{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T04:10:35Z","timestamp":1767154235377,"version":"build-2238731810"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"S 01","funder":[{"name":"Indiana Clinical and Translational Sciences Institute's Indiana Medical Student Program for Research and Scholarship"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["UL1TR002529"],"award-info":[{"award-number":["UL1TR002529"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R01HD088014"],"award-info":[{"award-number":["R01HD088014"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>Objective\u2003This study aimed to analyze characteristics of those seen for threatened preterm labor (tPTL) who receive antenatal corticosteroids (ACS) to better understand clinical decision-making.<\/jats:p>\n                  <jats:p>Study Design\u2003This retrospective cohort study consisted of patients seen in triage at an urban county hospital in 2021 for tPTL during pregnancy. Demographic variables (maternal age, race\/ethnicity, and prior preterm delivery) and obstetrical variables (cervical dilation, effacement, membrane rupture, and tocolytic administration) were evaluated against the primary outcome of ACS administration.<\/jats:p>\n                  <jats:p>Results\u2003After exclusions, a cohort of 290 pregnant people with 372 unique encounters for tPTL remained. The mean maternal age was 26.7, and 15.6% of patients had a history of prior preterm birth. A total of 107 patients in 111 encounters received ACS, which were associated with lower body mass index (BMI), greater cervical dilation, greater effacement, membrane rupture, and more frequent contractions (all ps\u2009&lt;\u20090.01). The mean presentation was at 33.5 weeks. Only 44% of those receiving ACS delivered within 7 days, compared with 11% of those who did not receive ACS (p\u2009&lt;\u20090.001). Half (50%) of the patients receiving ACS delivered at &gt;37 weeks. Adjusting for significant factors in the univariable analysis and limited to first encounter in triage, BMI (odds ratio: 0.91, 95% confidence interval: 0.87\u20130.95), cervical dilation \u2265 2\u2009cm (2.49, 1.12\u20135.35), and cervical effacement \u2265 50% (4.80, 2.25\u201310.24) were significantly associated with patients receiving ACS.<\/jats:p>\n                  <jats:p>Conclusion\u2003Greater cervical dilation and effacement and a lower BMI were associated with ACS administration, although most patients receiving ACS still did not deliver within 7 days.<\/jats:p>\n                  <jats:p>Key Points<\/jats:p>","DOI":"10.1055\/s-0043-1769794","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T19:32:47Z","timestamp":1686079967000},"page":"e1917-e1924","source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Analysis of Factors Contributing to Antenatal Corticosteroid Administration in Patients Presenting with Threatened Preterm Labor"],"prefix":"10.1055","volume":"41","author":[{"given":"Leah","family":"Bode","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra H.","family":"McKinzie","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia M.","family":"Gidia","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherrine A.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8379-0743","authenticated-orcid":false,"given":"David M.","family":"Haas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/aogs.13104","article-title":"Use of antenatal corticosteroids in special circumstances: a comprehensive review","volume":"96","author":"E F Magann","year":"2017","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0002-9378(97)70431-9","article-title":"Fetal fibronectin as a predictor of preterm birth in patients with symptoms: a multicenter 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corticosteroids","volume":"228","author":"S J Osteen","year":"2022","journal-title":"Am J Obstet Gynecol"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"e141","DOI":"10.1055\/s-0035-1552930","article-title":"Predictive factors for delivery within 7 days after successful 48-hour treatment of threatened preterm labor","volume":"5","author":"C Roos","year":"2015","journal-title":"AJP Rep"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"8367571","DOI":"10.1155\/2018\/8367571","article-title":"Prediction of preterm birth: maternal characteristics, ultrasound markers, and biomarkers: an updated overview","volume":"2018","author":"Z A Oskovi Kaplan","year":"2018","journal-title":"J Pregnancy"},{"issue":"10","key":"ref9","first-page":"1261","article-title":"[Predictive tools of preterm birth in asymptomatic high-risk pregnancy]","volume":"45","author":"J Blanc","year":"2016","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/uog.15871","article-title":"Contraction-based uterine artery Doppler velocimetry: novel approach for prediction of preterm birth in women with threatened preterm labor","volume":"48","author":"S Olgan","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref12","volume-title":"WHO recommendations on interventions to improve preterm birth outcomes","author":"World Health Organization","year":"2015"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bpobgyn.2020.09.003","article-title":"Preterm birth prevention","volume":"69","author":"E B da Fonseca","year":"2020","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/uog.17388","article-title":"Cervical length screening for prevention of preterm birth in singleton pregnancy with threatened preterm labor: systematic review and meta-analysis of randomized controlled trials using individual patient-level data","volume":"49","author":"V Berghella","year":"2017","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/uog.3908","article-title":"Targeted therapy for threatened preterm labor based on sonographic measurement of the cervical length: a randomized controlled trial","volume":"29","author":"Z Alfirevic","year":"2007","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"04","key":"ref16","doi-asserted-by":"crossref","first-page":"426.e1","DOI":"10.1016\/j.ajog.2007.07.017","article-title":"Does knowledge of cervical length and fetal fibronectin affect management of women with threatened preterm labor? 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