{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:42:43Z","timestamp":1792651363047,"version":"4.5.0"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ortop (Sao Paulo)"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Resumo<\/jats:title><jats:p>O aumento da expectativa de vida da popula\u00e7\u00e3o mundial levou a incremento concomitante na preval\u00eancia de mieloma m\u00faltiplo (MM), patologia que geralmente afeta a popula\u00e7\u00e3o idosa. Les\u00f5es \u00f3sseas s\u00e3o frequentes nos portadores desta condi\u00e7\u00e3o, demandando abordagem precoce, desde o tratamento medicamentoso, passando pela radioterapia at\u00e9 a cirurgia ortop\u00e9dica (profil\u00e1tica ou terap\u00eautica) com os objetivos de prevenir ou retardar a ocorr\u00eancia de fratura, ou, quando este evento j\u00e1 ocorreu, trat\u00e1-la mediante estabiliza\u00e7\u00e3o ou substitui\u00e7\u00e3o (les\u00f5es situadas no esqueleto apendicular) e\/ou promover estabiliza\u00e7\u00e3o e descompress\u00e3o medular (les\u00f5es situadas no esqueleto axial), proporcionando r\u00e1pido al\u00edvio da dor, retorno \u00e0 deambula\u00e7\u00e3o e ressocializa\u00e7\u00e3o, devolvendo a qualidade de vida aos pacientes. O objetivo desta revis\u00e3o \u00e9 atualizar o leitor sobre a fisiopatologia, a cl\u00ednica, exames laboratoriais e de imagem, diagn\u00f3stico diferencial e abordagem terap\u00eautica da doen\u00e7a \u00f3ssea no mieloma m\u00faltiplo (DOMM).<\/jats:p>","DOI":"10.1055\/s-0043-1770150","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T22:33:38Z","timestamp":1688078018000},"page":"368-377","source":"Crossref","is-referenced-by-count":3,"title":["Mieloma M\u00faltiplo (Parte 2) - Atualiza\u00e7\u00e3o sobre a Abordagem da Doen\u00e7a \u00d3ssea"],"prefix":"10.1055","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7013-7107","authenticated-orcid":false,"given":"Alex","family":"Guedes","sequence":"additional","affiliation":[{"name":"Grupo de Oncologia Ortop\u00e9dica, Hospital Santa Izabel, Santa Casa de Miseric\u00f3rdia da Bahia, Salvador, BA, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2629-9752","authenticated-orcid":false,"given":"Ricardo Gehrke","family":"Becker","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Trauma Ortop\u00e9dico, Hospital de Cl\u00ednicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1276-5679","authenticated-orcid":false,"given":"Luiz Eduardo Moreira","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Departamento do Aparelho Locomotor, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,6,29]]},"reference":[{"issue":"01","key":"ref1","first-page":"60","article-title":"Doen\u00e7a \u00f3ssea em mieloma m\u00faltiplo","volume":"29","author":"V TM Hungria","year":"2007","journal-title":"Rev Bras Hematol Hemoter"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1055\/a-0639-5742","article-title":"Multiple myeloma - Current standards in surgical treatment","volume":"157","author":"M Kehrer","year":"2019","journal-title":"Z Orthop Unfall"},{"issue":"02","key":"ref3","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1245\/s10434-020-08819-6","article-title":"Orthopedic surgical treatment and perioperative complications in multiple myeloma bone disease: Analysis of a series (2009-2018)","volume":"28","author":"M Gal\u00e1n-Olleros","year":"2021","journal-title":"Ann Surg Oncol"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4065\/78.1.21","article-title":"Review of 1027 patients with newly diagnosed multiple myeloma","volume":"78","author":"R A Kyle","year":"2003","journal-title":"Mayo Clin Proc"},{"issue":"05","key":"ref5","first-page":"162","article-title":"Avalia\u00e7\u00e3o do tratamento ortop\u00e9dico no mieloma m\u00faltiplo","volume":"37","author":"F M Ponte","year":"2002","journal-title":"Rev Bras Ortop"},{"issue":"04","key":"ref6","first-page":"e40","article-title":"Orthopaedic management of multiple myeloma lesions","volume":"6","author":"K S Katsekis","year":"2018","journal-title":"JBJS J Orthop Physician Assist"},{"issue":"08","key":"ref7","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1007\/s00264-010-1127-0","article-title":"Surgical therapy of skeletal complications in multiple myeloma","volume":"35","author":"S Utzschneider","year":"2011","journal-title":"Int Orthop"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1016\/S1470-2045(20)30559-3","article-title":"Treatment of multiple myeloma-related bone disease: recommendations from the Bone Working Group of the International Myeloma Working Group","volume":"22","author":"E Terpos","year":"2021","journal-title":"Lancet Oncol"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.hoc.2007.08.009","article-title":"Pathophysiology of multiple myeloma bone disease","volume":"21","author":"S Lentzsch","year":"2007","journal-title":"Hematol Oncol Clin North Am"},{"issue":"05","key":"ref10","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/ajh.25791","article-title":"Multiple myeloma: 2020 update on diagnosis, risk-stratification and management","volume":"95","author":"S V Rajkumar","year":"2020","journal-title":"Am J Hematol"},{"issue":"03","key":"ref12","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/os.12267","article-title":"Consensus on Surgical Management of Myeloma Bone Disease","volume":"8","author":"Surgeon's Committee of the Chinese Myeloma Working Group of the International Myeloma Foundation","year":"2016","journal-title":"Orthop Surg"},{"issue":"04","key":"ref13","first-page":"411","article-title":"Updating on Bone and Soft Tissue Sarcomas Staging","volume":"56","author":"A Guedes","year":"2021","journal-title":"Rev Bras Ortop"},{"issue":"02","key":"ref14","first-page":"179","article-title":"Update in Imaging Evaluation of Bone and Soft Tissue Sarcomas","volume":"58","author":"A Guedes","year":"2023","journal-title":"Rev Bras Ortop"},{"issue":"62","key":"ref15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.29327\/258045.23.62-6","article-title":"Abordagem ortop\u00e9dica das met\u00e1stases \u00f3sseas de carcinoma e mieloma m\u00faltiplo","volume":"23","author":"A Guedes","year":"2022","journal-title":"Rev SBC"},{"key":"ref16","first-page":"795","volume-title":"Mieloma m\u00faltiplo","author":"A Guedes","year":"2020"},{"issue":"09","key":"ref17","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1007\/s00066-017-1154-5","article-title":"Single vs. multiple fraction regimens for palliative radiotherapy treatment of multiple myeloma : A prospective randomised study","volume":"193","author":"M Rudzianskiene","year":"2017","journal-title":"Strahlenther Onkol"},{"issue":"03","key":"ref18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41408-019-0187-7","article-title":"The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: a consensus statement from the International Myeloma Working Group (IMWG)","volume":"9","author":"C Kyriakou","year":"2019","journal-title":"Blood Cancer J"},{"issue":"05","key":"ref19","doi-asserted-by":"crossref","first-page":"447","DOI":"10.36076\/ppj.2011\/14\/447","article-title":"The use of vertebral augmentation and external beam radiation therapy in the multimodal management of malignant vertebral compression fractures","volume":"14","author":"A E Hirsch","year":"2011","journal-title":"Pain Physician"},{"issue":"26","key":"ref20","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1200\/JCO.2015.61.2267","article-title":"Revised international staging system for multiple myeloma: A report from International Myeloma Working Group","volume":"33","author":"A Palumbo","year":"2015","journal-title":"J Clin Oncol"},{"issue":"S 03","key":"ref21","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1016\/S0020-1383(17)30659-9","article-title":"Carbon-fiber reinforced intramedullary nailing in musculoskeletal tumor surgery: a national multicentric experience of the Italian Orthopaedic Society (SIOT) Bone Metastasis Study Group","volume":"48","author":"A Piccioli","year":"2017","journal-title":"Injury"},{"issue":"03","key":"ref22","first-page":"e2020057","article-title":"The advantages of carbon fiber based orthopedic devices in patients who have to undergo radiotherapy","volume":"91","author":"A Soriani","year":"2020","journal-title":"Acta Biomed"},{"issue":"04","key":"ref23","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s00590-014-1555-4","article-title":"Reconstruction of multiple myeloma lesions around the pelvis and acetabulum","volume":"25","author":"V I Sakellariou","year":"2015","journal-title":"Eur J Orthop Surg Traumatol"},{"issue":"04","key":"ref24","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.3390\/curroncol28040238","article-title":"Emerging Concepts in the Surgical Management of Peri-Acetabular Metastatic Bone Disease","volume":"28","author":"A Gazendam","year":"2021","journal-title":"Curr Oncol"},{"key":"ref25","first-page":"3939356","article-title":"Total Hip Arthroplasty with a Cementless Acetabular Component and Impaction Bone Grafting for Dysplastic Osteoarthritis Complicated by Multiple Myeloma","volume":"2022","author":"R Ogawa","year":"2022","journal-title":"Case Rep Orthop"},{"issue":"05","key":"ref26","first-page":"1006","article-title":"The results of surgical management of bone metastasis involving the periacetabular area: Siriraj experience","volume":"90","author":"P Wangsaturaka","year":"2007","journal-title":"J Med Assoc Thai"},{"issue":"05","key":"ref27","doi-asserted-by":"crossref","first-page":"785","DOI":"10.14444\/7112","article-title":"Surgical Management of Multiple Myeloma With Symptomatic Involvement of the Spine","volume":"14","author":"H Milavec","year":"2020","journal-title":"Int J Spine Surg"},{"issue":"06","key":"ref28","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1634\/theoncologist.2012-0293","article-title":"The NOMS framework: approach to the treatment of spinal metastatic tumors","volume":"18","author":"I Laufer","year":"2013","journal-title":"Oncologist"},{"issue":"249","key":"ref29","first-page":"256","article-title":"Metastatic disease in long bones. A proposed scoring system for diagnosing impending pathologic fractures","author":"H Mirels","year":"1989","journal-title":"Clin Orthop Relat Res"},{"issue":"10","key":"ref30","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1007\/s11999-010-1326-4","article-title":"In brief: classifications in brief: Mirels' classification: metastatic disease in long bones and impending pathologic fracture","volume":"468","author":"M U Jawad","year":"2010","journal-title":"Clin Orthop Relat Res"},{"key":"ref31","first-page":"479","volume-title":"Metastatic Disease in Long Bones. A Proposed scoring system for diagnosing impending pathologic fractures","author":"C H Gerrand","year":"2014"},{"issue":"02","key":"ref32","doi-asserted-by":"crossref","first-page":"159","DOI":"10.5152\/j.aott.2021.20130","article-title":"Clinical outcomes and complications of surgical interventions for multiple myeloma lesions in the extremities and pelvis: A retrospective clinical study","volume":"55","author":"O M Topkar","year":"2021","journal-title":"Acta Orthop Traumatol Turc"}],"container-title":["Revista Brasileira de Ortopedia"],"original-title":[],"language":"pt","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1770150.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T23:23:39Z","timestamp":1722554619000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1770150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":31,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2023,6,29]]},"published-print":{"date-parts":[[2023,6]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1770150","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0102-3616","1982-4378"],"issn-type":[{"value":"0102-3616","type":"print"},{"value":"1982-4378","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6]]}}}