{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T12:12:33Z","timestamp":1742386353429,"version":"3.28.0"},"reference-count":87,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Herbal medicine has an important part in promoting and maintaining human health. One of them was grape seed extract (GSE). Various potentials of GSE in human health have been explored, and its potential for maintaining bone health is promising. Some initial research has provided evidence that the GSE was able to affect bone remodeling (bone resorption and bone formation). This scoping review analyzed and discussed all the reports on the effect of GSE on bone healing and bone remodeling in animals in the alveolar bone, jaw bone, and skeletal bone. The further purpose is to give an opportunity to research and development of supplementation of GSE for humans.<\/jats:p><jats:p>The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) 2020 guidelines were used to compose this scoping review through database on Scopus, PubMed, Science Direct, Web of Science, Embase, and manual search until December 2022. The inclusion criteria were a study that analyzed the effect of supplementation GSE on all bones.<\/jats:p><jats:p>All included study was in vivo study with supplementation of GSE. The supplementation of GSE affects the alveolar bone, jaw bones, and skeletal bone by promoting bone formation and inhibiting bone resorption by suppressing inflammation, apoptosis pathways, and osteoclastogenesis. It not only supports bone remodeling in bone inflammation, osteonecrosis, osteoporosis, and arthritis but also the GSE increases bone health by increasing the density and mineral deposition in trabecula and cortical bone.<\/jats:p><jats:p>The supplementation of GSE supports bone remodeling by interfering with the inflammation process and bone formation not only by preventing bone resorption but also by maintaining bone density.<\/jats:p>","DOI":"10.1055\/s-0043-1768975","type":"journal-article","created":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T23:06:08Z","timestamp":1686697568000},"page":"073-085","source":"Crossref","is-referenced-by-count":3,"title":["The Effect of Grape Seed Extract on the Alveolar, Jaw, and Skeletal Bone Remodeling: A Scoping Review"],"prefix":"10.1055","volume":"18","author":[{"given":"Erdiarti Dyah","family":"Wahyuningtyas","sequence":"additional","affiliation":[{"name":"Department of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ari","family":"Triwardhani","sequence":"additional","affiliation":[{"name":"Department of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I Gusti Aju Wahju","family":"Ardani","sequence":"additional","affiliation":[{"name":"Department of Orthodontic, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meircurius Dwi Condro","family":"Surboyo","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,6,13]]},"reference":[{"issue":"18","key":"ref1","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.3390\/foods11182755","article-title":"Bioactive compounds, health benefits and food applications of grape","volume":"11","author":"D D Zhou","year":"2022","journal-title":"Foods"},{"issue":"04","key":"ref2","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s13197-019-04113-w","article-title":"Grape seed extract: having a potential health benefits","volume":"57","author":"M Gupta","year":"2020","journal-title":"J Food Sci Technol"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.3390\/nu11102435","article-title":"Grape seeds proanthocyanidins: an overview of in vivo bioactivity in animal models","volume":"11","author":"C Rodr\u00edguez-P\u00e9rez","year":"2019","journal-title":"Nutrients"},{"issue":"03","key":"ref4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3390\/antiox6030071","article-title":"Phytochemical constituents, health benefits, and industrial applications of grape seeds: a mini-review","volume":"6","author":"Z F Ma","year":"2017","journal-title":"Antioxidants"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3390\/ijms18020376","article-title":"Cocoa and grape seed byproducts as a source of antioxidant and anti-inflammatory proanthocyanidins","volume":"18","author":"M L C\u00e1diz-Gurrea","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"22","key":"ref6","doi-asserted-by":"crossref","first-page":"5311","DOI":"10.3390\/molecules25225311","article-title":"Health effects of grape seed and skin extracts and their influence on biochemical markers","volume":"25","author":"L Sochorova","year":"2020","journal-title":"Molecules"},{"issue":"07","key":"ref7","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1021\/jf011066w","article-title":"90-day oral toxicity study of a grape seed extract (IH636) in rats","volume":"50","author":"A F Wren","year":"2002","journal-title":"J Agric Food Chem"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.foodres.2011.01.022","article-title":"Green tea and grape seed extracts \u2014 Potential applications in food safety and quality","volume":"44","author":"A VS Perumalla","year":"2011","journal-title":"Food Res Int"},{"issue":"01","key":"ref9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1177\/0260106019887890","article-title":"Prevention of dental caries by grape seed extract supplementation: a systematic review","volume":"26","author":"N M Delimont","year":"2020","journal-title":"Nutr Health"},{"issue":"08","key":"ref10","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.jdent.2014.05.006","article-title":"The preventive effect of grape seed extract on artificial enamel caries progression in a microbial biofilm-induced caries model","volume":"42","author":"W Zhao","year":"2014","journal-title":"J Dent"},{"issue":"01","key":"ref11","first-page":"301","article-title":"Salivary pellicle modification with grape-seed extract: in vitro study on the effect on bacterial adhesion and biofilm formation","volume":"19","author":"T S Carvalho","year":"2021","journal-title":"Oral Health Prev Dent"},{"issue":"01","key":"ref12","first-page":"35","article-title":"Antibacterial efficacy of the grape seed extract as an irrigant for root canal preparation","volume":"5","author":"F S D'aviz","year":"2020","journal-title":"Eur Endod J"},{"issue":"04","key":"ref13","doi-asserted-by":"crossref","first-page":"580","DOI":"10.25122\/jml-2020-0177","article-title":"Grape seed extract reduces the degree of atherosclerosis in ligature-induced periodontitis in rats - an experimental study","volume":"13","author":"T Dimitriu","year":"2020","journal-title":"J Med Life"},{"key":"ref14","first-page":"89","article-title":"Clinical efficacy of grape seed extract as an adjuvant to scaling and root planning in treatment of periodontal pockets","volume":"35","author":"M Das","year":"2021","journal-title":"J Biol Regul Homeost Agents"},{"issue":"04","key":"ref15","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1055\/s-0039-3401440","article-title":"Postorthodontic relapse prevention by administration of grape seed (Vitis vinifera) extract containing cyanide in rats","volume":"13","author":"A A Alhasyimi","year":"2019","journal-title":"Eur J Dent"},{"issue":"09","key":"ref16","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.3390\/cells9092073","article-title":"Osteoblast-osteoclast communication and bone homeostasis","volume":"9","author":"J M Kim","year":"2020","journal-title":"Cells"},{"issue":"14","key":"ref17","doi-asserted-by":"crossref","first-page":"5169","DOI":"10.3390\/ijms21145169","article-title":"Osteocyte-related cytokines regulate osteoclast formation and bone resorption","volume":"21","author":"H Kitaura","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"01","key":"ref18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41368-021-00125-5","article-title":"Biomechanical and biological responses of periodontium in orthodontic tooth movement: up-date in a new decade","volume":"13","author":"Y Li","year":"2021","journal-title":"Int J Oral Sci"},{"issue":"05","key":"ref19","first-page":"139","article-title":"Neural regulation of alveolar bone remodeling and periodontal ligament metabolism during orthodontic tooth movement in response to therapeutic loading","volume":"11","author":"M Zhang","year":"2022","journal-title":"J World Fed Orthod"},{"issue":"22","key":"ref20","doi-asserted-by":"crossref","first-page":"15002","DOI":"10.3390\/ijerph192215002","article-title":"Bone remodeling during orthodontic movement of lower incisors-narrative review","volume":"19","author":"E Kalina","year":"2022","journal-title":"Int J Environ Res Public Health"},{"issue":"02","key":"ref21","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3177\/jnsv.53.174","article-title":"Beneficial effects of grape seed extract on malondialdehyde-modified LDL","volume":"53","author":"A Sano","year":"2007","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"issue":"01","key":"ref22","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/jsfa.7079","article-title":"Antioxidant effects of proanthocyanidin-rich natural extracts from grape seed and cupuassu on gastrointestinal mucosa","volume":"96","author":"M Pinent","year":"2016","journal-title":"J Sci Food Agric"},{"issue":"06","key":"ref23","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3390\/antiox10060943","article-title":"Pre-treatment with grape seed extract reduces inflammatory response and oxidative stress induced by Helicobacter pylori infection in human gastric epithelial cells","volume":"10","author":"J M Silvan","year":"2021","journal-title":"Antioxidants"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"112253","DOI":"10.1016\/j.jep.2019.112253","article-title":"The effects of Vitis vinifera L. phenolic compounds on a blood-brain barrier culture model: expression of leptin receptors and protection against cytokine-induced damage","volume":"247","author":"A Ardid-Ruiz","year":"2020","journal-title":"J Ethnopharmacol"},{"issue":"09","key":"ref25","doi-asserted-by":"crossref","first-page":"4898","DOI":"10.1002\/ptr.7120","article-title":"Effects of grape products on inflammation and oxidative stress: a systematic review and meta-analysis of randomized controlled trials","volume":"35","author":"S S Ghalishourani","year":"2021","journal-title":"Phytother Res"},{"issue":"02","key":"ref26","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ptr.6518","article-title":"The effects of grape seed extract on glycemic control, serum lipoproteins, inflammation, and body weight: a systematic review and meta-analysis of randomized controlled trials","volume":"34","author":"O Asbaghi","year":"2020","journal-title":"Phytother Res"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","first-page":"e14469","DOI":"10.1111\/ijcp.14469","article-title":"The effect of grape seed extract supplementation on oxidative stress and inflammation: a systematic review and meta-analysis of controlled trials","volume":"75","author":"S Foshati","year":"2021","journal-title":"Int J Clin Pract"},{"issue":"01","key":"ref28","doi-asserted-by":"crossref","first-page":"8812","DOI":"10.1038\/s41598-020-65403-4","article-title":"Proanthocyanidin-rich grape seed extract improves bone loss, bone healing, and implant osseointegration in ovariectomized animals","volume":"10","author":"T Tenkumo","year":"2020","journal-title":"Sci Rep"},{"issue":"01","key":"ref29","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.bbrc.2018.12.125","article-title":"Proanthocyanidins inhibit osteoclast formation and function by inhibiting the NF-\u03baB and JNK signaling pathways during osteoporosis treatment","volume":"509","author":"W Zhu","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"issue":"05","key":"ref30","first-page":"722","article-title":"Effects of grape seed proanthocyanidins extracts on AGEs and expression of bone morphogenetic protein-7 in diabetic rats","volume":"21","author":"X Li","year":"2008","journal-title":"J Nephrol"},{"issue":"01","key":"ref31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1600-0722.2004.00176.x","article-title":"Grape seed proanthocyanidins extract promotes bone formation in rat's mandibular condyle","volume":"113","author":"M Ishikawa","year":"2005","journal-title":"Eur J Oral Sci"},{"issue":"01","key":"ref32","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1186\/s13018-020-01932-y","article-title":"The protective effects of grape seed oil on induced osteoarthritis of the knee in male rat models","volume":"15","author":"N Tanideh","year":"2020","journal-title":"J Orthop Surg Res"},{"issue":"06","key":"ref33","first-page":"799","article-title":"Literature search strategies in dental education and research","volume":"16","author":"Z Khurshid","year":"2021","journal-title":"J Taibah Univ Med Sci"},{"issue":"01","key":"ref34","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4274\/meandros.galenos.2019.38257","article-title":"Effect of grape seed extract on bone formation in the expanded inter-premaxillary suture","volume":"21","author":"S Aksakall\u0131","year":"2020","journal-title":"Meandros Med Dent J"},{"issue":"01","key":"ref35","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.25083\/rbl\/26.1\/2347.2354","article-title":"The effects of a grape seed extract on ligature induced \u2013 periodontitis in rats \u2013 an experimental study","volume":"26","author":"T Dimitriu","year":"2021","journal-title":"Rom Biotechnol Lett"},{"issue":"03","key":"ref36","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/jre.12536","article-title":"Morphometric and histopathological evaluation of the effect of grape seed proanthocyanidin on alveolar bone loss in experimental diabetes and periodontitis","volume":"53","author":"H Toker","year":"2018","journal-title":"J Periodontal Res"},{"issue":"05","key":"ref37","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.5504\/BBEQ.2013.0074","article-title":"Effect of grape seed extract upon plasma oxidative status and alveolar bone, in ligature induced periodontitis","volume":"27","author":"M Kara","year":"2013","journal-title":"Biotechnol Biotechnol Equip"},{"issue":"S 02","key":"ref38","first-page":"4877","article-title":"Grape seed extract increase osteoblast number in the post-extraction socket healing in rats","volume":"19","author":"O J Gunardi","year":"2019","journal-title":"Biochem Cell Arch"},{"issue":"01","key":"ref39","first-page":"581","article-title":"Immunohistochemical localization of bone morphogenic protein-2 in extracted tooth socket treated by local application of grape seeds oil in rabbits","volume":"20","author":"M AA Hassan","year":"2020","journal-title":"Biochem Cell Arch"},{"issue":"01","key":"ref40","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1354-523X.2003.00977.x","article-title":"Effects of grape seed proanthocyanidins extract on mandibles in developing rats","volume":"10","author":"Y Kamitani","year":"2004","journal-title":"Oral Dis"},{"issue":"02","key":"ref41","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4012\/dmj.23.67","article-title":"Mechanical evaluation of effect of grape seed proanthocyanidins extract on debilitated mandibles in rats","volume":"23","author":"M Gunjima","year":"2004","journal-title":"Dent Mater J"},{"issue":"03","key":"ref42","first-page":"301","article-title":"Effects of grape seed proanthocyanidins extract on rat mandibular condyle","volume":"4","author":"K Kojima","year":"2004","journal-title":"J Musculoskelet Neuronal Interact"},{"issue":"01","key":"ref43","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s13018-019-1251-5","article-title":"Grape seed extract supplement increases bone callus formation and mechanical strength: an animal study","volume":"14","author":"M Gurger","year":"2019","journal-title":"J Orthop Surg Res"},{"issue":"01","key":"ref44","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0917-2394(04)70008-7","article-title":"Beneficial effects of grape seed proanthocyanidins extract on formation of tibia bone in low-calcium feeding rats","volume":"14","author":"I Tofani","year":"2004","journal-title":"Pediatr Dent J"},{"issue":"02","key":"ref45","first-page":"162","article-title":"Mechanical assessment of effects of grape seed proanthocyanidins extract on tibial bone diaphysis in rats","volume":"5","author":"N Yahara","year":"2005","journal-title":"J Musculoskelet Neuronal Interact"},{"issue":"01","key":"ref46","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0917-2394(05)70026-4","article-title":"Effect of grape seed proanthocyanidins extract on alteration of mechanical properties of metaphysis tibia bone in rats fed a low-calcium diet","volume":"15","author":"J Mitsui","year":"2005","journal-title":"Pediatr Dent J"},{"issue":"01","key":"ref47","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0917-2394(05)70027-6","article-title":"Mechanical evaluation of debilitated tibia diaphysis in rats during the growth period-combination therapy with high-calcium diet and grape seed proanthocyanidin extract-","volume":"15","author":"T Asano","year":"2005","journal-title":"Pediatr Dent J"},{"issue":"10","key":"ref48","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.3390\/nu12103164","article-title":"Grape seed proanthocyanidin extract prevents bone loss via regulation of osteoclast differentiation, apoptosis, and proliferation","volume":"12","author":"S C Kwak","year":"2020","journal-title":"Nutrients"},{"issue":"05","key":"ref49","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1007\/s00580-018-2724-3","article-title":"The impact of grape proanthocyanidin extract on dexamethasone-induced osteoporosis and electrolyte imbalance","volume":"27","author":"N A Hasona","year":"2018","journal-title":"Comp Clin Pathol"},{"issue":"09","key":"ref50","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.3390\/ijms19092746","article-title":"The beneficial effect of proanthocyanidins and icariin on biochemical markers of bone turnover in rats","volume":"19","author":"N Or\u0161oli\u0107","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"01","key":"ref51","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s00776-014-0654-8","article-title":"Beneficial effect of grape seed proanthocyanidin extract in rabbits with steroid-induced osteonecrosis via protecting against oxidative stress and apoptosis","volume":"20","author":"Q Song","year":"2015","journal-title":"J Orthop Sci"},{"issue":"26","key":"ref52","first-page":"4146","article-title":"Grape seed proanthocyanidins antagonize osteocyte apoptosis due to steroid-induced osteonecrosis of the femoral head","volume":"24","author":"Z F Zhang","year":"2020","journal-title":"Chinese Journal of Tissue Engineering Research."},{"issue":"12","key":"ref53","doi-asserted-by":"crossref","first-page":"e51377","DOI":"10.1371\/journal.pone.0051377","article-title":"Grape-seed proanthocyanidin extract as suppressors of bone destruction in inflammatory autoimmune arthritis","volume":"7","author":"J S Park","year":"2012","journal-title":"PLoS One"},{"issue":"10","key":"ref54","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3858\/emm.2011.43.10.062","article-title":"Grape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis","volume":"43","author":"Y J Woo","year":"2011","journal-title":"Exp Mol Med"},{"issue":"01","key":"ref55","first-page":"1","article-title":"Effects of D-002 and grape seed extract on monoiodo-acetate induced osteoarthritis in rats","volume":"37","author":"S Mendoza","year":"2016","journal-title":"Int J Pharm Sci Rev Res"},{"issue":"02","key":"ref56","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.imlet.2009.05.001","article-title":"Grape seed proanthocyanidin extract (GSPE) attenuates collagen-induced arthritis","volume":"124","author":"M L Cho","year":"2009","journal-title":"Immunol Lett"},{"issue":"02","key":"ref57","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1159\/000502235","article-title":"Effects of grape seed proanthocyanidin extract on obesity","volume":"13","author":"M Liu","year":"2020","journal-title":"Obes Facts"},{"issue":"05","key":"ref58","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.3390\/nu13051692","article-title":"Efficacy of bilberry and grape seed extract supplement interventions to improve glucose and cholesterol metabolism and blood pressure in different populations-a systematic review of the literature","volume":"13","author":"T Grohmann","year":"2021","journal-title":"Nutrients"},{"issue":"02","key":"ref59","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1017\/S0007114520000902","article-title":"Effects of grape seed extract on dyslipidaemia: a systematic review and dose-response meta-analysis of randomised controlled trials","volume":"124","author":"J Anjom-Shoae","year":"2020","journal-title":"Br J Nutr"},{"issue":"08","key":"ref60","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.jada.2011.05.015","article-title":"The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials","volume":"111","author":"H HH Feringa","year":"2011","journal-title":"J Am Diet Assoc"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"105905","DOI":"10.1016\/j.phrs.2021.105905","article-title":"The effect of grape (Vitis vinifera) seed extract supplementation on flow-mediated dilation, blood pressure, and heart rate: a systematic review and meta-analysis of controlled trials with duration- and dose-response analysis","volume":"175","author":"S Foshati","year":"2022","journal-title":"Pharmacol Res"},{"issue":"12","key":"ref62","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.3390\/nu11122844","article-title":"Effects of grape seed proanthocyanidin extract on vascular endothelial function in participants with prehypertension: a randomized, double-blind, placebo-controlled study","volume":"11","author":"T Odai","year":"2019","journal-title":"Nutrients"},{"issue":"05","key":"ref63","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1080\/01635581.2015.1029639","article-title":"The role of grape seed extract in the treatment of chemo\/radiotherapy induced toxicity: a systematic review of preclinical studies","volume":"67","author":"O O Olaku","year":"2015","journal-title":"Nutr Cancer"},{"issue":"11","key":"ref64","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1017\/S0007114520003591","article-title":"The effect of grape products containing polyphenols on C-reactive protein levels: a systematic review and meta-analysis of randomised controlled trials","volume":"125","author":"S Sarkhosh-Khorasani","year":"2021","journal-title":"Br J Nutr"},{"issue":"12","key":"ref65","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1002\/ptr.7653","article-title":"The effect of grape products on liver enzymes: a systematic review and meta-analysis of randomized controlled trials","volume":"36","author":"M Zamani","year":"2022","journal-title":"Phytother Res"},{"issue":"02","key":"ref66","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s00284-019-01827-0","article-title":"Effect of black grape seed extract (Vitis vinifera) on biofilm formation of methicillin-resistant Staphylococcus aureus and Staphylococcus haemolyticus","volume":"77","author":"A H Al-Mousawi","year":"2020","journal-title":"Curr Microbiol"},{"issue":"01","key":"ref67","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1166\/jnn.2018.13943","article-title":"Grape seed extract alone or combined with atropine in treatment of malathion induced neuro- and genotoxicity","volume":"18","author":"O ME Abdel-Salam","year":"2018","journal-title":"J Nanosci Nanotechnol"},{"issue":"11","key":"ref68","doi-asserted-by":"crossref","first-page":"21182","DOI":"10.1002\/jcp.28721","article-title":"HIF-1\u03b1 facilitates osteocyte-mediated osteoclastogenesis by activating JAK2\/STAT3 pathway in vitro","volume":"234","author":"J Zhu","year":"2019","journal-title":"J Cell Physiol"},{"issue":"06","key":"ref69","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.3390\/ijms23063233","article-title":"Molecular mechanisms involved in hypoxia-induced alterations in bone remodeling","volume":"23","author":"R Usategui-Mart\u00edn","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.freeradbiomed.2021.04.027","article-title":"Hypoxia inhibits RANKL-induced ferritinophagy and protects osteoclasts from ferroptosis","volume":"169","author":"S Ni","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"110305","DOI":"10.1016\/j.biopha.2020.110305","article-title":"GSH attenuates RANKL-induced osteoclast formation in vitro and LPS-induced bone loss in vivo","volume":"128","author":"B Han","year":"2020","journal-title":"Biomed Pharmacother"},{"issue":"04","key":"ref72","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1142\/S0192415X2050041X","article-title":"Proanthocyanidins: components, pharmacokinetics and biomedical properties","volume":"48","author":"Y X Zeng","year":"2020","journal-title":"Am J Chin Med"},{"issue":"08","key":"ref73","first-page":"4070","article-title":"Inhibition of long non-coding RNA TSIX accelerates tibia fraction healing via binding and positively regulating the SOX6 expression","volume":"24","author":"W W Xu","year":"2020","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"10","key":"ref74","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1359\/jbmr.2001.16.10.1837","article-title":"Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing","volume":"16","author":"H Uusitalo","year":"2001","journal-title":"J Bone Miner Res"},{"issue":"02","key":"ref75","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s00198-011-1626-x","article-title":"Genetic variants in the SOX6 gene are associated with bone mineral density in both Caucasian and Chinese populations","volume":"23","author":"T L Yang","year":"2012","journal-title":"Osteoporos Int"},{"issue":"03","key":"ref76","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s12015-011-9337-4","article-title":"Transcription factor Runx2 and its application to bone tissue engineering","volume":"8","author":"L Dalle Carbonare","year":"2012","journal-title":"Stem Cell Rev Rep"},{"issue":"01","key":"ref77","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1186\/s13287-022-03140-3","article-title":"Runx2 and Nell-1 in dental follicle progenitor cells regulate bone remodeling and tooth eruption","volume":"13","author":"L Zeng","year":"2022","journal-title":"Stem Cell Res Ther"},{"issue":"01","key":"ref78","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/s42003-021-01848-1","article-title":"Dmrt2 promotes transition of endochondral bone formation by linking Sox9 and Runx2","volume":"4","author":"K Ono","year":"2021","journal-title":"Commun Biol"},{"issue":"08","key":"ref79","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1038\/mt.2011.101","article-title":"Synergistic inhibition of endochondral bone formation by silencing Hif1\u03b1 and Runx2 in trauma-induced heterotopic ossification","volume":"19","author":"L Lin","year":"2011","journal-title":"Mol Ther"},{"issue":"05","key":"ref80","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.archoralbio.2005.09.004","article-title":"Alveolar bone osteoblast differentiation and Runx2\/Cbfa1 expression","volume":"51","author":"H Perinpanayagam","year":"2006","journal-title":"Arch Oral Biol"},{"issue":"05","key":"ref81","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1111\/odi.13647","article-title":"Epithelium-Specific Runx2 knockout mice display junctional epithelium and alveolar bone defects","volume":"27","author":"C Xu","year":"2021","journal-title":"Oral Dis"},{"issue":"02","key":"ref82","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/aps.2015.85","article-title":"Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-\u03baB and NFATc1 activation and DC-STAMP expression","volume":"37","author":"X Z Zeng","year":"2016","journal-title":"Acta Pharmacol Sin"},{"issue":"42","key":"ref83","doi-asserted-by":"crossref","first-page":"15395","DOI":"10.1074\/jbc.RA119.010139","article-title":"STAT3 controls osteoclast differentiation and bone homeostasis by regulating NFATc1 transcription","volume":"294","author":"Y Yang","year":"2019","journal-title":"J Biol Chem"},{"issue":"03","key":"ref84","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1530\/JOE-19-0123","article-title":"Homer2 and Homer3 modulate RANKL-induced NFATc1 signaling in osteoclastogenesis and bone metabolism","volume":"242","author":"A Son","year":"2019","journal-title":"J Endocrinol"},{"issue":"01","key":"ref85","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3892\/ijmm.2021.5059","article-title":"Dihydroartemisinin attenuates osteoclast formation and bone resorption via inhibiting the NF\u2011\u03baB, MAPK and NFATc1 signaling pathways and alleviates osteoarthritis","volume":"49","author":"D Ding","year":"2022","journal-title":"Int J Mol Med"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bone.2015.05.012","article-title":"LRP4 in neuromuscular junction and bone development and diseases","volume":"80","author":"C Shen","year":"2015","journal-title":"Bone"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ijbiomac.2017.12.091","article-title":"Matrix metalloproteinase-13: a special focus on its regulation by signaling cascades and microRNAs in bone","volume":"109","author":"S Saiganesh","year":"2018","journal-title":"Int J Biol Macromol"}],"container-title":["European Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1768975.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:56:02Z","timestamp":1730814962000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1768975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,13]]},"references-count":87,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2024,3,22]]},"published-print":{"date-parts":[[2024,2]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1768975","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1305-7456","1305-7464"],"issn-type":[{"type":"print","value":"1305-7456"},{"type":"electronic","value":"1305-7464"}],"subject":[],"published":{"date-parts":[[2023,6,13]]}}}