{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T22:54:47Z","timestamp":1776293687551,"version":"3.50.1"},"reference-count":26,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","issue":"11","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev Bras Ginecol Obstet"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective\u2003To determine the association between fetal macrosomia (FM) and postpartum hemorrhage (PPH) in Latin American and Caribbean (LAC) women.<\/jats:p><jats:p>\n          Data Sources\u2003Studies evaluating the association between FM and PPH (\u2265 500\u2009ml) and severe PPH (\u2265 1,000\u2009ml) until November 4, 2021, indexed in CINHAL, Scopus, Embase, Cochrane Library, MEDLINE, LILACS, and SciELO.<\/jats:p><jats:p>\n          Selection of Studies\u2003Inclusion criteria were cohort and case-control studies that provided the number of PPH and FM cases. Exclusion criteria were studies lacking information about the number of cases, with a population of women who were not from LAC; published in a language other than English, Spanish, or Portuguese, and with a different design.<\/jats:p><jats:p>\n          Data Collection\u2003Data extraction was performed independently by two authors, and discrepancies were resolved with a third author. Data regarding FM and PPH cases were retrieved.<\/jats:p><jats:p>\n          Data Synthesis\u2003Of the 1,044 articles evaluated, 5 studies were included, from 6 different countries: Argentina and Uruguay (multi-country), West Indies, Antigua and Barbuda, French Guyana, and Suriname. The pooled odds ratio (OR) for FM and PPH in the meta-analysis (five studies) was 2.10 (95% confidence interval [CI]: 1.79\u20132.47; I2: 0%), with estimates within this 95% CI in the sensitivity analysis. The combined OR for severe PPH (3 studies) was 1.61 (95% CI: 0.40\u20136.48; I2: 91.89%), showing high heterogeneity.<\/jats:p><jats:p>\n          Conclusion\u2003There was a positive association between FM and PPH in the LAC, increasing the risk of the presence of this event 2-fold. The high heterogeneity of the studies that measured severe PPH does not allow drawing conclusions about the estimates obtained.<\/jats:p>","DOI":"10.1055\/s-0043-1772597","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T23:48:05Z","timestamp":1701301685000},"page":"e706-e723","source":"Crossref","is-referenced-by-count":6,"title":["Fetal Macrosomia and Postpartum Hemorrhage in Latin American and Caribbean Region: Systematic Review and Meta-analysis"],"prefix":"10.61622","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9290-1540","authenticated-orcid":false,"given":"Araceli","family":"Quezada-Robles","sequence":"additional","affiliation":[{"name":"Universidad Cient\u00edfica del Sur, Facultad de Ciencias de la Salud, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4530-9792","authenticated-orcid":false,"given":"Fiorella","family":"Quispe-Sarmiento","sequence":"additional","affiliation":[{"name":"Universidad Cient\u00edfica del Sur, Facultad de Ciencias de la Salud, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5140-0843","authenticated-orcid":false,"given":"Guido","family":"Bendezu-Quispe","sequence":"additional","affiliation":[{"name":"Universidad C\u00e9sar Vallejo. Escuela de Medicina. Trujillo, Per\u00fa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3310-8689","authenticated-orcid":false,"given":"Rodrigo","family":"Vargas-Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Universidad Cient\u00edfica del Sur, Facultad de Ciencias de la Salud, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"47794","published-online":{"date-parts":[[2023,11,29]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002351","article-title":"Practice Bulletin No. 183: Postpartum Hemorrhage","volume":"130","year":"2017","journal-title":"Obstet Gynecol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1016\/S0140-6736(16)31470-2","article-title":"Global, regional, and national levels of maternal mortality, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"N J Kassebaum","year":"2016","journal-title":"Lancet"},{"issue":"07","key":"ref3","doi-asserted-by":"publisher","first-page":"e41114","DOI":"10.1371\/journal.pone.0041114","article-title":"Identifying regional variation in the prevalence of postpartum haemorrhage: a systematic review and meta-analysis","volume":"7","author":"C Calvert","year":"2012","journal-title":"PLoS One"},{"issue":"03","key":"ref4","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/uog.20278","article-title":"Maternal and neonatal complications of fetal macrosomia: cohort study","volume":"54","author":"J Beta","year":"2019","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"10","key":"ref5","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.3109\/14767058.2012.674990","article-title":"Increased composite maternal and neonatal morbidity associated with ultrasonographically suspected fetal macrosomia","volume":"25","author":"J R King","year":"2012","journal-title":"J Matern Fetal Neonatal Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/1471-2393-13-90","article-title":"Adverse maternal outcomes associated with fetal macrosomia: what are the risk factors beyond birthweight?","volume":"13","author":"F Fuchs","year":"2013","journal-title":"BMC Pregnancy Childbirth"},{"issue":"01","key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003606","article-title":"Macrosomia: ACOG Practice Bulletin, Number 216","volume":"135","year":"2020","journal-title":"Obstet Gynecol"},{"issue":"9865","key":"ref9","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/S0140-6736(12)61605-5","article-title":"Macrosomia in 23 developing countries: an analysis of a multicountry, facility-based, cross-sectional survey","volume":"381","author":"A Koyanagi","year":"2013","journal-title":"Lancet"},{"issue":"03","key":"ref10","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/S2213-8587(19)30026-9","article-title":"The obesity transition: stages of the global epidemic","volume":"7","author":"L M Jaacks","year":"2019","journal-title":"Lancet Diabetes Endocrinol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"M J Page","year":"2021","journal-title":"BMJ"},{"issue":"01","key":"ref13","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan-a web and mobile app for systematic reviews","volume":"5","author":"M Ouzzani","year":"2016","journal-title":"Syst Rev"},{"key":"ref15","volume-title":"Meta-Analysis in Stata: An Updated Collection from the Stata Journal Second Edition","author":"T M Palmer"},{"issue":"7414","key":"ref16","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"J PT Higgins","year":"2003","journal-title":"BMJ"},{"key":"ref18","volume-title":"Factores Asociados a La Aton\u00eda Uterina En Pu\u00e9rperas Del Hospital Uldarico Rocca Fern\u00e1ndez - 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