{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:15:14Z","timestamp":1787004914001,"version":"build-2736575974"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":38,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background\u2003Evidence indicates a strong link between Zika virus (ZikV) and neurological complications. Acute myelitis, optic neuritis, polyneuropathy, and encephalomyelitis that mimic inflammatory idiopathic demyelination disorders (IIDD) after ZikV infection have been reported in Brazil.<\/jats:p>\n                  <jats:p>Objective\u2003The present study aims to investigate the possible occurrence of molecular mimicry between ZikV antigens and Multiple Sclerosis (MS) autoantigens, the most frequent IIDD of the central nervous system (CNS).<\/jats:p>\n                  <jats:p>Methods\u2003A retrospective cohort study with 305 patients admitted due to suspected arbovirus infection in Rio de Janeiro was performed, all subjects were submitted to neurological examination, and a biological sample was collected for serologic and molecular diagnostic. Bioinformatics tools were used to analyze the peptides shared between ZikV antigens and MS autoantigens.<\/jats:p>\n                  <jats:p>Results\u2003Of 305 patients, twenty-six were positive for ZikV and 4 presented IDD patterns found in MS cases. Sequence homology comparisons by bioinformatics approach between NS5 ZikV and PLP MS protein revealed a homology of 5\/6 consecutive amino acids (CSSVPV\/CSAVPV) with 83% identity, deducing a molecular mimicry. Analysis of the 3D structures revealed a similar conformation with alpha helix presentation.<\/jats:p>\n                  <jats:p>Conclusions\u2003Molecular mimicry between NS5 Zika virus antigen and PLP MS autoantigens emerge as a possible mechanism for IDD spectrum in genetically susceptible individuals.<\/jats:p>","DOI":"10.1055\/s-0043-1768698","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T03:07:49Z","timestamp":1683688069000},"page":"357-368","source":"Crossref","is-referenced-by-count":9,"title":["Molecular mimicry between Zika virus and central nervous system inflammatory demyelinating disorders: the role of NS5 Zika virus epitope and PLP autoantigens"],"prefix":"10.1055","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8851-7845","authenticated-orcid":false,"given":"Laise Carolina","family":"Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Neurologia, Laborat\u00f3rio de Neuroci\u00eancias Translacional, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5201-0927","authenticated-orcid":false,"given":"Fabr\u00edcia Lima","family":"Fontes-Dantas","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Neurologia, Laborat\u00f3rio de Neuroci\u00eancias Translacional, Rio de Janeiro RJ, Brazil."},{"name":"Universidade do Estado do Rio de Janeiro, Departamento de Farmacologia e Psicobiologia, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3434-1589","authenticated-orcid":false,"given":"Diogo Gomes","family":"Garcia","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Neurologia, Laborat\u00f3rio de Neuroci\u00eancias Translacional, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6233-1428","authenticated-orcid":false,"given":"Amanda Dutra","family":"de Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Neurologia, Laborat\u00f3rio de Neuroci\u00eancias Translacional, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2621-3138","authenticated-orcid":false,"given":"Jo\u00e3o Paulo","family":"da Costa Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Neurologia, Laborat\u00f3rio de Neuroci\u00eancias Translacional, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1837-4401","authenticated-orcid":false,"given":"Cl\u00e1udia Cec\u00edlia da Silva","family":"R\u00eago","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Neurologia, Laborat\u00f3rio de Neuroci\u00eancias Translacional, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5355-0538","authenticated-orcid":false,"given":"Elielson Veloso","family":"da Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Neurologia, Laborat\u00f3rio de Neuroci\u00eancias Translacional, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3516-485X","authenticated-orcid":false,"given":"Osvaldo Jos\u00e9 Moreira","family":"do Nascimento","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Hospital Universit\u00e1rio Ant\u00f4nio Pedro, Departamento de Neurologia, Niter\u00f3i RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3782-8624","authenticated-orcid":false,"given":"Fernanda Cristina Rueda","family":"Lopes","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Hospital Universit\u00e1rio Ant\u00f4nio Pedro, Departamento de Radiologia, Niter\u00f3i RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7660-7058","authenticated-orcid":false,"given":"Alice Laschuk","family":"Herlinger","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Hospital Universit\u00e1rio Ant\u00f4nio Pedro, Departamento de Radiologia, Niter\u00f3i RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5180-3717","authenticated-orcid":false,"given":"Renato Santana","family":"de Aguiar","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Hospital Universit\u00e1rio Ant\u00f4nio Pedro, Departamento de Radiologia, Niter\u00f3i RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1970-8936","authenticated-orcid":false,"given":"Orlando","family":"da Costa Ferreira Junior","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Instituto de Biologia, Departamento de Gen\u00e9tica, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3242-9007","authenticated-orcid":false,"given":"Fernando Faria Andrade","family":"Figueira","sequence":"additional","affiliation":[{"name":"Hospital S\u00e3o Francisco na Provid\u00eancia de Deus, Departamento de Neurologia, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2412-8239","authenticated-orcid":false,"given":"Jorge Paes Barreto Marcondes","family":"de Souza","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Neurologia, Laborat\u00f3rio de Neuroci\u00eancias Translacional, Rio de Janeiro RJ, Brazil."},{"name":"Universidade Federal do Rio de Janeiro, Hospital Universit\u00e1rio Clementino Fraga Filho, Departamento de Neurocirurgia, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1684-3830","authenticated-orcid":false,"given":"Joelma Freire","family":"De Mesquita","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro, Departamento de Gen\u00e9tica e Biologia Molecular, Grupo de Bioinform\u00e1tica e Biologia Computacional, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1538-6730","authenticated-orcid":false,"given":"Soniza Vieira","family":"Alves-Leon","sequence":"additional","affiliation":[{"name":"Universidade Federal do Estado do Rio de Janeiro, Programa de P\u00f3s-Gradua\u00e7\u00e3o em Neurologia, Laborat\u00f3rio de Neuroci\u00eancias Translacional, Rio de Janeiro RJ, Brazil."},{"name":"Universidade Federal do Rio de Janeiro, Hospital Universit\u00e1rio Clementino Fraga Filho, Centro de Refer\u00eancia e Pesquisa em Esclerose M\u00faltipla e Outras Doen\u00e7as Desmielinizantes Inflamat\u00f3rias Idiop\u00e1ticas do SNC, Rio de Janeiro RJ, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"issue":"04","key":"ref2","doi-asserted-by":"publisher","first-page":"ofw203","DOI":"10.1093\/ofid\/ofw203","article-title":"Zika virus causing encephalomyelitis associated with immunoactivation","volume":"3","author":"R M Galliez","year":"2016","journal-title":"Open Forum Infect Dis"},{"issue":"10","key":"ref3","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika Virus Associated with Microcephaly","volume":"374","author":"J Mlakar","year":"2016","journal-title":"N Engl J Med"},{"issue":"10","key":"ref4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/v10100530","article-title":"Ocular Manifestations of Emerging Flaviviruses and the Blood-Retinal Barrier","volume":"10","author":"S Singh","year":"2018","journal-title":"Viruses"},{"issue":"03","key":"ref6","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1177\/1352458518781992","article-title":"Zika virus found in brain tissue of a multiple sclerosis patient undergoing an acute disseminated encephalomyelitis-like episode","volume":"25","author":"S V Alves-Leon","year":"2019","journal-title":"Mult Scler"},{"issue":"426","key":"ref7","doi-asserted-by":"publisher","first-page":"eaao7090","DOI":"10.1126\/scitranslmed.aao7090","article-title":"Zika virus-related neurotropic flaviviruses infect human placental explants and cause fetal demise in mice","volume":"10","author":"D J Platt","year":"2018","journal-title":"Sci Transl Med"},{"issue":"11","key":"ref8","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1089\/jir.2017.0106","article-title":"T Cell Immunity to Zika and Dengue Viral Infections","volume":"37","author":"J Wen","year":"2017","journal-title":"J Interferon Cytokine Res"},{"issue":"08","key":"ref10","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.autrev.2016.03.020","article-title":"Zika virus and autoimmunity: From microcephaly to Guillain-Barr\u00e9 syndrome, and beyond","volume":"15","author":"G Lucchese","year":"2016","journal-title":"Autoimmun Rev"},{"issue":"12","key":"ref11","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1007\/s11604-016-0588-5","article-title":"Neuroimaging findings of Zika virus infection: a review article","volume":"34","author":"M Zare Mehrjardi","year":"2016","journal-title":"Jpn J Radiol"},{"issue":"06","key":"ref12","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.4269\/ajtmh.17-0938","article-title":"Case Report: Acute Transverse Myelitis after Zika Virus Infection","volume":"99","author":"V C Neri","year":"2018","journal-title":"Am J Trop Med Hyg"},{"issue":"02","key":"ref14","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S1474-4422(12)70309-5","article-title":"Epigenetic mechanisms in multiple sclerosis: implications for pathogenesis and treatment","volume":"12","author":"J L Huynh","year":"2013","journal-title":"Lancet Neurol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/B978-0-444-52001-2.00008-X","article-title":"The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment","volume":"122","author":"A P Robinson","year":"2014","journal-title":"Handb Clin Neurol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.1212\/WNL.0000000000003029","article-title":"Environmental and genetic factors in pediatric inflammatory demyelinating diseases","volume":"87","author":"E Waubant","year":"2016","journal-title":"Neurology"},{"issue":"13","key":"ref17","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1096\/fasebj.12.13.1255","article-title":"Molecular mimicry and immune-mediated diseases","volume":"12","author":"M B Oldstone","year":"1998","journal-title":"FASEB J"},{"issue":"01","key":"ref18","doi-asserted-by":"publisher","first-page":"e0005238","DOI":"10.1371\/journal.pntd.0005238","article-title":"Molecular Mimicry between Chikungunya Virus and Host Components: A Possible Mechanism for the Arthritic Manifestations","volume":"11","author":"V Reddy","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"issue":"05","key":"ref19","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1258\/ebm.2011.010339","article-title":"Molecular mimicry between virus and host and its implications for dengue disease pathogenesis","volume":"236","author":"Y-S Lin","year":"2011","journal-title":"Exp Biol Med (Maywood)"},{"issue":"06","key":"ref21","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.tibs.2017.02.009","article-title":"Structural Biology of the Zika Virus","volume":"42","author":"Y Shi","year":"2017","journal-title":"Trends Biochem Sci"},{"issue":"10","key":"ref22","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1016\/j.amjmed.2016.04.034","article-title":"The Clinical Spectrum of Zika Virus in Returning Travelers","volume":"129","author":"E Meltzer","year":"2016","journal-title":"Am J Med"},{"issue":"07","key":"ref23","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1001\/jamaneurol.2016.0800","article-title":"Zika virus as an emerging global pathogen: Neurological complications of zika virus","volume":"73","author":"J D Beckham","year":"2016","journal-title":"JAMA Neurol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jns.2018.10.032","article-title":"Concurrent Guillain-Barr\u00e9 syndrome, transverse myelitis and encephalitis post-Zika: A case report and review of the pathogenic role of multiple arboviral immunity","volume":"396","author":"G C Rom\u00e1n","year":"2019","journal-title":"J Neurol Sci"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"37313","DOI":"10.1038\/srep37313","article-title":"Towards peptide vaccines against Zika virus: Immunoinformatics combined with molecular dynamics simulations to predict antigenic epitopes of Zika viral proteins","volume":"6","author":"M U Mirza","year":"2016","journal-title":"Sci Rep"},{"issue":"07","key":"ref26","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1093\/nar\/gki524","article-title":"TM-align: a protein structure alignment algorithm based on the TM-score","volume":"33","author":"Y Zhang","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"14762","DOI":"10.1038\/ncomms14762","article-title":"Structure and function of the Zika virus full-length NS5 protein","volume":"8","author":"B Zhao","year":"2017","journal-title":"Nat Commun"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"151427","DOI":"10.1155\/2013\/151427","article-title":"Autoimmune T-cell reactivity to myelin proteolipids and glycolipids in multiple sclerosis","volume":"2013","author":"J M Greer","year":"2013","journal-title":"Mult Scler Int"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"14763","DOI":"10.1038\/ncomms14763","article-title":"The structure of Zika virus NS5 reveals a conserved domain conformation","volume":"8","author":"B Wang","year":"2017","journal-title":"Nat Commun"},{"issue":"01","key":"ref34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00401-016-1653-y","article-title":"An updated histological classification system for multiple sclerosis lesions","volume":"133","author":"T Kuhlmann","year":"2017","journal-title":"Acta Neuropathol"},{"issue":"06","key":"ref35","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s00251-008-0295-1","article-title":"The immunogenetics of multiple sclerosis","volume":"60","author":"A Svejgaard","year":"2008","journal-title":"Immunogenetics"},{"issue":"05","key":"ref36","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1111\/j.1600-0404.2006.00750.x","article-title":"Ethnicity-dependent association of HLA DRB1-DQA1-DQB1 alleles in Brazilian multiple sclerosis patients","volume":"115","author":"S V Alves-Leon","year":"2007","journal-title":"Acta Neurol Scand"},{"issue":"01","key":"ref37","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1002\/eji.200324597","article-title":"Identification of T cell epitopes on human proteolipid protein and induction of experimental autoimmune encephalomyelitis in HLA class II-transgenic mice","volume":"34","author":"A K Mangalam","year":"2004","journal-title":"Eur J Immunol"},{"issue":"05","key":"ref38","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1002\/eji.200324354","article-title":"Myelin oligodendrocyte glycoprotein-35-55 peptide induces severe chronic experimental autoimmune encephalomyelitis in HLA-DR2-transgenic mice","volume":"34","author":"C Rich","year":"2004","journal-title":"Eur J Immunol"},{"issue":"01","key":"ref39","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1742-2094-9-29","article-title":"DQB1*0602 rather than DRB1*1501 confers susceptibility to multiple sclerosis-like disease induced by proteolipid protein (PLP)","volume":"9","author":"N Kaushansky","year":"2012","journal-title":"J Neuroinflammation"},{"issue":"06","key":"ref40","doi-asserted-by":"publisher","first-page":"3893","DOI":"10.4049\/jimmunol.172.6.3893","article-title":"Expansion and functional relevance of high-avidity myelin-specific CD4+ T cells in multiple sclerosis","volume":"172","author":"B Bielekova","year":"2004","journal-title":"J Immunol"},{"issue":"09","key":"ref41","doi-asserted-by":"crossref","first-page":"6402","DOI":"10.4049\/jimmunol.180.9.6402","article-title":"Correlation of blood T cell and antibody reactivity to myelin proteins with HLA type and lesion localization in multiple sclerosis","volume":"180","author":"J M Greer","year":"2008","journal-title":"J Immunol"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1768698.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T03:08:29Z","timestamp":1683688109000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1768698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":32,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2023,5,9]]},"published-print":{"date-parts":[[2023,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1768698","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0004-282X","1678-4227"],"issn-type":[{"value":"0004-282X","type":"print"},{"value":"1678-4227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4]]}}}