{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T01:56:18Z","timestamp":1793325378151,"version":"4.5.0"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Respir Crit Care Med"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pulmonary hypertension (PH) is a pathophysiological manifestation of a heterogeneous group of diseases characterized by abnormally elevated pulmonary arterial pressures diagnosed on right heart catheterization. The 2022 European Society of Cardiology (ESC) and European Respiratory Society (ERS) Guidelines for the diagnosis and treatment of PH provides a new hemodynamic definition to define PH by lowering the threshold of the mean pulmonary artery pressure (mPAP) to 20\u2009mm Hg. Precapillary PH is thus now defined as a mPAP &gt;20\u2009mm Hg together with a normal pulmonary artery wedge pressure (&lt;15\u2009mm Hg) and an increased pulmonary vascular resistance (&gt;2 Wood Units). The ESC\/ERS 2022 Guidelines also introduce a revised clinical classification of PH while retaining its previous distinction between the five groups according to the underlying pathophysiology.<\/jats:p>","DOI":"10.1055\/s-0043-1770115","type":"journal-article","created":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T22:50:53Z","timestamp":1692399053000},"page":"721-727","source":"Crossref","is-referenced-by-count":7,"title":["Updated Hemodynamic Definition and Classification of Pulmonary Hypertension"],"prefix":"10.1055","volume":"44","author":[{"given":"Benoit","family":"Lechartier","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Center, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, France"},{"name":"School of Medicine, Universit\u00e9 Paris-Saclay, Le Kremlin-Bic\u00eatre, France"},{"name":"INSERM UMR_S 999 \u201cPulmonary Hypertension: Pathophysiology and Novel Therapies,\u201d H\u00f4pital Marie Lannelongue, Le Plessis-Robinson, France"},{"name":"Respiratory Division, Lausanne University Hospital (CHUV), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithum","family":"Kularatne","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Center, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, France"},{"name":"School of Medicine, Universit\u00e9 Paris-Saclay, Le Kremlin-Bic\u00eatre, France"},{"name":"INSERM UMR_S 999 \u201cPulmonary Hypertension: Pathophysiology and Novel Therapies,\u201d H\u00f4pital Marie Lannelongue, Le Plessis-Robinson, France"},{"name":"Division of Respiratory Medicine, Department of Medicine, University of Calgary, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Ja\u00efs","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Center, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, France"},{"name":"School of Medicine, Universit\u00e9 Paris-Saclay, Le Kremlin-Bic\u00eatre, France"},{"name":"INSERM UMR_S 999 \u201cPulmonary Hypertension: Pathophysiology and Novel Therapies,\u201d H\u00f4pital Marie Lannelongue, Le Plessis-Robinson, France"},{"name":"European Reference Network on Rare Pulmonary Diseases (ERN-LUNG), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Humbert","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Center, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, France"},{"name":"School of Medicine, Universit\u00e9 Paris-Saclay, Le Kremlin-Bic\u00eatre, France"},{"name":"INSERM UMR_S 999 \u201cPulmonary Hypertension: Pathophysiology and Novel Therapies,\u201d H\u00f4pital Marie Lannelongue, Le Plessis-Robinson, France"},{"name":"European Reference Network on Rare Pulmonary Diseases (ERN-LUNG), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Montani","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Center, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Bic\u00eatre, Le Kremlin-Bic\u00eatre, France"},{"name":"School of Medicine, Universit\u00e9 Paris-Saclay, Le Kremlin-Bic\u00eatre, France"},{"name":"INSERM UMR_S 999 \u201cPulmonary Hypertension: Pathophysiology and Novel Therapies,\u201d H\u00f4pital Marie Lannelongue, Le Plessis-Robinson, France"},{"name":"European Reference Network on Rare Pulmonary Diseases (ERN-LUNG), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,8,18]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"2200879","DOI":"10.1183\/13993003.00879-2022","article-title":"ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"61","author":"M Humbert","year":"2023","journal-title":"Eur Respir J"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrcardio.2017.84","article-title":"Epidemiology and treatment of pulmonary arterial hypertension","volume":"14","author":"E MT Lau","year":"2017","journal-title":"Nat Rev Cardiol"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S2213-2600(15)00543-3","article-title":"A global view of pulmonary hypertension","volume":"4","author":"M M 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