{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:57:46Z","timestamp":1785412666234,"version":"3.56.0"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Neurol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dysphagia is a common symptom in many neurologic disorders. Patients with oropharyngeal dysphagia present with difficulties when they start to swallow, often with coughing and choking; whereas patients with esophageal dysphagia describe the feeling that swallowed food stops in the chest. Chronic neurologic diseases such stroke, Parkinson's disease, or dementia often have dysphagia as a symptom, particularly oropharyngeal dysphagia, and the term \u201cneurogenic dysphagia\u201d is often used. A disruption of the sophisticated, integrated sensorimotor swallowing system is usually the main reason behind dysphagia. Dysphagia can be associated with aspiration leading to aspiration pneumonia, and chronic dysphagia can lead to weight loss and malnutrition. Patients with dysphagia, when accurately and promptly diagnosed through medical history, physical examination, and diagnostic tests, often can be treated and experience improved quality of life. The pathophysiological mechanisms behind dysphagia, its diagnosis, and potential treatments are discussed in this manuscript.<\/jats:p>","DOI":"10.1055\/s-0043-1771458","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T22:56:22Z","timestamp":1692053782000},"page":"530-539","source":"Crossref","is-referenced-by-count":18,"title":["Dysphagia in Neurological Disorders"],"prefix":"10.1055","volume":"43","author":[{"given":"Maan","family":"El Halabi","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Temple University Hospital, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remy","family":"Arwani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Temple University Hospital, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry P.","family":"Parkman","sequence":"additional","affiliation":[{"name":"GI Motility 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Speyer","year":"2022","journal-title":"J Clin Med"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1055\/s-0035-1564721","article-title":"Effectiveness of chin-tuck maneuver to facilitate swallowing in neurologic dysphagia","volume":"20","author":"M Saconato","year":"2016","journal-title":"Int Arch Otorhinolaryngol"},{"issue":"01","key":"ref15","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrgastro.2015.199","article-title":"Oropharyngeal dysphagia: manifestations and diagnosis","volume":"13","author":"N Rommel","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"01","key":"ref16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00455-016-9779-6","article-title":"History of the use and impact of compensatory strategies in management of swallowing disorders","volume":"32","author":"C L 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