{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:57:16Z","timestamp":1791446236092,"version":"4.3.3"},"reference-count":34,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003Periodontal debridement involves conventional scaling and root planing (SRP) along with variant forms of adjunctive therapies. In the present clinical trial, we investigated if the adjunctive use of HybenX gel or diode laser along with SRP could provide a favorable outcome for the treatment of chronic periodontitis.<\/jats:p><jats:p>\n          Materials and Methods\u2003The present study involved 60 subjects diagnosed with chronic periodontitis who were randomly assigned as test groups (laser or HybenX) or control group (SRP alone). The primary outcomes of the clinical trial were pocket probing depth (PPD) and clinical attachment level (CAL), which was evaluated at baseline and at third-month time interval. Additionally, secondary outcomes included estimation of reduction in inflammatory mediators interleukin 1\u03b2 (IL-1\u03b2) and tumor necrosis factor \u03b1 (TNF-\u03b1) in gingival crevicular fluid using enzyme-linked immunosorbent assay at baseline and third-month intervals.<\/jats:p><jats:p>\n          Statistical Analysis\u2003Normality determination was checked using Shapiro\u2013Wilk test. Since the data was not normally distributed, nonparametric tests were applied. The comparison of clinical parameters between the groups was analyzed with Kruskal\u2013Wallis test. Wilcoxon sign rank test was used to compare the pairwise comparison of clinical parameters among the groups from baseline to third-month follow-up. The inflammatory mediators at various time points were compared using a One-way analysis of variance test, and the inflammatory mediators in each study group were compared using a paired t-test.<\/jats:p><jats:p>\n          Results\u2003Both the test groups demonstrated a decrease in PPD and CAL. However, the HybenX group exhibited statistically significant reduction at the end of the third-month study interval compared to the laser group and SRP alone. Further, the secondary outcome IL-1\u03b2 and TNF-\u03b1 analysis exhibited statistically significant reduction in all the groups posttherapy.<\/jats:p><jats:p>\n          Conclusion\u2003The adjunctive application of HybenX gel yielded an advantage compared to laser and SRP for the treatment of chronic periodontitis.<\/jats:p><jats:p>\n          Clinical Relevance\u2003Adjunctive use of the oral tissue desiccant (HybenX gel) combined with SRP improved the periodontal pocket disinfection process and enhanced tissue healing devoid of adverse effects.<\/jats:p>","DOI":"10.1055\/s-0043-1772567","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T23:07:00Z","timestamp":1697584020000},"page":"526-533","source":"Crossref","is-referenced-by-count":8,"title":["Anti-infective Efficacy of Mechanical Debridement with Adjunctive Modalities on Clinical and Cytokine Parameters in Treatment of Chronic Periodontitis: Randomized Controlled Clinical Trial"],"prefix":"10.1055","volume":"18","author":[{"given":"Anjale","family":"Rajagopal","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8503-5039","authenticated-orcid":false,"given":"Jothi","family":"Varghese","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinutha","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibha","family":"Acharya","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinayak","family":"Kamath","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Goa Dental College and Hospital, Bambolim, Goa, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.0303-6979.2004.00467.x","article-title":"Comparative clinical responses related to the use of various periodontal instrumentation","volume":"31","author":"P R Obeid","year":"2004","journal-title":"J Clin Periodontol"},{"issue":"S 03","key":"ref2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1034\/j.1600-051X.29.s3.4.x","article-title":"A systematic review of efficacy of machine-driven and manual subgingival debridement in the treatment of chronic periodontitis","volume":"29","author":"J Tunkel","year":"2002","journal-title":"J Clin Periodontol"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1600-0757.2012.00450.x","article-title":"Periodontitis: a host-mediated disruption of microbial homeostasis. 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