{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:08:08Z","timestamp":1788898088723,"version":"build-2803163510"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background\u2003Balloon pulmonary angioplasty (BPA) is a promising interventional treatment for inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Evidence in favor of BPA is growing, but long-term data remain scarce. The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) is validated for the assessment of patients with pulmonary hypertension within three domains: symptoms, activity, and quality of life (QoL). The aim of the present study was to evaluate the long-term effects of BPA on these domains in patients with inoperable CTEPH.<\/jats:p><jats:p>\n          Methods\u2003Between March 2014 and August 2019, technically inoperable patients with target lesions for BPA were included in this prospective, observational study. CAMPHOR scores were compared between baseline (before the first BPA) and 6 months after the last intervention and also for scores assessed at annual follow-ups.<\/jats:p><jats:p>\n          Results\u2003A total of 152 patients had completed a full series of BPA interventions and a 28 (interquartile range [IQR]: 26\u201332) week follow-up. Further follow-up assessments including the CAMPHOR score were performed 96 (IQR: 70\u2013117) weeks, 178 (IQR: 156\u2013200) weeks, and 250 (IQR: 237\u2013275) weeks after the last intervention. From baseline to the last follow-up, CAMPHOR scores for symptoms, activity, and QoL improved from 9 (IQR: 6\u201314) to 3 (IQR: 0\u20139) (p\u2009&lt;\u20090.001), 8 (IQR: 5\u201312) to 4 (IQR: 2\u20138) (p\u2009&lt;\u20090.001), and 5 (IQR: 2\u20139) to 1 (IQR: 0\u20135) (p\u2009&lt;\u20090.001).<\/jats:p><jats:p>\n          Conclusion\u2003BPA leads to long-lasting, significant improvement of symptoms, physical capacity, and QoL in inoperable CTEPH patients.<\/jats:p>","DOI":"10.1055\/s-0043-1772770","type":"journal-article","created":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T23:28:26Z","timestamp":1693351706000},"page":"237-243","source":"Crossref","is-referenced-by-count":6,"title":["Patient-Reported Long-Term Outcome of Balloon Pulmonary Angioplasty for Inoperable CTEPH"],"prefix":"10.1055","volume":"73","author":[{"given":"Christoph B.","family":"Wiedenroth","sequence":"additional","affiliation":[{"name":"Kerckhoff Heart and Thorax Center, Department of Thoracic Surgery, Bad Nauheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Steinhaus","sequence":"additional","affiliation":[{"name":"University of G\u00f6ttingen, Department of Cardiology and Pneumology, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Rolf","sequence":"additional","affiliation":[{"name":"Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Breithecker","sequence":"additional","affiliation":[{"name":"Kerckhoff Heart and Thorax Center, Department of Radiology, Bad Nauheim, Germany"},{"name":"Gesundheitszentrum Wetterau, Department of Radiology, Bad Nauheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam S. D.","family":"Adameit","sequence":"additional","affiliation":[{"name":"Kerckhoff Heart and Thorax Center, Department of Thoracic Surgery, Bad Nauheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen D.","family":"Kriechbaum","sequence":"additional","affiliation":[{"name":"Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site RheinMain, Bad Nauheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Haas","sequence":"additional","affiliation":[{"name":"Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fritz","family":"Roller","sequence":"additional","affiliation":[{"name":"University of Giessen, Department of Radiology, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian W.","family":"Hamm","sequence":"additional","affiliation":[{"name":"Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site RheinMain, Bad Nauheim, Germany"},{"name":"University of Giessen, Department of Internal Medicine I, Division of Cardiology, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.-Ardeschir","family":"Ghofrani","sequence":"additional","affiliation":[{"name":"Kerckhoff Heart and Thorax Center, Department of Pulmonology, Bad Nauheim, Germany"},{"name":"Universities of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL)"},{"name":"Department of Medicine, Imperial College London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckhard","family":"Mayer","sequence":"additional","affiliation":[{"name":"Kerckhoff Heart and Thorax Center, Department of Thoracic Surgery, Bad Nauheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2238-9574","authenticated-orcid":false,"given":"Stefan","family":"Guth","sequence":"additional","affiliation":[{"name":"Kerckhoff Heart and Thorax Center, Department of Thoracic Surgery, Bad Nauheim, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Liebetrau","sequence":"additional","affiliation":[{"name":"Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), partner site RheinMain, Bad Nauheim, Germany"},{"name":"Cardioangiologisches Centrum Bethanien, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,8,29]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"1801915","DOI":"10.1183\/13993003.01915-2018","article-title":"Chronic thromboembolic pulmonary hypertension","volume":"53","author":"N H Kim","year":"2019","journal-title":"Eur Respir J"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"2002828","DOI":"10.1183\/13993003.02828-2020","article-title":"ERS statement on chronic thromboembolic pulmonary hypertension","volume":"57","author":"M Delcroix","year":"2021","journal-title":"Eur Respir J"},{"issue":"38","key":"ref3","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"43","author":"M Humbert","year":"2022","journal-title":"Eur Heart J"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.healun.2021.07.020","article-title":"Evaluation and management of patients with chronic thromboembolic pulmonary hypertension - consensus statement from the ISHLT","volume":"40","author":"M de Perrot","year":"2021","journal-title":"J Heart Lung Transplant"},{"issue":"18","key":"ref5","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1161\/CIRCULATIONAHA.110.015008","article-title":"Chronic thromboembolic pulmonary hypertension (CTEPH): results from an international prospective registry","volume":"124","author":"J Pepke-Zaba","year":"2011","journal-title":"Circulation"},{"issue":"03","key":"ref6","doi-asserted-by":"crossref","first-page":"00850","DOI":"10.1183\/23120541.00850-2020","article-title":"Current strategies for managing chronic thromboembolic pulmonary hypertension: results of the worldwide prospective CTEPH Registry","volume":"7","author":"S Guth","year":"2021","journal-title":"ERJ Open Res"},{"issue":"09","key":"ref7","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1161\/CIRCULATIONAHA.115.016522","article-title":"Long-term outcome of patients with chronic thromboembolic pulmonary hypertension: results from an international prospective registry","volume":"133","author":"M Delcroix","year":"2016","journal-title":"Circulation"},{"issue":"06","key":"ref8","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1161\/CIRCINTERVENTIONS.112.971077","article-title":"Refined balloon pulmonary angioplasty for inoperable patients with chronic thromboembolic pulmonary hypertension","volume":"5","author":"H Mizoguchi","year":"2012","journal-title":"Circ Cardiovasc Interv"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1161\/CIRCINTERVENTIONS.112.971390","article-title":"Percutaneous transluminal pulmonary angioplasty for the treatment of chronic thromboembolic pulmonary hypertension","volume":"5","author":"M Kataoka","year":"2012","journal-title":"Circ Cardiovasc Interv"},{"issue":"02","key":"ref10","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1253\/circj.CJ-11-1217","article-title":"Percutaneous transluminal pulmonary angioplasty markedly improves pulmonary hemodynamics and long-term prognosis in patients with chronic thromboembolic pulmonary hypertension","volume":"76","author":"K Sugimura","year":"2012","journal-title":"Circ J"},{"issue":"06","key":"ref11","doi-asserted-by":"crossref","first-page":"1602409","DOI":"10.1183\/13993003.02409-2016","article-title":"Balloon pulmonary angioplasty for inoperable patients with chronic thromboembolic pulmonary hypertension: the initial German experience","volume":"49","author":"K M Olsson","year":"2017","journal-title":"Eur Respir J"},{"issue":"05","key":"ref12","doi-asserted-by":"crossref","first-page":"1802095","DOI":"10.1183\/13993003.02095-2018","article-title":"French experience of balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension","volume":"53","author":"P Brenot","year":"2019","journal-title":"Eur Respir J"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"e001144","DOI":"10.1136\/openhrt-2019-001144","article-title":"Balloon pulmonary angioplasty for inoperable chronic thromboembolic pulmonary hypertension: the UK experience","volume":"7","author":"S P Hoole","year":"2020","journal-title":"Open Heart"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/20458940211007385","article-title":"Advances in balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension","volume":"11","author":"E Mahmud","year":"2021","journal-title":"Pulm Circ"},{"issue":"03","key":"ref15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/2045894018783996","article-title":"Sequential treatment with riociguat and balloon pulmonary angioplasty for patients with inoperable chronic thromboembolic pulmonary hypertension","volume":"8","author":"C B Wiedenroth","year":"2018","journal-title":"Pulm Circ"},{"issue":"04","key":"ref16","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1056\/NEJMoa1209657","article-title":"Riociguat for the treatment of chronic thromboembolic pulmonary hypertension","volume":"369","author":"H A Ghofrani","year":"2013","journal-title":"N Engl J Med"},{"issue":"24","key":"ref17","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1161\/CIRCULATIONAHA.116.024201","article-title":"Long-term outcomes after percutaneous transluminal pulmonary angioplasty for chronic thromboembolic pulmonary hypertension","volume":"134","author":"T Inami","year":"2016","journal-title":"Circulation"},{"issue":"42","key":"ref18","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1093\/eurheartj\/ehx530","article-title":"Comprehensive evaluation of the effectiveness and safety of balloon pulmonary angioplasty for inoperable chronic thrombo-embolic pulmonary hypertension: long-term effects and procedure-related complications","volume":"38","author":"T Aoki","year":"2017","journal-title":"Eur Heart J"},{"issue":"10","key":"ref19","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S2213-2600(22)00214-4","article-title":"Balloon pulmonary angioplasty versus riociguat for the treatment of inoperable chronic thromboembolic pulmonary hypertension (RACE): a multicentre, phase 3, open-label, randomised controlled trial and ancillary follow-up study","volume":"10","author":"X Ja\u00efs","year":"2022","journal-title":"Lancet Respir Med"},{"issue":"05","key":"ref20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/MCP.0000000000000188","article-title":"Balloon pulmonary angioplasty for inoperable chronic thromboembolic pulmonary hypertension","volume":"21","author":"T Ogo","year":"2015","journal-title":"Curr Opin Pulm Med"},{"issue":"01","key":"ref21","doi-asserted-by":"crossref","first-page":"1801919","DOI":"10.1183\/13993003.01919-2018","article-title":"The importance of patient perspectives in pulmonary hypertension","volume":"53","author":"M D McGoon","year":"2019","journal-title":"Eur Respir J"},{"issue":"01","key":"ref22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11136-005-3513-4","article-title":"The Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR): a measure of health-related quality of life and quality of life for patients with pulmonary hypertension","volume":"15","author":"S P McKenna","year":"2006","journal-title":"Qual Life Res"},{"issue":"02","key":"ref23","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1378\/chest.12-2443","article-title":"Patient-reported outcomes assessed by the CAMPHOR questionnaire predict clinical deterioration in idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension","volume":"144","author":"C McCabe","year":"2013","journal-title":"Chest"},{"issue":"04","key":"ref24","doi-asserted-by":"crossref","first-page":"1902096","DOI":"10.1183\/13993003.02096-2019","article-title":"CAMPHOR score: patient-reported outcomes are improved by pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension","volume":"56","author":"M Newnham","year":"2020","journal-title":"Eur Respir J"},{"issue":"05","key":"ref25","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.healun.2017.12.006","article-title":"N-terminal pro-B-type natriuretic peptide for monitoring after balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension","volume":"37","author":"S D Kriechbaum","year":"2018","journal-title":"J Heart Lung Transplant"},{"issue":"09","key":"ref26","doi-asserted-by":"crossref","first-page":"e0204683","DOI":"10.1371\/journal.pone.0204683","article-title":"Dynamics of high-sensitivity cardiac troponin T during therapy with balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension","volume":"13","author":"S D Kriechbaum","year":"2018","journal-title":"PLoS One"},{"issue":"03","key":"ref27","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1007\/s00330-018-5702-x","article-title":"Correlation of native T1 mapping with right ventricular function and pulmonary haemodynamics in patients with chronic thromboembolic pulmonary hypertension before and after balloon pulmonary angioplasty","volume":"29","author":"F C Roller","year":"2019","journal-title":"Eur Radiol"},{"issue":"04","key":"ref28","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1080\/00365513.2019.1601765","article-title":"Development of renal function during staged balloon pulmonary angioplasty for inoperable chronic thromboembolic pulmonary hypertension","volume":"79","author":"S D Kriechbaum","year":"2019","journal-title":"Scand J Clin Lab Invest"},{"issue":"07","key":"ref29","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1080\/1354750X.2020.1821776","article-title":"Galectin-3, GDF-15, and sST2 for the assessment of disease severity and therapy response in patients suffering from inoperable chronic thromboembolic pulmonary hypertension","volume":"25","author":"S D Kriechbaum","year":"2020","journal-title":"Biomarkers"},{"issue":"03","key":"ref30","first-page":"20","article-title":"Exercise right heart catheterization before and after balloon pulmonary angioplasty in inoperable patients with chronic thromboembolic pulmonary hypertension","volume":"10","author":"C B Wiedenroth Md","year":"2020","journal-title":"Pulm Circ"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"110111","DOI":"10.1016\/j.ejrad.2021.110111","article-title":"Effects of BPA on right ventricular mechanical dysfunction in patients with inoperable CTEPH - a cardiac magnetic resonance study","volume":"147","author":"F C Roller","year":"2022","journal-title":"Eur J Radiol"},{"issue":"06","key":"ref32","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1378\/chest.94.6.1249","article-title":"Balloon angioplasty in the treatment of pulmonary hypertension caused by pulmonary embolism","volume":"94","author":"J A Voorburg","year":"1988","journal-title":"Chest"},{"issue":"01","key":"ref33","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1161\/01.CIR.103.1.10","article-title":"Balloon pulmonary angioplasty for treatment of chronic thromboembolic pulmonary hypertension","volume":"103","author":"J A Feinstein","year":"2001","journal-title":"Circulation"},{"issue":"05","key":"ref34","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1055\/s-2003-39206","article-title":"Pulmonary balloon angioplasty of chronic thromboembolic pulmonary hypertension (CTEPH) in surgically inaccessible cases","volume":"175","author":"M B Pitton","year":"2003","journal-title":"R\u00f6fo Fortschr Geb R\u00f6ntgenstr Neuen Bildgeb Verfahr"},{"issue":"02","key":"ref35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jjcc.2020.02.015","article-title":"Balloon pulmonary angioplasty improves quality of life in Japanese patients with chronic thromboembolic pulmonary hypertension","volume":"76","author":"S Minatsuki","year":"2020","journal-title":"J Cardiol"},{"issue":"04","key":"ref36","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1253\/circj.CJ-16-1075","article-title":"Improvement in quality of life and hemodynamics in chronic thromboembolic pulmonary hypertension treated with balloon pulmonary angioplasty","volume":"81","author":"S Darocha","year":"2017","journal-title":"Circ J"},{"issue":"05","key":"ref37","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1253\/circrep.CR-19-0016","article-title":"Pulmonary endarterectomy and balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension - similar effects on health-related quality of life","volume":"1","author":"N Tamada","year":"2019","journal-title":"Circ Rep"},{"issue":"11","key":"ref38","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.3390\/jcm9113608","article-title":"Balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension: impact on clinical and hemodynamic parameters, quality of life and risk profile","volume":"9","author":"P Jansa","year":"2020","journal-title":"J Clin Med"},{"issue":"07","key":"ref39","doi-asserted-by":"crossref","first-page":"e0255180","DOI":"10.1371\/journal.pone.0255180","article-title":"Exercise tolerance and quality of life in hemodynamically partially improved patients with chronic thromboembolic pulmonary hypertension treated with balloon pulmonary angioplasty","volume":"16","author":"K Miura","year":"2021","journal-title":"PLoS One"}],"container-title":["The Thoracic and Cardiovascular Surgeon"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/s-0043-1772770.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T23:48:33Z","timestamp":1743551313000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/s-0043-1772770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,29]]},"references-count":39,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2025,4,1]]},"published-print":{"date-parts":[[2025,4]]}},"URL":"https:\/\/doi.org\/10.1055\/s-0043-1772770","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0171-6425","1439-1902"],"issn-type":[{"value":"0171-6425","type":"print"},{"value":"1439-1902","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,29]]}}}