{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:01:52Z","timestamp":1790053312984,"version":"4.0.1"},"reference-count":63,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg A Cent Eur Neurosurg"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background\u2003Insular gliomas (INGs) remain a surgically intimidating glioma subgroup encased by eloquent cortical parcels and white matter language tracts, and traversed by multiple middle cerebral artery branches. The predictive power of prognostic factors affecting overall survival (OS), progression-free survival (PFS), and resectability of INGs remain disputed. This comprehensive systematic review analyses prognostic factors and resectability predictors of INGs substantiating pragmatic management options.<\/jats:p>\n                  <jats:p>Materials and Methods\u2003A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) and the Cochrane Handbook of Systematic Reviews of Interventions guidelines. The PubMed, MEDLINE, and Embase databases were searched in April 2022. All clinical studies with \u226510 patients harboring INGs with any intervention and reporting predictors of OS, PFS, and tumor resectability in INGs were included. Molecular ING prognosticators were also included. Studies combining insular and other gliomas analysis, case studies, experimental and animal studies, conference abstracts, letters to the editor, and articles in other languages were excluded.<\/jats:p>\n                  <jats:p>Results\u2003Of the 2,384 articles returned, 27 fulfilled the inclusion criteria totaling 1,985 patients. The review yielded 18 OS and 17 PFS prognosticators. These were classified as preoperative (radiologic; clinical), intraoperative, and postoperative (molecular; histopathologic; clinical) prognosticators. In addition, 21 resectability predictors were categorized as preoperative (radiologic; clinical), intraoperative (surgical approach and assistive technology), and postoperative (histopathologic; clinical). The quality assessment revealed 24\/27 studies had low risk of bias. One study with moderate and two studies with high risk of bias were included.<\/jats:p>\n                  <jats:p>Conclusion\u2003Negative prognosticators reported in \u22652 studies included putaminal or paralimbic involvement and higher tumor grade, while seizures at presentation, isocitrate dehydrogenase (IDH) mutation, increased extent of resection, and higher Karnofsky Performance Status preoperatively and at 3 months postoperation were positive prognosticators. Resectability predictors reported in \u22652 studies included the positive predictors of zone I\/zone IV tumor location and intraoperative imaging use and the negative predictor of encased lenticulostriate arteries. Paralimbic INGs are not a single entity with homogeneous prognosis. Integration of identified prognosticators in a prospective trial to devise a grading system for INGs can improve clinical decision-making.<\/jats:p>","DOI":"10.1055\/s-0043-1769128","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T19:00:47Z","timestamp":1692903647000},"page":"074-087","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic Factors and Resectability Predictors in Insular Gliomas: A Systematic Review"],"prefix":"10.1055","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9608-2850","authenticated-orcid":false,"given":"Ariadni","family":"Papadopoulou","sequence":"additional","affiliation":[{"name":"Division of Medicine, University College London Medical School, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niraj S.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Medicine, University College London Medical School, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1002\/cncr.20297","article-title":"Preferential brain locations of low-grade gliomas","volume":"100","author":"H Duffau","year":"2004","journal-title":"Cancer"},{"key":"ref2","author":"N Acer"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2009.6.JNS0952","article-title":"Insular glioma resection: assessment of patient morbidity, survival, and tumor progression","volume":"112","author":"N Sanai","year":"2010","journal-title":"J Neurosurg"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"854","DOI":"10.3171\/jns.2003.99.5.0854","article-title":"Progress in long-term survival in adult patients with supratentorial low-grade gliomas: a population-based study of 993 patients in whom tumors were diagnosed between 1970 and 1993","volume":"99","author":"T B Johannesen","year":"2003","journal-title":"J Neurosurg"},{"issue":"01","key":"ref5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1080\/02688697.2020.1859089","article-title":"Insular glioblastoma: surgical challenges, survival outcomes and prognostic factors","volume":"37","author":"A Singh","year":"2023","journal-title":"Br J Neurosurg"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"20354","DOI":"10.18632\/oncotarget.13555","article-title":"Impact of epidemiological characteristics of supratentorial gliomas in adults brought about by the 2016 world health organization classification of tumors of the central nervous system","volume":"8","author":"H Jiang","year":"2017","journal-title":"Oncotarget"},{"issue":"05","key":"ref7","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1227\/NEU.0b013e31820b522a","article-title":"World Health Organization grade II gliomas and subventricular zone: anatomic, genetic, and clinical considerations","volume":"68","author":"F Vergani","year":"2011","journal-title":"Neurosurgery"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s11548-017-1691-5","article-title":"MRI radiomics analysis of molecular alterations in low-grade gliomas","volume":"13","author":"B Shofty","year":"2018","journal-title":"Int J CARS"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1200\/jco.2011.29.15_suppl.2023","article-title":"Triple-negative, low-grade gliomas: a highly aggressive tumor with dismal prognosis","volume":"29","author":"P Metellus","year":"2011","journal-title":"J Clin Oncol"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s00401-010-0777-8","article-title":"Absence of IDH mutation identifies a novel radiologic and molecular subtype of WHO grade II gliomas with dismal prognosis","volume":"120","author":"P Metellus","year":"2010","journal-title":"Acta Neuropathol"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11060-008-9680-8","article-title":"Lack of complete 1p19q deletion in a consecutive series of 12 WHO grade II gliomas involving the insula: a marker of worse prognosis?","volume":"91","author":"C Goz\u00e9","year":"2009","journal-title":"J Neurooncol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"32286","DOI":"10.1038\/srep32286","article-title":"Residual tumor volume as best outcome predictor in low grade glioma: a nine-years near-randomized survey of surgery vs. Biopsy","volume":"6","author":"R Roelz","year":"2016","journal-title":"Sci Rep"},{"issue":"08","key":"ref13","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1200\/JCO.2007.13.9337","article-title":"Role of extent of resection in the long-term outcome of low-grade hemispheric gliomas","volume":"26","author":"J S Smith","year":"2008","journal-title":"J Clin Oncol"},{"issue":"07","key":"ref14","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1007\/s00701-019-03920-6","article-title":"High-field intraoperative MRI and glioma surgery: results after the first 100 consecutive patients","volume":"161","author":"H-A Leroy","year":"2019","journal-title":"Acta Neurochir (Wien)"},{"issue":"02","key":"ref16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.nec.2012.01.010","article-title":"Current surgical management of insular gliomas","volume":"23","author":"Y-H Kim","year":"2012","journal-title":"Neurosurg Clin N Am"},{"issue":"01","key":"ref17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3171\/2018.10.JNS181519","article-title":"Insular glioma surgery: an evolution of thought and practice","volume":"130","author":"S L Hervey-Jumper","year":"2019","journal-title":"J Neurosurg"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration's tool for assessing risk of bias in randomised trials","volume":"343","author":"J PT Higgins","year":"2011","journal-title":"BMJ"},{"issue":"02","key":"ref19","first-page":"148","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"20","author":"D Moher","year":"2016","journal-title":"Rev Esp Nutr Humana Diet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"g7647","DOI":"10.1136\/bmj.g7647","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation","volume":"350","author":"L Shamseer","year":"2015","journal-title":"BMJ"},{"issue":"06","key":"ref21","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary","volume":"131","author":"D N Louis","year":"2016","journal-title":"Acta Neuropathol"},{"issue":"05","key":"ref22","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.3171\/2014.7.JNS13899","article-title":"Practical surgical indicators to identify candidates for radical resection of insulo-opercular gliomas","volume":"121","author":"T Kawaguchi","year":"2014","journal-title":"J Neurosurg"},{"issue":"06","key":"ref23","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.3171\/2016.5.JNS1685","article-title":"Putamen involvement and survival outcomes in patients with insular low-grade gliomas","volume":"126","author":"Y Wang","year":"2017","journal-title":"J Neurosurg"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.wneu.2017.04.002","article-title":"Volumetric analysis of extent of resection, survival, and surgical outcomes for insular gliomas","volume":"103","author":"C I Eseonu","year":"2017","journal-title":"World Neurosurg"},{"issue":"03","key":"ref25","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s11060-019-03122-1","article-title":"Neuro-radiological characteristics of adult diffuse grade II and III insular gliomas classified according to WHO 2016","volume":"142","author":"P Compes","year":"2019","journal-title":"J Neurooncol"},{"issue":"03","key":"ref26","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s11060-015-1989-5","article-title":"Subgroup characteristics of insular low-grade glioma based on clinical and molecular analysis of 42 cases","volume":"126","author":"C Tang","year":"2016","journal-title":"J Neurooncol"},{"issue":"03","key":"ref27","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3171\/2018.4.JNS18424","article-title":"Transcortical insular glioma resection: clinical outcome and predictors","volume":"131","author":"N UF Hameed","year":"2018","journal-title":"J Neurosurg"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.wneu.2019.08.111","article-title":"Effect of treatment modalities on progression-free survival and overall survival in molecularly subtyped world health organization grade II diffuse gliomas: a systematic review","volume":"133","author":"A Ghaffari-Rafi","year":"2020","journal-title":"World Neurosurg"},{"issue":"04","key":"ref30","doi-asserted-by":"crossref","first-page":"280","DOI":"10.7326\/0003-4819-158-4-201302190-00009","article-title":"Assessing bias in studies of prognostic factors","volume":"158","author":"J A Hayden","year":"2013","journal-title":"Ann Intern Med"},{"issue":"06","key":"ref31","doi-asserted-by":"crossref","first-page":"427","DOI":"10.7326\/0003-4819-144-6-200603210-00010","article-title":"Evaluation of the quality of prognosis studies in systematic reviews","volume":"144","author":"J A Hayden","year":"2006","journal-title":"Ann Intern Med"},{"issue":"01","key":"ref32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s41512-019-0050-0","article-title":"Elaborating on the assessment of the risk of bias in prognostic studies in pain rehabilitation using QUIPS-aspects of interrater agreement","volume":"3","author":"W JA Grooten","year":"2019","journal-title":"Diagn Progn Res"},{"issue":"04","key":"ref33","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3171\/2008.7.JNS17639","article-title":"Insular gliomas: the case for surgical management","volume":"110","author":"M Simon","year":"2009","journal-title":"J Neurosurg"},{"issue":"05","key":"ref34","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1227\/NEU.0b013e31823f5be5","article-title":"Surgery of insular nonenhancing gliomas: volumetric analysis of tumoral resection, clinical outcome, and survival in a consecutive series of 66 cases","volume":"70","author":"M Skrap","year":"2012","journal-title":"Neurosurgery"},{"issue":"02","key":"ref35","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00062-014-0287-5","article-title":"Limbic tumors of the temporal lobe: radiologic-pathologic correlation","volume":"25","author":"A A Capizzano","year":"2015","journal-title":"Clin Neuroradiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/BF01405506","article-title":"Interstitial 125-iodine radiosurgery of low-grade gliomas of the insula of Reil","volume":"130","author":"C R Sch\u00e4tz","year":"1994","journal-title":"Acta Neurochir (Wien)"},{"issue":"08","key":"ref37","first-page":"e1623","article-title":"Multilobar insular-involving gliomas: results with hyperaggressive resection","volume":"9","author":"M Sughrue","year":"2017","journal-title":"Cureus"},{"issue":"04","key":"ref38","doi-asserted-by":"crossref","first-page":"866","DOI":"10.3171\/2012.11.JNS121100","article-title":"Distinct IDH1\/IDH2 mutation profiles in purely insular versus paralimbic WHO grade II gliomas","volume":"118","author":"C Goz\u00e9","year":"2013","journal-title":"J Neurosurg"},{"issue":"04","key":"ref39","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3171\/2014.11.JNS141992","article-title":"Subcortical anatomy as an anatomical and functional landmark in insulo-opercular gliomas: implications for surgical approach to the insular region","volume":"123","author":"J Martino","year":"2015","journal-title":"J Neurosurg"},{"issue":"02","key":"ref40","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3171\/2018.4.JNS18375","article-title":"Perioperative outcomes following reoperation for recurrent insular gliomas","volume":"131","author":"R A Morshed","year":"2018","journal-title":"J Neurosurg"},{"issue":"05","key":"ref41","first-page":"696","article-title":"Optimizing the extent of resection and minimizing the morbidity in insular high-grade glioma surgery by high-field intraoperative MRI guidance","volume":"27","author":"L-F Chen","year":"2017","journal-title":"Turk Neurosurg"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.wneu.2016.01.067","article-title":"Intraoperative multi-information-guided resection of dominant-sided insular gliomas in a 3-T intraoperative magnetic resonance imaging integrated neurosurgical suite","volume":"89","author":"D-X Zhuang","year":"2016","journal-title":"World Neurosurg"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.clineuro.2016.08.001","article-title":"Insular gliomas and the role of intraoperative assistive technologies: results from a volumetry-based retrospective cohort","volume":"149","author":"B JAP Barbosa","year":"2016","journal-title":"Clin Neurol Neurosurg"},{"issue":"06","key":"ref44","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/ons\/opab051","article-title":"Transsylvian insular glioma surgery: new classification system, clinical outcome in a consecutive series of 79 cases","volume":"20","author":"D Pitskhelauri","year":"2021","journal-title":"Oper Neurosurg (Hagerstown)"},{"issue":"01","key":"ref45","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11060-009-0100-5","article-title":"High rate of deletion of chromosomes 1p and 19q in insular oligodendroglial tumors","volume":"99","author":"A Wu","year":"2010","journal-title":"J Neurooncol"},{"issue":"02","key":"ref46","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/00013414-200306000-00009","article-title":"New classification for insular tumors and surgical results of 40 patients","volume":"13","author":"E Ozyurt","year":"2003","journal-title":"Neurosurg Q"},{"issue":"05","key":"ref47","doi-asserted-by":"crossref","first-page":"825","DOI":"10.3171\/JNS\/2008\/109\/11\/0825","article-title":"Resection of insular gliomas: the importance of lenticulostriate artery position","volume":"109","author":"Y A Moshel","year":"2008","journal-title":"J Neurosurg"},{"issue":"06","key":"ref48","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.3171\/2018.12.JNS183075","article-title":"Surgical morbidity of transsylvian versus transcortical approaches to insular gliomas","volume":"132","author":"C J Przybylowski","year":"2019","journal-title":"J Neurosurg"},{"issue":"01","key":"ref49","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11060-020-03390-2","article-title":"Transcortical approach for insular gliomas: a series of 253 patients","volume":"147","author":"Z Li","year":"2020","journal-title":"J Neurooncol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"629166","DOI":"10.3389\/fonc.2021.629166","article-title":"Challenging giant insular gliomas with brain mapping: evaluation of neurosurgical, neurological, neuropsychological, and quality of life results in a large mono-institutional series","volume":"11","author":"M Rossi","year":"2021","journal-title":"Front Oncol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"e426","DOI":"10.1016\/j.wneu.2017.09.199","article-title":"Analogous three-dimensional constructive interference in steady state sequences enhance the utility of three-dimensional time of flight magnetic resonance angiography in delineating lenticulostriate arteries in insular gliomas: evidence from a prospective clinicoradiologic analysis of 48 patients","volume":"109","author":"A S Rao","year":"2018","journal-title":"World Neurosurg"},{"issue":"02","key":"ref52","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3171\/2014.12.JNS142182","article-title":"Surgical assessment of the insula. Part 1: surgical anatomy and morphometric analysis of the transsylvian and transcortical approaches to the insula","volume":"124","author":"A Benet","year":"2016","journal-title":"J Neurosurg"},{"issue":"02","key":"ref53","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3171\/2008.11.JNS08858","article-title":"Magnetic resonance imaging for preoperative identification of the lenticulostriate arteries in insular glioma surgery. Technical note","volume":"111","author":"R Saito","year":"2009","journal-title":"J Neurosurg"},{"issue":"12","key":"ref54","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.1158\/0008-5472.CAN-07-0760","article-title":"Tumorigenesis in the brain: location, location, location","volume":"67","author":"R J Gilbertson","year":"2007","journal-title":"Cancer Res"},{"issue":"34","key":"ref55","doi-asserted-by":"crossref","first-page":"4482","DOI":"10.1200\/JCO.2010.33.8715","article-title":"Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin","volume":"29","author":"A Lai","year":"2011","journal-title":"J Clin Oncol"},{"issue":"02","key":"ref56","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/ene.12578","article-title":"Anatomical localization of isocitrate dehydrogenase 1 mutation: a voxel-based radiographic study of 146 low-grade gliomas","volume":"22","author":"Y Wang","year":"2015","journal-title":"Eur J Neurol"},{"key":"ref57","first-page":"4","article-title":"New insights into the anatomic dissection of the temporal stem with special emphasis on the inferior fronto-occipital fasciculus: implications in surgical approach to left mesiotemporal and temporoinsular structures","volume":"66","author":"J Martino","year":"2010","journal-title":"Neurosurgery"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/neuros\/nyx417.380","article-title":"Seizure outcome after surgical resection of insular glioma","volume":"64","author":"D D Wang","year":"2017","journal-title":"Clin Neurosurg"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/brain\/awt345","article-title":"Epileptic seizures in diffuse low-grade gliomas in adults","volume":"137","author":"J Pallud","year":"2014","journal-title":"Brain"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/epi.12437","article-title":"Seizure characteristics and prognostic factors of gliomas","volume":"54","author":"M Kerkhof","year":"2013","journal-title":"Epilepsia"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"e539","DOI":"10.1016\/j.wneu.2017.12.112","article-title":"Association between IDH1 and IDH2 mutations and preoperative seizures in patients with low-grade versus high-grade glioma: a systematic review and meta-analysis","volume":"111","author":"K Phan","year":"2018","journal-title":"World Neurosurg"},{"issue":"19","key":"ref62","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1212\/WNL.0000000000003911","article-title":"Mutant IDH1 and seizures in patients with glioma","volume":"88","author":"H Chen","year":"2017","journal-title":"Neurology"},{"issue":"02","key":"ref63","doi-asserted-by":"crossref","first-page":"E332","DOI":"10.1093\/neuros\/nyy481","article-title":"Extent of resection and residual tumor thresholds for postoperative total seizure freedom in epileptic adult patients harboring a supratentorial diffuse low-grade glioma","volume":"85","author":"M EH Still","year":"2019","journal-title":"Neurosurgery"},{"issue":"03","key":"ref64","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1227\/01.NEU.0000349763.42238.E9","article-title":"Association of surgically acquired motor and language deficits on overall survival after resection of glioblastoma multiforme","volume":"65","author":"M J McGirt","year":"2009","journal-title":"Neurosurgery"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/BF01400725","article-title":"Tumours of the limbic and paralimbic systems","volume":"118","author":"M G Ya\u015fargil","year":"1992","journal-title":"Acta Neurochir (Wien)"}],"container-title":["Journal of Neurological Surgery Part A: Central European Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1769128.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T06:02:41Z","timestamp":1730786561000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1769128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,24]]},"references-count":63,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2024,1,3]]},"published-print":{"date-parts":[[2024,1]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1769128","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6315","2193-6323"],"issn-type":[{"value":"2193-6315","type":"print"},{"value":"2193-6323","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,24]]}}}