{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:05:17Z","timestamp":1793851517871,"version":"4.6.1"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p>\n            Background\u2003Few previous studies indicated the role of oxidative stress in the pathogenesis of childhood idiopathic thrombocytopenic purpura (ITP), but there are little data regarding changes in redox balance in different forms of the disease, and changes after therapeutic procedures. We aimed to investigate the values of pro-oxidants and antioxidative capacity in various forms of ITP before and after the applying therapy.<\/jats:p><jats:p>\n            Materials and Methods\u2003The research included 102 children, classified into the following groups: (1) newly diagnosed ITP (ndITP), (2) persistent ITP, (3) chronic ITP (chITP), and (4) control groups: (A) healthy control and (B) previously experienced ITP\u2014healthy children who had been suffering from ITP earlier. During the clinical assessment, a blood sample was taken from the patients, from which the value of pro-oxidants (index of lipid peroxidation measured as TBARS, nitrites [NO2\n            \u2212], as measurement of nitric oxide [NO] production, superoxide anion radical [O2\n            \u2212], and hydrogen peroxide [H2O2]) and the capacity of antioxidant protection (activity of superoxide dismutase and catalase, and quantity of reduced glutathione) were determined spectrophotometrically.<\/jats:p><jats:p>\n            Results\u2003Our results demonstrated that values of pro-oxidants, especially reflected through the TBARS and O2\n            \u2212, were the highest in the ndITP and exacerbated chITP groups. Also, the activity of the endogenous antioxidative defense system was the lowest in these groups. Intravenous immunoglobulin therapy in the ndITP group exerted the most prominent effect on the redox balance.<\/jats:p><jats:p>\n            Conclusion\u2003It can be concluded that severity and exacerbation of the ITP are closely related to the redox status.<\/jats:p>","DOI":"10.1055\/s-0043-1772683","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T23:01:58Z","timestamp":1692658918000},"page":"1129-1139","source":"Crossref","is-referenced-by-count":2,"title":["Variations of Redox Balance in Different Stages of Childhood Immune Thrombocytopenic Purpura"],"prefix":"10.1055","volume":"123","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2031-9102","authenticated-orcid":false,"given":"Rasa H.","family":"Medovic","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia"},{"name":"University Clinical Center Kragujevac, Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3835-1856","authenticated-orcid":false,"given":"Ivan M.","family":"Srejovic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia"},{"name":"Center of Excellence for the Study of Redox Balance in Cardiovascular and Metabolic Disorders, University of Kragujevac, Kragujevac, Serbia"},{"name":"Department of Pharmacology, First Moscow State Medical University I.M. Sechenov, Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1575-8714","authenticated-orcid":false,"given":"Marija V.","family":"Medovic","sequence":"additional","affiliation":[{"name":"University Clinical Center Kragujevac, Kragujevac, Serbia"},{"name":"Department of Dermatovenerology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9141-4281","authenticated-orcid":false,"given":"Isidora M.","family":"Milosavljevic","sequence":"additional","affiliation":[{"name":"Center of Excellence for the Study of Redox Balance in Cardiovascular and Metabolic Disorders, University of Kragujevac, Kragujevac, Serbia"},{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7829-5812","authenticated-orcid":false,"given":"Marina R.","family":"Nikolic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia"},{"name":"Center of Excellence for the Study of Redox Balance in Cardiovascular and Metabolic Disorders, University of Kragujevac, Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6429-7953","authenticated-orcid":false,"given":"Aleksandra Z.","family":"Stojanovic","sequence":"additional","affiliation":[{"name":"Center of Excellence for the Study of Redox Balance in Cardiovascular and Metabolic Disorders, University of Kragujevac, Kragujevac, Serbia"},{"name":"Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos B.","family":"Kuzmanovic","sequence":"additional","affiliation":[{"name":"Mother and Child Health Institute of Serbia \u201cDr Vukan Cupic\u201d, Belgrade, Serbia"},{"name":"Department of Pediatrics, Medical Faculty, University of Belgrade, Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1797-2725","authenticated-orcid":false,"given":"Predrag M.","family":"Djurdjevic","sequence":"additional","affiliation":[{"name":"University Clinical Center Kragujevac, Kragujevac, Serbia"},{"name":"Department of Internal medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1574-477X","authenticated-orcid":false,"given":"Sergey B.","family":"Bolevich","sequence":"additional","affiliation":[{"name":"Department of Human Pathology, First Moscow State Medical University I.M. Sechenov, Moscow, Russia Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9080-5763","authenticated-orcid":false,"given":"Vladimir P.","family":"Fisenko","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, First Moscow State Medical University I.M. Sechenov, Moscow, Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0071-8376","authenticated-orcid":false,"given":"Vladimir Lj.","family":"Jakovljevic","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia"},{"name":"Center of Excellence for the Study of Redox Balance in Cardiovascular and Metabolic Disorders, University of Kragujevac, Kragujevac, Serbia"},{"name":"Department of Human Pathology, First Moscow State Medical University I.M. 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