{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:44:58Z","timestamp":1774313098935,"version":"3.50.1"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Patients with severe steno-occlusive disease of a main cerebral artery without causative lesions on magnetic resonance imaging (MRI) often develop cognitive impairment. However, the effects of revascularization surgery and the source of the cognitive impairment remain unclear. Therefore, we investigated the early postoperative course of cognitive function and its association with cerebral blood flow (CBF), cerebrovascular reserve (CVR), white matter disease (WMD), lacunar infarction, and cerebrovascular risk factors.<\/jats:p><jats:p>\n          Methods\u2003Cognitive function was examined using neurobehavioral cognitive status examination (COGNISTAT) in 52 patients with steno-occlusive disease of a main cerebral artery before and at 6 months after superficial temporal artery\u2013middle cerebral artery (STA\u2013MCA) anastomosis. We examined how cognition changed before and at 1, 3, and 6 months after STA\u2013MCA anastomosis in 27 of 52 patients. CVR and CBF were calculated from 123I-N-isopropyl-p-iodoamphetamine single photon emission computed tomography, in addition to other cerebrovascular risk factors in 34 of 52 patients. Cerebral infarction and WMD (periventricular hyperintensity [PVH] and deep subcortical white matter hyperintensity) were also evaluated preoperatively by MRI.<\/jats:p><jats:p>\n          Results\u2003COGNISTAT scores improved at 1 month after STA\u2013MCA anastomosis in patients with severe steno-occlusive disease of a main cerebral artery. Multiple stepwise regression analysis revealed that CVR (regression coefficient\u2009=\u2009\u20132.237, p\u2009=\u20090.0020) and PVH (regression coefficient\u2009=\u20092.364, p\u2009=\u20090.0029) were the best predictors of postoperative improvement in COGNISTAT scores (R\n          2\u2009=\u20090.415; p\u2009=\u20090.0017).<\/jats:p><jats:p>\n          Conclusion\u2003Cognitive function improves in relation to preoperative CVR and PVH early after STA\u2013MCA anastomosis in patients with steno-occlusive disease of a main cerebral artery.<\/jats:p>","DOI":"10.1055\/s-0043-1769004","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T22:52:47Z","timestamp":1690584767000},"page":"254-261","source":"Crossref","is-referenced-by-count":3,"title":["The Early Postoperative Course of Cognitive Function and Preoperative Cerebrovascular Reserve"],"prefix":"10.1055","volume":"85","author":[{"given":"Masashi","family":"Ikota","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Saitama Medical Center, Jichi Medical University, Saitama-City, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7544-6360","authenticated-orcid":false,"given":"Mami","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Saitama Medical Center, Jichi Medical University, Saitama-City, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Kusaka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Saitama Medical Center, Jichi Medical University, Saitama-City, Saitama, 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