{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:02:06Z","timestamp":1792512126501,"version":"4.5.0"},"reference-count":14,"publisher":"Scientific Scholar","issue":"02","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["South Asian J Cancer"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>Gastric cancer (GC) is often ignored at a young age, which frequently leads to tragic consequences. The worldwide incidence of GC is increasing at a young age. In view of the limited Indian publication, we sought to characterize clinicopathological parameters and risk factors in the adolescents and young adults (AYA) population. Retrospective data from six centers (which are part of the Network of Oncology Clinical Trials in India) from 2015 to 2020 were collected from patient (18\u201339 years of age) records. This study was approved by the institutional ethical committee of individual centers. All statistical analyses were performed using Microsoft Excel and SPSS (Version 20). Data interpretation along with the analysis of obtained results was carried out using the following tests: Qualitative data was expressed in terms of frequency\/percentage. One-hundred fifty-two AYA GC patients were enrolled. The 31 to 39 years age group was most affected in which 76.3% were females. The majority of patients were nonalcoholic (93.4%), nonsmokers (98.0%), and without a family history (98.0%). The most common (MC) presenting symptom was abdominal pain (67.1%). MC site was antrum (48%). Among esophagogastric junction cancers, the majority were type I and II Siewert classifications (77% [20\/26] patients in cardia), MC histology\u2014signet ring cell (67.1%) followed by diffuse-type (65.1%). Most were poorly differentiated (65.1%) and were diagnosed at an advanced stage (III &amp; IV= 54.6%). This is one of our country's first large multicenter studies on GC in the AYA population. There was a higher female prevalence, aggressive tumor behavior and the majority of patients were diagnosed at a more advanced stage. The majority were nonsmokers with a negative family history. Awareness among general people, researchers, clinicians, and policymakers must be improved to better the loss of life years in the younger population.<\/jats:p>","DOI":"10.1055\/s-0043-1771275","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T18:57:50Z","timestamp":1689965870000},"page":"142-145","source":"Crossref","is-referenced-by-count":1,"title":["Adolescent and Young Adults with Gastric Cancer (AYA-GC)\u2014The Dilemma of an Under-Represented Group: A Multi-Institutional Analysis from the Indian Subcontinent"],"prefix":"10.25259","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2190-1927","authenticated-orcid":false,"given":"Soumya Surath","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Institute of Medical Sciences and Sum Hospital, Siksha \u2018O\u2019 Anusandhan Deemed to be University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1497-6293","authenticated-orcid":false,"given":"Swati Sucharita","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Institute of Medical Sciences and Sum Hospital, Siksha \u2018O\u2019 Anusandhan Deemed to be University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8378-5672","authenticated-orcid":false,"given":"Antara","family":"Sanyal","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Institute of Medical Sciences and Sum Hospital, Siksha \u2018O\u2019 Anusandhan Deemed to be University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanth","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Kayal","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnakumar","family":"Rathnam","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Meenakshi Mission Medical College and Research Center, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0268-7937","authenticated-orcid":false,"given":"S. V.","family":"Saju","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Meenakshi Mission Medical College and Research Center, Madurai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunu","family":"Cyriac","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Amala Institute of Medical Sciences, Thrissur, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Unnikrishnan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Amala Institute of Medical Sciences, Thrissur, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7100-8999","authenticated-orcid":false,"given":"Amit","family":"Sehrawat","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, 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