{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:03:54Z","timestamp":1790391834882,"version":"4.1.0"},"reference-count":50,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Respir Crit Care Med"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The right ventricle plays a pivotal role in patients with pulmonary hypertension (PH). Its adaptation to pressure overload determines a patient's functional status as well as survival. In a healthy situation, the right ventricle is part of a low pressure, high compliance system. It is built to accommodate changes in preload, but not very well suited for dealing with pressure overload. In PH, right ventricular (RV) contractility must increase to maintain cardiac output. In other words, the balance between the degree of RV contractility and afterload determines stroke volume. Hypertrophy is one of the major hallmarks of RV adaptation, but it may cause stiffening of the ventricle in addition to intrinsic changes to the RV myocardium. Ventricular filling becomes more difficult for which the right atrium tries to compensate through increased stroke work. Interaction of RV diastolic stiffness and right atrial (RA) function determines RV filling, but also causes vena cava backflow. Assessment of RV and RA function is critical in the evaluation of patient status. In recent guidelines, this is acknowledged by incorporating additional RV parameters in the risk stratification in PH. Several conventional parameters of RV and RA function have been part of risk stratification for many years. Understanding the pathophysiology of RV failure and the interactions with the pulmonary circulation and right atrium requires consideration of the unique RV anatomy. This review will therefore describe normal RV structure and function and changes that occur during adaptation to increased afterload. Consequences of a failing right ventricle and its implications for RA function will be discussed. Subsequently, we will describe RV and RA assessment in clinical practice.<\/jats:p>","DOI":"10.1055\/s-0043-1770117","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T22:52:57Z","timestamp":1690239177000},"page":"738-745","source":"Crossref","is-referenced-by-count":15,"title":["The Right Ventricle in Pulmonary Hypertension"],"prefix":"10.1055","volume":"44","author":[{"given":"Jeroen N.","family":"Wessels","sequence":"additional","affiliation":[{"name":"PHEniX Laboratory, Department of Pulmonary Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"},{"name":"Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands"},{"name":"European Reference Network on Rare Pulmonary Diseases (ERN-LUNG), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas R.","family":"Celant","sequence":"additional","affiliation":[{"name":"PHEniX Laboratory, Department of Pulmonary Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"},{"name":"Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands"},{"name":"European Reference Network on Rare Pulmonary Diseases (ERN-LUNG), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances S.","family":"de Man","sequence":"additional","affiliation":[{"name":"PHEniX Laboratory, Department of Pulmonary Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"},{"name":"Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands"},{"name":"European Reference Network on Rare Pulmonary Diseases (ERN-LUNG), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton Vonk","family":"Noordegraaf","sequence":"additional","affiliation":[{"name":"PHEniX Laboratory, Department of Pulmonary Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"},{"name":"Amsterdam Cardiovascular Sciences, Pulmonary Hypertension and Thrombosis, Amsterdam, The Netherlands"},{"name":"European Reference Network on Rare Pulmonary Diseases (ERN-LUNG), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,7,24]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jacc.2016.10.047","article-title":"The relationship between the right ventricle and its load in pulmonary hypertension","volume":"69","author":"A Vonk Noordegraaf","year":"2017","journal-title":"J Am Coll Cardiol"},{"issue":"24","key":"ref2","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1016\/j.jacc.2011.06.068","article-title":"Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapy","volume":"58","author":"M C van de Veerdonk","year":"2011","journal-title":"J Am Coll 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Haddad","year":"2008","journal-title":"Circulation"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1093\/eurheartj\/ehl477","article-title":"Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension","volume":"28","author":"S A van Wolferen","year":"2007","journal-title":"Eur Heart J"},{"issue":"07","key":"ref7","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.jacc.2007.10.041","article-title":"Interventricular mechanical asynchrony in pulmonary arterial hypertension: left-to-right delay in peak shortening is related to right ventricular overload and left ventricular underfilling","volume":"51","author":"J T Marcus","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1067\/mje.2002.123962","article-title":"Right atrial size and tricuspid regurgitation severity predict mortality or transplantation in primary 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Ghio","year":"2020","journal-title":"Eur Respir J"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1164\/rccm.201909-1771OC","article-title":"Identification of cardiac magnetic resonance imaging thresholds for risk stratification in pulmonary arterial hypertension","volume":"201","author":"R A Lewis","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"issue":"05","key":"ref13","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1067\/mtc.2002.122439","article-title":"Basic science review: the helix and the heart","volume":"124","author":"G D Buckberg","year":"2002","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/0146-2806(91)90009-Y","article-title":"The right ventricle: anatomy, physiology, and clinical importance","volume":"16","author":"L J Dell'Italia","year":"1991","journal-title":"Curr Probl 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Tello","year":"2019","journal-title":"JACC Cardiovasc Imaging"},{"issue":"06","key":"ref24","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1183\/09031936.00156714","article-title":"Clinical relevance of right ventricular diastolic stiffness in pulmonary hypertension","volume":"45","author":"P Trip","year":"2015","journal-title":"Eur Respir J"},{"issue":"04","key":"ref25","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.chest.2021.09.040","article-title":"The right ventricular-pulmonary arterial coupling and diastolic function response to therapy in pulmonary arterial hypertension","volume":"161","author":"R R Vanderpool","year":"2022","journal-title":"Chest"},{"issue":"06","key":"ref26","doi-asserted-by":"crossref","first-page":"2101454","DOI":"10.1183\/13993003.01454-2021","article-title":"Right atrial function is associated with right ventricular diastolic stiffness: RA-RV interaction in pulmonary arterial hypertension","volume":"59","author":"J N 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