{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:59:53Z","timestamp":1768445993934,"version":"3.49.0"},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n            Objective\u2003Percent glycated albumin (%GAlb) is a marker of glycemia over the past 2 to 3 weeks in nonpregnant individuals. Longitudinal changes in %GAlb extending throughout pregnancy and postpartum (PP) have not been described. We aimed to describe levels of %GAlb throughout pregnancy and PP and relationships with glycemia.<\/jats:p><jats:p>\n            Study Design\u2003Fifty women among those in the Study of Pregnancy Regulation of INsulin and Glucose cohort underwent 75-g oral glucose tolerance tests (OGTTs) at a mean of 13 weeks (V1) and 26 weeks (V2) of gestation and 11 weeks' PP. %GAlb was measured on frozen plasma samples.<\/jats:p><jats:p>\n            Results\u2003Total albumin decreased from V1 to V2 and increased PP to levels higher than at V1. %GAlb declined between V1 and V2 (\u03b2\u2009=\u2009\u2212\u20090.63% 95% CI [\u22120.8, \u22120.6] p\u2009&lt;\u20090.001) and remained stable between V2 and PP (\u03b2\u2009=\u2009\u2212\u20090.04% [\u22120.3, 0.2] p\u2009=\u20090.78). Body mass index (BMI) was inversely related to %GAlb in pregnancy (V1: rho\u2009=\u2009\u2212\u20090.5, p\u2009=\u20090.0001; V2 rho\u2009=\u2009\u2212\u20090.4, p\u2009=\u20090.006), but not PP (rho\u2009=\u2009\u2212\u20090.15, p\u2009=\u20090.31). The longitudinal changes in %GAlb persisted after adjusting for BMI. Neither glycemia measurements nor hemoglobin A1c were associated with %GAlb at any time point, and adjustments for BMI did not reveal additional associations.<\/jats:p><jats:p>\n            Conclusion\u2003%GAlb decreases between early and late gestation and remains decreased PP, despite a PP increase in total albumin above early pregnancy values. Given the lack of correlation with OGTT values or A1c, %GAlb is unlikely to be useful in assessing glycemia in pregnant or PP women.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/s-0043-1772746","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T22:56:50Z","timestamp":1693263410000},"page":"115-121","source":"Crossref","is-referenced-by-count":3,"title":["Glycated Albumin and Glycemia in Pregnancy and Postpartum: A Pilot Study"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9066-9757","authenticated-orcid":false,"given":"Marti D.","family":"Soffer","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, Massachusetts"},{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlyn E.","family":"James","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, Massachusetts"},{"name":"Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts"},{"name":"Deborah Kelly Center for Outcomes Research, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanayott","family":"Thaweethai","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, Massachusetts"},{"name":"Department of Biostatistics, Biostatistics, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Callahan","sequence":"additional","affiliation":[{"name":"Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"William H.","family":"Barth","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, Massachusetts"},{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille E.","family":"Powe","sequence":"additional","affiliation":[{"name":"Harvard Medical School, Boston, Massachusetts"},{"name":"Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts"},{"name":"Department of Biostatistics, Biostatistics, Massachusetts General Hospital, Boston, Massachusetts"},{"name":"Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts"},{"name":"Broad Institute, Cambridge, 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