{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T10:43:08Z","timestamp":1785580988824,"version":"3.56.0"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>\n            Background\u2003Women of childbearing age are exposed to venous thromboembolic risk mainly for pregnancy and use of oral contraceptives. The impact of risk factors (RF) on venous thromboembolism (VTE) in these circumstances is still unclear.<\/jats:p><jats:p>\n            Aim\u2003In the context of START registry, we aimed to investigate the weight of a series of RF on the occurrence of pregnancy- or combined oral contraceptive (COC)-associated VTE.<\/jats:p><jats:p>\n            Materials and Methods\u2003We selected all women included in the START for VTE occurred between 18\u201342 years and compared those with a first or recurrent pregnancy\/postpartum- (group A) or COC-VTE (group B) with those who had VTE outside these circumstances (group C). Final analysis included a cohort of 532 women. Follow-up data showed that there were no significant differences between the groups in terms of thrombotic and haemorrhagic complications. As for pregnancy-associated VTE, the overall outcome was good in terms of both maternal and fetal prognosis.<\/jats:p><jats:p>\n            Results\u2003In a binary model of logistic regression, correcting for potential confounders, VTE family history conferred a significant and independent higher risk of COC-VTE compared with group C. Similarly, comparison between group A and C documented that family history significantly affected the risk of pregnancy-associated VTE. VTE in the group C was significantly associated with older age. Lastly, smoke was a significant risk factor for pregnancy\/postpartum VTE when group A and group B were compared.<\/jats:p><jats:p>\n            Conclusion\u2003Present data suggest that in the setting of fertile women, family history of VTE has a greater role in predicting COC- and pregnancy\/postpartum- VTE than outside these circumstances.<\/jats:p>","DOI":"10.1055\/s-0043-1769592","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T23:14:30Z","timestamp":1685661270000},"page":"1060-1068","source":"Crossref","is-referenced-by-count":12,"title":["Venous Thromboembolism in Women of Childbearing Age: Insights from the START Registry"],"prefix":"10.1055","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8980-9783","authenticated-orcid":false,"given":"Elvira","family":"Grandone","sequence":"additional","affiliation":[{"name":"Thrombosis and Haemostasis Unit, Fondazione IRCCS \u201cCasa Sollievo della Sofferenza,\u201d San Giovanni Rotondo, Italy"},{"name":"Ob\/Gyn Department, University of Foggia, Foggia, Italy"},{"name":"Ob\/Gyn and Perinatal Medicine Department of The First I.M. Sechenov Moscow State Medical University, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Antonucci","sequence":"additional","affiliation":[{"name":"Fondazione Arianna Anticoagulazione, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Colaizzo","sequence":"additional","affiliation":[{"name":"Thrombosis and Haemostasis Unit, Fondazione IRCCS \u201cCasa Sollievo della Sofferenza,\u201d San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"De Laurenzo","sequence":"additional","affiliation":[{"name":"Thrombosis and Haemostasis Unit, Fondazione IRCCS \u201cCasa Sollievo della Sofferenza,\u201d San Giovanni Rotondo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benilde","family":"Cosmi","sequence":"additional","affiliation":[{"name":"UO di Angiologia e Malattie della Coagulazione, Dipartimento Medicina Specialistica, Diagnostica e Sperimentale, Universit\u00e0 di Bologna; Azienda Ospedaliero Universitaria S. Orsola-Malpighi, IRCCS, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Cini","sequence":"additional","affiliation":[{"name":"Fondazione Arianna Anticoagulazione, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Legnani","sequence":"additional","affiliation":[{"name":"Fondazione Arianna Anticoagulazione, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Testa","sequence":"additional","affiliation":[{"name":"Centro Emostasi e Trombosi, UUOO Laboratorio Analisi chimico-cliniche e microbiologiche, ASST Cremona, Cremona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Margaglione","sequence":"additional","affiliation":[{"name":"Medical Genetics, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gualtiero","family":"Palareti","sequence":"additional","affiliation":[{"name":"Fondazione Arianna Anticoagulazione, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,6,1]]},"reference":[{"issue":"07","key":"ref1","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.0001-6349.2004.00574.x","article-title":"Incidence of venous thromboembolism in young Swedish women and possibly preventable cases among combined oral contraceptive users","volume":"83","author":"E Samuelsson","year":"2004","journal-title":"Acta Obstet Gynecol Scand"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"d6423","DOI":"10.1136\/bmj.d6423","article-title":"Risk of venous thromboembolism from use of oral contraceptives containing different progestogens and oestrogen doses: Danish cohort study, 2001-9","volume":"343","author":"\u00d8 Lidegaard","year":"2011","journal-title":"BMJ"},{"issue":"03","key":"ref3","first-page":"CD010813","article-title":"Combined oral contraceptives: venous thrombosis","author":"M de Bastos","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.fertnstert.2016.09.027","article-title":"Electronic address: ASRM@asrm.org; Practice Committee of the American Society for Reproductive Medicine. 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