{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T08:04:01Z","timestamp":1787731441568,"version":"build-2784847793"},"reference-count":15,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"07","license":[{"start":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T00:00:00Z","timestamp":1692316800000},"content-version":"vor","delay-in-days":48,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003To analyze the outcomes of a cohort of patients with high-risk histologies of endometrial cancer (EC) treated at Instituto Nacional de C\u00e2ncer (National Cancer Institute, INCA, in Portuguese), in Brazil.<\/jats:p><jats:p>\n          Materials and Methods\u2003We reviewed the medical records of patients with high-risk histologies of EC in any stage registered at INCA between 2010 and 2016 to perform a clinical and demographic descriptive analysis and to evaluate the outcomes in terms of recurrence and survival.<\/jats:p><jats:p>\n          Results\u2003From 2010 to 2016, 2,145 EC patients were registered and treated at INCA, and 466 had high-grade histologies that met the inclusion criteria. The mean age of the patients was 65 years, 44.6% were Caucasian, and 90% had a performance status of 0 or 1. The most common histology was high-grade endometrioid (31.1%), followed by serous carcinoma (25.3%), mixed (20.0%), carcinosarcoma (13.5%), and clear cell carcinoma (9.4%). Considering the 2018 F\u00e9d\u00e9ration Internationale de Gyn\u00e9cologie et d'Obst\u00e9trique (International Federation of Gynecology and Obstetrics, FIGO, in French) staging system, 44.8%, 12.4%, 29.8%, and 12.9% of the patient were in stages I, II, III or IV respectively. Age (&gt; 60 years), more than 50% of myoinvasion, higher stage, poor performance status, serous and carcinosarcoma histologies, and adjuvant treatment were independent factors associated with recurrence-free survival (RFS) and overall survival (OS) in the multivariate analysis.<\/jats:p><jats:p>\n          Conclusion\u2003The current findings reinforced the international data showing poor outcomes of these tumors, especially for serous and carcinosarcomas and tumors with advanced stages, with shorter survival and high recurrence rates in distant sites, independently of the FIGO stage. Adjuvant therapy was associated with better survival.<\/jats:p>","DOI":"10.1055\/s-0043-1772177","type":"journal-article","created":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T22:35:35Z","timestamp":1692398135000},"page":"e401-e408","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Characteristics and Outcomes of a High-grade Endometrial Cancer Cohort Treated at Instituto Nacional de C\u00e2ncer, Brazil"],"prefix":"10.61622","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1080-1058","authenticated-orcid":false,"given":"Eduardo","family":"Paulino","sequence":"additional","affiliation":[{"name":"Instituto Nacional de C\u00e2ncer, Rio de Janeiro, RJ, Brazil"},{"name":"Oncologia D'or, Rio de Janeiro, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1201-4333","authenticated-orcid":false,"given":"Andreia Cristina de","family":"Melo","sequence":"additional","affiliation":[{"name":"Instituto 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