), cognitive (p\u2009=\u20090.010), and personal care (p\u2009=\u20090.072) dimensions in the group. Global and hyperactivity behavior changes were related to worse sleep quality (p\u2009=\u20090.072; p\u2009=\u20090.015, respectively).<\/jats:p><jats:p>\n          Conclusion\u2003There is an impairment in the sleep quality of adults with DS, with an increase in the rate of awakenings, a decrease in the number of slow waves, and a high prevalence of SDB affecting this population in the functional and behavioral aspects.<\/jats:p>","DOI":"10.1055\/s-0043-1768670","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T22:52:42Z","timestamp":1687992762000},"page":"544-550","source":"Crossref","is-referenced-by-count":2,"title":["Sleep assessment in adults with Down syndrome: correlation between functionality and polysomnographic findings"],"prefix":"10.1055","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3242-0838","authenticated-orcid":false,"given":"Marilia Rezende","family":"Callegari","sequence":"additional","affiliation":[{"name":"Universidade Presbiteriana Mackenzie, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2560-4428","authenticated-orcid":false,"given":"Kelly Brito","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Universidade Presbiteriana Mackenzie, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3075-5407","authenticated-orcid":false,"given":"Barbara Valente","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Presbiteriana Mackenzie, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8497-0407","authenticated-orcid":false,"given":"Ana Rita Avelino","family":"Amorim","sequence":"additional","affiliation":[{"name":"Universidade Presbiteriana Mackenzie, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9874-4507","authenticated-orcid":false,"given":"Raquel","family":"Cymrot","sequence":"additional","affiliation":[{"name":"Universidade Presbiteriana Mackenzie, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5437-891X","authenticated-orcid":false,"given":"Silvana Maria","family":"Blascovi-Assis","sequence":"additional","affiliation":[{"name":"Universidade Presbiteriana Mackenzie, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, S\u00e3o Paulo SP, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,6,28]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/ajmg.a.38043","article-title":"Down syndrome in diverse populations","volume":"173","author":"P Kruszka","year":"2017","journal-title":"Am J Med Genet A"},{"issue":"02","key":"ref2","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/ajmg.c.31439","article-title":"Down syndrome: Cognitive and behavioral functioning across the lifespan","volume":"169","author":"J Grieco","year":"2015","journal-title":"Am J Med Genet C Semin Med Genet"},{"issue":"05","key":"ref3","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.smrv.2011.10.003","article-title":"Sleep measurement and monitoring in children with Down syndrome: a review of the literature, 1960-2010","volume":"16","author":"S S Churchill","year":"2012","journal-title":"Sleep Med Rev"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ijporl.2015.12.014","article-title":"Verhulst s, Wojciechowski M, Van de Heyning P, Boudewyns A. 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