{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T10:22:10Z","timestamp":1755598930081,"version":"3.37.3"},"reference-count":46,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003Coronavirus disease (COVID-19) during pregnancy may have an impact on preterm morbidities due to the inflammatory nature of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Exposure to intrauterine inflammation could result in adverse consequences in preterm infants. We aimed to determine the effect of maternal coronavirus disease on preterm morbidities at a tertiary neonatal intensive care unit.<\/jats:p><jats:p>\n            Study Design\u2003This observational cohort study compared the clinical outcomes of preterm infants\u2009&lt;\u200937 gestational weeks with and without maternal COVID-19. The study was conducted in a tertiary-level neonatal intensive care unit between March 2020 and December 2021. Demographics and clinical data of the study groups were collected from the medical files.<\/jats:p><jats:p>\n            Results\u2003A total of 254 infants (127 in the maternal COVID-19 group and 127 in the control group) were included in the study. Respiratory distress syndrome, early and late neonatal sepsis, intraventricular hemorrhage, patent ductus arteriosus (PDA), necrotizing enterocolitis, bronchopulmonary dysplasia, and retinopathy of prematurity rates were similar between groups. In the subgroup analysis, the rate of PDA was significantly higher in preterm infants \u22641,500\u2009g with maternal SARS-CoV-2 infection (38 vs. 15% p\u2009=\u20090.023). Presence of maternal COVID-19 was found to be an independent predictor for PDA in very low birthweight infants, as revealed by multivariate analyses (odds ratio: 3.4; 95% confidence interval: 1.12\u201310.4; p\u2009=\u20090.031). Mortality rates and duration of hospitalization were similar in both groups.<\/jats:p><jats:p>\n            Conclusion\u2003Our results suggest that COVID-19 infection during pregnancy seems to have no adverse effect on preterm morbidities and mortality. However, maternal COVID-19 was found to be a risk factor for PDA in preterm infants \u22641,500\u2009g.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0043-1769471","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T23:10:29Z","timestamp":1685574629000},"page":"e1835-e1840","source":"Crossref","is-referenced-by-count":3,"special_numbering":"S","title":["Effect of Maternal Coronavirus Disease on Preterm Morbidities"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5853-3665","authenticated-orcid":false,"given":"G\u00f6k\u00e7e","family":"\u00c7\u0131plak","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Neonatal Intensive Care Unit, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem","family":"Becerir","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Neonatal Intensive Care Unit, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4643-7622","authenticated-orcid":false,"given":"Fatma N.","family":"Sar\u0131","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Neonatal Intensive Care Unit, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8956-0917","authenticated-orcid":false,"given":"Evrim","family":"Alyama\u00e7 Dizdar","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Neonatal Intensive Care Unit, University of Health Sciences, Ankara Bilkent City Hospital, Ankara, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/ijgo.14015","article-title":"Consequences and implications of the coronavirus disease (COVID-19) on pregnancy and newborns: a comprehensive systematic review and meta-analysis","volume":"156","author":"K S de Medeiros","year":"2022","journal-title":"Int J Gynaecol Obstet"},{"issue":"02","key":"ref2","first-page":"167","article-title":"COVID-19 and pregnancy: a narrative review of maternal and perinatal outcomes","volume":"22","author":"N Al Riyami","year":"2022","journal-title":"Sultan Qaboos Univ Med J"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"e13306","DOI":"10.1111\/aji.13306","article-title":"COVID-19 in pregnancy: placental and neonatal involvement","volume":"84","author":"E Prochaska","year":"2020","journal-title":"Am J Reprod Immunol"},{"volume-title":"Immunology at the Maternal-Fetal Interface. 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