{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T16:39:17Z","timestamp":1785515957888,"version":"3.56.0"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Semin Liver Dis"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:p>This review is to evaluate how much alcohol is safe in the context of alcohol-related liver disease (ALD). In patients without an established diagnosis of ALD consuming alcohol at quantities below 12 to 20\u2009g daily with alcohol-free days is associated with a very low risk of developing disease. This risk is mediated by the presence of cofactors such as sex, medical comorbidity, obesity, and genetic factors. A threshold effect below which liver disease will not occur is not seen, instead a dose\u2013response relationship where risk ranges from low to high. Once ALD is present, natural history studies confirm that continued alcohol consumption is clearly associated with an increased risk of ill health and premature death. In conclusion, low-level alcohol consumption in the absence of liver disease is associated with a very small risk of developing ALD, but once ALD is present patients should be supported to achieve complete abstinence from alcohol.<\/jats:p>","DOI":"10.1055\/s-0043-1772836","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T19:02:20Z","timestamp":1693249340000},"page":"305-310","source":"Crossref","is-referenced-by-count":5,"title":["Alcohol-Related Liver Disease: Is There a Safe Alcohol Consumption Limit for Liver Disease?"],"prefix":"10.1055","volume":"43","author":[{"given":"Katrina","family":"Pekarska","sequence":"additional","affiliation":[{"name":"Leeds Liver Unit, St James's University Hospital, Leeds, West Yorkshire, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Parker","sequence":"additional","affiliation":[{"name":"Leeds Liver Unit, St James's University Hospital, Leeds, West Yorkshire, 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