{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:52:10Z","timestamp":1760647930613,"version":"3.37.3"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T00:00:00Z","timestamp":1696377600000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq Neuropsiquiatr"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003The prevalence of pain in patients with multiple sclerosis is remarkable. Fibromyalgia has been considered as one of the forms of chronic pain encompassed in multiple sclerosis, but data are restricted to studies from Europe and North America.<\/jats:p><jats:p>\n          Objective\u2003To assess the prevalence of fibromyalgia in a series of Brazilian patients with multiple sclerosis and the characteristics of this comorbidity.<\/jats:p><jats:p>\n          Methods\u2003The present cross-sectional study included 60 consecutive adult patients with multiple sclerosis. Upon consent, participants underwent a thorough evaluation for disability, fatigue, quality of life, presence of fibromyalgia, depression, and anxiety.<\/jats:p><jats:p>\n          Results\u2003The prevalence of fibromyalgia was 11.7%, a figure similar to that observed in previous studies. Patients with the comorbidity exhibited worse scores on fatigue (median and interquartile range [IQR]: 68 [48\u201370] versus 39 [16.5\u201349]; p\u2009&lt;\u20090.001), quality of life (mean\u2009\u00b1\u2009standard deviation [SD]: 96.5\u2009\u00b1\u200935.9 versus 124.8\u2009\u00b1\u200928.8; p\u2009=\u20090.021), anxiety (mean\u2009\u00b1\u2009SD: 22.7\u2009\u00b1\u200915.1 versus 13.8\u2009\u00b1\u20098.4; p\u2009=\u20090.021), and depression (median and IQR: 23 [6\u201328] versus 6 [3\u201312.5]; p\u2009=\u20090.034) indices than patients without fibromyalgia. There was a strong positive correlation between depression and anxiety scores with fatigue (r\u2009=\u20090.773 and r\u2009=\u20090.773, respectively; p\u2009&lt;\u20090.001). Conversely, a moderate negative correlation appeared between the Expanded Disability Status Scale (EDSS), fatigue, and depression scores with quality of life (r= \u22120.587, r= \u22120.551, r= \u22120.502, respectively; p\u2009&lt;\u20090.001).<\/jats:p><jats:p>\n          Conclusion\u2003Fibromyalgia is a comorbidity of multiple sclerosis that can enhance fatigue and decrease quality of life, although depression, anxiety, and disability are factors that can potentiate the impact of the comorbidity.<\/jats:p>","DOI":"10.1055\/s-0043-1772673","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T18:32:50Z","timestamp":1698172370000},"page":"803-808","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence of fibromyalgia in a Brazilian series of patients with multiple sclerosis"],"prefix":"10.1055","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2223-4492","authenticated-orcid":false,"given":"Cinthia","family":"Thomas","sequence":"additional","affiliation":[{"name":"Hospital S\u00e3o Vicente de Paulo, Passo Fundo RS, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1910-2651","authenticated-orcid":false,"given":"Bianca Thais","family":"Schneider","sequence":"additional","affiliation":[{"name":"Universidade de Passo Fundo, Faculdade de Medicina, Passo Fundo RS, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2227-2085","authenticated-orcid":false,"given":"Caroline Schiochet","family":"Verza","sequence":"additional","affiliation":[{"name":"Universidade de Passo Fundo, Faculdade de Medicina, Passo Fundo RS, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2188-6069","authenticated-orcid":false,"given":"Gabriel","family":"Fassina","sequence":"additional","affiliation":[{"name":"Universidade de Passo Fundo, Faculdade de Medicina, Passo Fundo RS, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8373-2183","authenticated-orcid":false,"given":"La\u00eds Restel","family":"Weber","sequence":"additional","affiliation":[{"name":"Universidade de Passo Fundo, Faculdade de Medicina, Passo Fundo RS, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0018-2022","authenticated-orcid":false,"given":"Marlinton","family":"Moreira","sequence":"additional","affiliation":[{"name":"Universidade de Passo Fundo, Faculdade de Medicina, Passo Fundo RS, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1700-5863","authenticated-orcid":false,"given":"Paula Tormen","family":"Fusinato","sequence":"additional","affiliation":[{"name":"Universidade de Passo Fundo, Faculdade de Medicina, Passo Fundo RS, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9614-1139","authenticated-orcid":false,"given":"Cassiano Mateus","family":"Forcelini","sequence":"additional","affiliation":[{"name":"Hospital S\u00e3o Vicente de Paulo, Passo Fundo RS, Brazil."},{"name":"Universidade de Passo Fundo, Faculdade de Medicina, Passo Fundo RS, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2023,10,4]]},"reference":[{"issue":"14","key":"ref1","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition","volume":"26","author":"C Walton","year":"2020","journal-title":"Mult Scler"},{"issue":"07","key":"ref2","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s40273-021-01032-7","article-title":"Economic burden of multiple sclerosis in low- and middle-income countries: a systematic review","volume":"39","author":"J Dahham","year":"2021","journal-title":"PharmacoEconomics"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1177\/1352458514564491","article-title":"A systematic review of the incidence and prevalence of comorbidity in multiple sclerosis: overview","volume":"21","author":"R A Marrie","year":"2015","journal-title":"Mult Scler"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.pain.2012.12.002","article-title":"Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis","volume":"154","author":"P L Foley","year":"2013","journal-title":"Pain"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"758","DOI":"10.12659\/MSM.890009","article-title":"Chronic pain in multiple sclerosis: is there also fibromyalgia? 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