{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T14:46:09Z","timestamp":1773585969822,"version":"3.50.1"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"S 01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>\n            Objective\u2003This study aimed to analyze the association between acute kidney injury (AKI) and abnormalities on brain magnetic resonance imaging (MRI) or death in neonates treated with therapeutic hypothermia for hypoxic-ischemic encephalopathy (HIE).<\/jats:p><jats:p>\n            Study Design\u2003This is a retrospective case\u2013control analysis of 380 neonates born at \u226535 weeks' gestation treated with therapeutic hypothermia for HIE. Death or abnormal brain MRI using the basal ganglia watershed scoring system was compared between neonates with and without AKI.<\/jats:p><jats:p>\n            Results\u2003A total of 51 (13.4%) neonates had AKI. Infants with AKI had higher rates of the composite of death or abnormal brain MRI (74.5 vs. 38.3%; p\u2009&lt;\u20090.001). Rate of death (21.6 vs. 5.5%; p\u2009&lt;\u20090.001) and severe abnormalities on MRI or death (43.1 vs. 19.1%; p\u2009&lt;\u20090.001) were also higher in neonates with AKI.<\/jats:p><jats:p>\n            Conclusion\u2003AKI is strongly associated with abnormalities on brain MRI or death in neonates with HIE. Identification of AKI in this patient population may be helpful in guiding clinical management and predicting potential neurodevelopmental impairment.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0043-1771502","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T22:56:33Z","timestamp":1691189793000},"page":"e2489-e2494","source":"Crossref","is-referenced-by-count":5,"special_numbering":"S","title":["Acute Kidney Injury and Abnormalities on Brain Magnetic Resonance Imaging or Death in Infants with Hypoxic\u2013Ischemic Encephalopathy: A Case\u2013Control Study"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1796-663X","authenticated-orcid":false,"given":"Eliza","family":"DeSantis","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, Thomas Jefferson University Hospital\/Nemours, Philadelphia, 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