{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:14:32Z","timestamp":1787948072280,"version":"build-2784847793"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:00:00Z","timestamp":1688601600000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sleep Sci"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003This study aimed at evaluating the risk for obstructive sleep apnea (OSA) and its frequency in adults with Treacher Collins syndrome (TCS). The association of OSA with excessive daytime sleepiness (EDS), respiratory symptoms, and clinical variables was also assessed.<\/jats:p><jats:p>\n          Material and Methods\u2003The subjects were prospectively screened for OSA through the Berlin Questionnaire and type I polysomnography. The Epworth Sleepiness Scale and the Respiratory Symptoms Questionnaire were used for assessing OSA-related symptoms. Quality of life was assessed by means of the Short Form 36 Health Survey.<\/jats:p><jats:p>\n          Results\u2003The sample comprised 20 adults with TCS (55.0% female), aged 22.6\u2009\u00b1\u20095.8 years. Mean values of systemic blood pressure (113.0\u2009\u00b1\u200912.6\/68.0\u2009\u00b1\u20099.5mmHg), body mass index (22.9\u2009\u00b1\u20095.9kg\/m2), neck (34.1\u2009\u00b1\u20094.3cm), and waist circumference (80.4\u2009\u00b1\u200913.6cm) characterized the sample. A high risk for OSA was detected in 35% of the sample. Polysomnography results indicated an OSA frequency of 44.4%, with a median apnea-hypopnea index (AHI) value of 3.8 events\/hour (minimum\u2009=\u20090.2; maximum\u2009=\u200977.5). Snoring (75.0%), nasal obstruction (70.0%) and EDS (20.0%) were the reported OSA-related symptoms. Quality of life median scores were 72.3 points (minimum\u2009=\u200945.0; maximum\u2009=\u200991.1). Strong positive correlations between AHI versus waist circumference and AHI versus systolic blood pressure were found. Moderate positive correlations between AHI versus body mass index and AHI versus neck circumference were detected. Negative correlation between AHI versus vitality were also observed.<\/jats:p><jats:p>\n          Conclusion\u2003Adults with TCS are at high risk for OSA, which is associated with respiratory symptoms, altered anthropometric measurements, increased systolic pressure and impairment of quality of life.<\/jats:p>","DOI":"10.1055\/s-0043-1770802","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T22:38:13Z","timestamp":1688683093000},"page":"139-147","source":"Crossref","is-referenced-by-count":2,"title":["Obstructive Sleep Apnea in Adults with Treacher Collins Syndrome is Related with Altered Anthropometric Measurements, Increased Blood Pressure and Impaired Quality of Life"],"prefix":"10.1055","volume":"16","author":[{"given":"Leide","family":"Vilma Fid\u00e9lis-da Silva","sequence":"additional","affiliation":[{"name":"Sleep and Functional Imaging Units, Laboratory of Physiology, University of Sao Paulo, Hospital for Rehabilitation of Craniofacial Anomalies, Bauru, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Henrique Kiemle-Trindade","sequence":"additional","affiliation":[{"name":"Sleep and Functional Imaging Units, Laboratory of Physiology, University of Sao Paulo, Hospital for Rehabilitation of Craniofacial Anomalies, Bauru, SP, Brazil"},{"name":"Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Medicine, University of Sao Paulo, Bauru, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Noel Marzano-Rodrigues","sequence":"additional","affiliation":[{"name":"Sleep and Functional Imaging Units, Laboratory of Physiology, University of Sao Paulo, Hospital for Rehabilitation of Craniofacial Anomalies, Bauru, SP, Brazil"},{"name":"Department of Biological Sciences, Bauru School of Dentistry, University of Sao Paulo, Bauru, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La\u00eds","family":"Hollara Medeiros","sequence":"additional","affiliation":[{"name":"Sleep and Functional Imaging Units, Laboratory of Physiology, University of Sao Paulo, Hospital for Rehabilitation of Craniofacial Anomalies, Bauru, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano","family":"Tonello","sequence":"additional","affiliation":[{"name":"Hospitalar Department, University of Sao Paulo, Hospital for Rehabilitation of Craniofacial Anomalies, Bauru, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivy","family":"Kiemle Trindade-Suedam","sequence":"additional","affiliation":[{"name":"Sleep and Functional Imaging Units, Laboratory of Physiology, University of Sao Paulo, Hospital for Rehabilitation of Craniofacial Anomalies, Bauru, SP, Brazil"},{"name":"Department of Biological Sciences, Bauru School of Dentistry, University of Sao Paulo, Bauru, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,7,6]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/gim.2015.29","article-title":"Treacher Collins syndrome: a clinical and molecular study based on a large series of patients","volume":"18","author":"M Vincent","year":"2016","journal-title":"Genet Med"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1177\/1055665621998138","article-title":"Treacher Collins Syndrome in the United States: Examining Incidence and Inpatient Interventions","volume":"58","author":"L Reid","year":"2021","journal-title":"Cleft Palate Craniofac J"},{"issue":"09","key":"ref3","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.3390\/genes12091392","article-title":"Treacher Collins Syndrome: Genetics, Clinical Features and Management","volume":"12","author":"B A 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