{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:52:37Z","timestamp":1792785157197,"version":"4.5.0"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"S 01","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Infant Bacterial Therapeutics Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>Objective\u2003Investigate daily feeding volumes and their association with clinical variables in the early postnatal care of premature infants of the \u201cConnection Trial.\u201d<\/jats:p>\n                  <jats:p>Study Design\u2003A total of 641 infants of 510 to 1,000-g birth weight (BW, mean: 847\u2009g) and mean 27 weeks' gestational age at birth (GA) were analyzed for total daily enteral (TDE) feeding volumes of 10, 20, 40, 80, and 120\u2009mL\/kg\/d and their association with 24 clinical variables. Uni- and multivariable Cox regression models were used to calculate hazard ratios (HR) with 95% confidence intervals as a measure of the chance of reaching each of the TDE volumes.<\/jats:p>\n                  <jats:p>Results\u2003Daily feeding volumes were highly variable and the median advancement from 10 to 120\u2009mL\/kg\/d was 11\u2009mL\/kg\/d. Univariable analyses showed the lowest chance (HR, 0.22\u20130.81) of reaching the TDE volumes for gastrointestinal (GI) serious adverse events (SAEs), GI perforation, GI obstruction, and necrotizing enterocolitis, as well as respiratory SAEs, persistent ductus arteriosus, and hypotension. Each GA week, 100-g BW, and point in 5-minute Apgar score at birth associated with 8 to 20% increased chance of reaching the TDE volumes. Multivariable analyses showed independent effects for BW, GA, Apgar score, GI SAEs, abdominal symptoms\/signs, respiratory SAEs, days on antibiotics, and hypotension.<\/jats:p>\n                  <jats:p>Conclusion\u2003This observational analysis demonstrates the variable and cautious progression of enteral feedings in contemporary extremely low BW infants and the extent to which clinical variables associate with this progression.<\/jats:p>\n                  <jats:p>Key Points<\/jats:p>","DOI":"10.1055\/s-0043-1774314","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T18:44:06Z","timestamp":1694198646000},"page":"e2717-e2726","source":"Crossref","is-referenced-by-count":7,"special_numbering":"S","title":["Progression of Enteral Feeding Volumes in Extremely Low Birth Weight Infants in the \u201cConnection Trial\u201d"],"prefix":"10.1055","volume":"41","author":[{"given":"Josef","family":"Neu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Florida Health Shands Children's Hospital, Gainesville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Ashley","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Chowdhary","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Arkansas Children's Hospital, Little Rock, Arkansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Lampland","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Children's Minnesota St. Paul Clinic, Saint Paul, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Porcelli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Atrium Health Wake Forest Baptist Medical Center, Winston-Salem, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Rothstein","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Baystate Children's Hospital, Springfield, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boriana","family":"Slancheva","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Medical University of Sofia, Sofia, Bulgaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Kronstr\u00f6m","sequence":"additional","affiliation":[{"name":"Infant Bacterial Therapeutics Inc., Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Rastad","sequence":"additional","affiliation":[{"name":"Infant Bacterial Therapeutics Inc., Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staffan","family":"Str\u00f6mberg","sequence":"additional","affiliation":[{"name":"Infant Bacterial Therapeutics Inc., Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Thuresson","sequence":"additional","affiliation":[{"name":"Infant Bacterial Therapeutics Inc., Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Connection Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"e0232659","DOI":"10.1371\/journal.pone.0232659","article-title":"Impact 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