{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:51:06Z","timestamp":1780487466063,"version":"3.54.1"},"reference-count":10,"publisher":"Scientific Scholar","issue":"04","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Lab Physicians"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus-associated pneumonia and acute respiratory distress syndrome (ARDS) were often associated with hyperinflammation and elevation of several serum inflammatory markers but usually less than what is observed in non-coronavirus disease (COVID) ARDS. Elevated inflammatory markers such as C-reactive protein, interleukin (IL)-6, etc., are associated with severe infection. This study identified subphenotypes of COVID-19 ARDS patients by latent profile analysis in a cohort of Indian patients.<\/jats:p><jats:p>\n          Methods\u2003Data of n\u2009=\u2009233 adult Indian patients with laboratory-confirmed SARS-CoV-2 infection admitted to a tertiary care teaching hospital were analyzed in this retrospective study. Only patients with acute respiratory failure (defined by partial pressure of oxygen\/fraction of inspired oxygen ratio\u2009&lt;\u2009200\u2009mm Hg) and chest X-ray showing bilateral infiltrates were included.<\/jats:p><jats:p>\n          Results\u2003The patients' mean (standard deviation) age was 53.3 (14.9) years, and 62% were male. A two subphenotypic model was formulated based on the lowest Bayesian information criterion. Neutrophil-to-lymphocyte ratio and serum IL-6 were latent variables in that model (entropy 0.91). The second phenotype (hyperinflammatory) had lower platelet count (p\u2009=\u20090.02), higher serum creatinine (p\u2009=\u20090.004), higher C-reactive protein (p\u2009=\u20090.001), higher ferritin (p\u2009&lt;\u20090.001), and serum lactate dehydrogenase (p\u2009=\u20090.009). Age-adjusted hospital mortality (p\u2009=\u20090.007), duration of hospital stay (p\u2009&lt;\u20090.001), and duration of intensive care unit stay (p\u2009&lt;\u20090.001) were significantly higher in the second subphenotype.<\/jats:p><jats:p>\n          Conclusion\u2003Two distinct but overlapping subphenotypes were identified in SARS-CoV-2-associated respiratory failure. Hyperinflammatory subphenotype was associated with significantly poor short-term outcomes.<\/jats:p>","DOI":"10.1055\/s-0043-1768952","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T23:06:01Z","timestamp":1688425561000},"page":"558-561","source":"Crossref","is-referenced-by-count":5,"title":["Subphenotypes of SARS-CoV-2-Associated ARDS Overlap Each Other: A Retrospective Analysis"],"prefix":"10.25259","volume":"15","author":[{"given":"Parvathy R.","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine & Critical Care, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavitha","family":"Girish","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine & Critical Care, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gouri","family":"Mini","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine & Critical Care, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1420-6558","authenticated-orcid":false,"given":"Tazeen","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine & Critical Care, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damarla","family":"Haritha","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine & Critical Care, All India Institute of Medical Sciences, New Delhi, 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India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bikash R.","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine & Critical Care, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul K.","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology, Pain Medicine & Critical Care, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5550-663X","authenticated-orcid":false,"given":"Sudip K.","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Soneja","sequence":"additional","affiliation":[{"name":"Department of Medicine, 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