{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:22:30Z","timestamp":1782231750010,"version":"3.54.5"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropediatrics"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003For patients with pharmacoresistant epilepsy, a therapeutic option is ketogenic diet. Currently, data on young infants are scarce, particularly during hospitalization in the neonatal intensive care unit (NICU).<\/jats:p><jats:p>\n          Objective\u2003The aim of the present study was to evaluate the short-term (3-month) efficacy and side effects of ketogenic diet in infants with \u201cdrugs-resistant\u201d epilepsy treated during NICU stay.<\/jats:p><jats:p>\n          Methods\u2003This retrospective study included infants aged under 2 months started on ketogenic diet during NICU hospitalization to treat drug-resistant epilepsy from April 2018 to November 2022.<\/jats:p><jats:p>\n          Results\u2003Thirteen term-born infants were included, three (23.1%) of whom were excluded because they did not respond to the ketogenic diet. Finally, we included 10 infants. Six (60%) patients took three antiepileptics before starting the ketogenic diet, while four (40%) took more drugs. Diet had a good response in four (40%) patients. In four patients, the ketogenic diet was suspended because of the onset of serious side effects. The emetic levels of sodium, potassium, and chlorine, pH, and onset of diarrhea, constipation, and gastroesophageal reflux showed significant differences. Ketonuria was higher and blood pH lower in the group that took more than three drugs than in the group taking fewer than three drugs.<\/jats:p><jats:p>\n          Conclusion\u2003The ketogenic diet is efficacious and safe in infants, but the early and aggressive management of adverse reactions is important to improve the safety and effectiveness of the ketogenic treatment.<\/jats:p>","DOI":"10.1055\/s-0043-1769505","type":"journal-article","created":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T22:44:27Z","timestamp":1686869067000},"page":"315-321","source":"Crossref","is-referenced-by-count":6,"title":["Ketogenic Diet in Neonates with Drug-Resistant Epilepsy: Efficacy and Side Effects\u2014A Single Center's Initial Experience"],"prefix":"10.1055","volume":"54","author":[{"given":"Raffaele","family":"Falsaperla","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit and Neonatal Accompaniment Unit, Azienda Ospedaliero-Universitaria Policlinico \u201cRodolico-San Marco,\u201d San Marco Hospital, University of Catania, Catania, Italy"},{"name":"Unit of Pediatrics and Pediatric Emergency, Azienda Ospedaliero-Universitaria Policlinico, \u201cRodolico-San Marco,\u201d San Marco Hospital, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Sortino","sequence":"additional","affiliation":[{"name":"Unit of Pediatrics and Pediatric Emergency, Azienda Ospedaliero-Universitaria Policlinico, \u201cRodolico-San Marco,\u201d San Marco Hospital, Catania, Italy"},{"name":"Postgraduate Training Program in Pediatrics, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ausilia Desiree","family":"Collotta","sequence":"additional","affiliation":[{"name":"Unit of Pediatrics and Pediatric Emergency, Azienda Ospedaliero-Universitaria Policlinico, \u201cRodolico-San Marco,\u201d San Marco Hospital, Catania, Italy"},{"name":"Postgraduate Training Program in Pediatrics, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grete Francesca","family":"Privitera","sequence":"additional","affiliation":[{"name":"Unit of Math and Comp Science, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Palmeri","sequence":"additional","affiliation":[{"name":"Postgraduate Training Program in Pediatrics, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Mauceri","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit and Neonatal Accompaniment Unit, Azienda Ospedaliero-Universitaria Policlinico \u201cRodolico-San Marco,\u201d San Marco Hospital, University of Catania, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martino","family":"Ruggieri","sequence":"additional","affiliation":[{"name":"Unit of Clinical Pediatrics and Unit of Rare Diseases of the Nervous System in Childhood, Department of Clinical and Experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, Policlinico Hospital, Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,6,15]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/epi.12046","article-title":"A population-based study of newly diagnosed epilepsy in infants","volume":"54","author":"C M Eltze","year":"2013","journal-title":"Epilepsia"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"e20163908","DOI":"10.1542\/peds.2016-3908","article-title":"Incidence and prevalence of childhood 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