{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:53:39Z","timestamp":1740142419224,"version":"3.37.3"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Genetic variants play a pathophysiological role in headaches, especially in migraine. The Mennonite group (MG) has been geographically and genetically isolated throughout its history, harboring a distinctive distribution of diseases.<\/jats:p><jats:p>\n          Objective\u2003To determine the characteristics of headaches in a group with direct Mennonite ancestry contrasting with other urban community members (control group [CG]).<\/jats:p><jats:p>\n          Methods\u2003Subjects with headaches were asked to complete a questionnaire covering: the type of headache, presence of aura, frequency and duration of attacks, pain location and severity, analgesic consumption, premonitory and postdromic manifestations, Depressive Thoughts Scale, Epworth Sleepiness Scale (ESS), General Anxiety Disorder-7, Patient Health Questionnaire-9 (PHQ-9), Migraine Disability Assessment, and Composite Autonomic System Score.<\/jats:p><jats:p>\n          Results\u2003We included 103 participants (CG: 45, Mennonite group [MG]: 58). Migraine was the most common headache (CG: 91.1%; MG: 81.0%; p\u2009=\u20090.172), followed by tension-type headache (CG: 8.9%; MG: 15.5%; p\u2009=\u20090.381). Aura was identified by 44.4% and 39.7% in the CG and MG, respectively (p\u2009=\u20090.689). The groups differed only concerning the frequency of retro-orbital pain (CG: 55.6%; MG: 32.8%; p\u2009=\u20090.027), PHQ-9 (CG: median 7, range 0 to 22; MG: median 5, range 0 to 19; p\u2009=\u20090.031) and ESS (CG: median 0, range 0 to 270; MG: median 0, range 0 to 108; p\u2009=\u20090.048) scores.<\/jats:p><jats:p>\n          Conclusion\u2003There were no major differences in the prevalence and clinical characterization of headaches between the MG and the CG. However, the latter showed more diffuse pain, sleepiness, and depressive symptoms. Specific genetic or epigenetic variants in Mennonite descendants might account for these differences.<\/jats:p>","DOI":"10.1055\/s-0043-1772603","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T18:32:50Z","timestamp":1698172370000},"page":"795-802","source":"Crossref","is-referenced-by-count":1,"title":["Clinical characteristics of headaches in an urban Mennonite group in South Brazil"],"prefix":"10.1055","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1994-5288","authenticated-orcid":false,"given":"David Lemke","family":"D\u00fcck","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Setor de Ci\u00eancias da Sa\u00fade, Curitiba PR, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5273-6798","authenticated-orcid":false,"given":"Marco Antonio Takashi","family":"Utiumi","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Neurologia S\u00e3o Jos\u00e9, Centro de Cefaleia, S\u00e3o Jos\u00e9 dos Pinhais PR, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0902-9622","authenticated-orcid":false,"given":"Angelica Beate Winter","family":"Boldt","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Departamento de Gen\u00e9tica, Curitiba PR, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-0430","authenticated-orcid":false,"given":"Elcio Juliato","family":"Piovesan","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Neurologia S\u00e3o Jos\u00e9, Centro de Cefaleia, S\u00e3o Jos\u00e9 dos Pinhais PR, Brazil."},{"name":"Universidade Federal do Paran\u00e1, Departamento de Cl\u00ednica M\u00e9dica, Curitiba PR, 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