{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:03:02Z","timestamp":1780920182557,"version":"3.54.1"},"reference-count":112,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"name":"NIH","award":["RF1 AG059088"],"award-info":[{"award-number":["RF1 AG059088"]}]},{"name":"NIH","award":["R21 AG065914"],"award-info":[{"award-number":["R21 AG065914"]}]},{"DOI":"10.13039\/100006312","name":"BrightFocus","doi-asserted-by":"crossref","award":["A2019444S"],"award-info":[{"award-number":["A2019444S"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH NIEHS","award":["R01 ES030226"],"award-info":[{"award-number":["R01 ES030226"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Neurol"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increasing research links the gut microbiome to neurodegenerative disorders. The gut microbiome communicates with the central nervous system via the gut\u2013brain axis and affects behavioral and cognitive phenotypes. Dysbiosis (a dysfunctional microbiome) drives increased intestinal permeability and inflammation that can negatively affect the brain via the gut\u2013brain axis. Healthier metabolic and lipid profiles and cognitive phenotypes are observed in individuals with more distinct microbiomes. In this review, we discuss the role of the gut microbiome and gut\u2013brain axis in neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease and related animal models, in cancer and cancer treatments, and in metabolic syndrome. We also discuss strategies to improve the gut microbiome and ultimately brain function. Because healthier cognitive phenotypes are observed in individuals with more distinct microbiomes, increased efforts are warranted to develop therapeutic strategies for those at increased risk of developing neurological disorders and patients diagnosed with those disorders.<\/jats:p>","DOI":"10.1055\/s-0043-1771459","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T23:09:11Z","timestamp":1692745751000},"page":"634-644","source":"Crossref","is-referenced-by-count":11,"title":["Gastrointestinal Dysfunction in Neurological and Neurodegenerative Disorders"],"prefix":"10.1055","volume":"43","author":[{"given":"Jacob","family":"Raber","sequence":"additional","affiliation":[{"name":"Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon"},{"name":"Division of Neuroscience, Oregon National Primate Research Center, Portland, Oregon"},{"name":"Department of Neurology, Oregon Health & Science University, Portland, Oregon"},{"name":"Department of Psychiatry, Oregon Health & Science University, Portland, Oregon"},{"name":"Department of Radiation Medicine, Oregon Health & Science University, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Sharpton","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Oregon State University, Corvallis, Oregon"},{"name":"Department of Statistics, Oregon State University, Corvallis, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"issue":"1756","key":"ref1","doi-asserted-by":"crossref","first-page":"20170286","DOI":"10.1098\/rstb.2017.0286","article-title":"The gut microbiome as a driver of individual variation in cognition and functional behaviour","volume":"373","author":"G L Davidson","year":"2018","journal-title":"Philos Trans R Soc Lond B Biol 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